CatsWannaBeCats.Com | Wilder Rasch | Activity https://www.catswannabecats.com/members/powderyellow9/activity/ Activity feed for Wilder Rasch. Sun, 14 Jun 2026 00:41:31 -0400 https://buddypress.org/?v=7.2.0 en-CA 30 hourly 2 5500d631f246dbef6dfd05afa9b67c6b Wilder Rasch posted an update: Parkinson's disease (PD) is associated with proteostasis […] https://www.catswannabecats.com/activity/p/26525/ Tue, 10 Jun 2025 13:25:19 -0400 Parkinson’s disease (PD) is associated with proteostasis disturbances and accumulation of misfolded α-synuclein (α-syn), a cytosolic protein present in high concentrations at pre-synaptic neuronal terminals. It is a primary constituent of intracellular protein aggregates known as Lewy neurites or Lewy bodies. Progression of Lewy pathology caused b…[Read more]

]]> 0 7b8fbabd1f95d60ebfe6f1d42bad9b01 Wilder Rasch posted an update: Parkinson's disease (PD) is associated with proteostasis […] https://www.catswannabecats.com/activity/p/26501/ Tue, 10 Jun 2025 13:10:08 -0400 Parkinson’s disease (PD) is associated with proteostasis disturbances and accumulation of misfolded α-synuclein (α-syn), a cytosolic protein present in high concentrations at pre-synaptic neuronal terminals. It is a primary constituent of intracellular protein aggregates known as Lewy neurites or Lewy bodies. Progression of Lewy pathology caused b…[Read more]

]]> 0 d64c6b00db698e6fe89ea335a64d0357 Wilder Rasch posted an update: ty of plaques and abnormal lipid accumulation in ApoE-/- […] https://www.catswannabecats.com/activity/p/26202/ Mon, 09 Jun 2025 14:02:06 -0400 ty of plaques and abnormal lipid accumulation in ApoE-/- mice. Furthermore, these effects might be mediated through the p38 MAPK pathway.

In the absence of definitive diagnosis, healthcare providers are likely to prescribe empirical antibacterials to those who test negative for malaria. This problem is of critical importance in Southern Asia…[Read more]

]]> 0 6ac2b26357413dc68e6f6011ea89bb55 Wilder Rasch posted an update: Introduction Chemical burns are comparably rare but often […] https://www.catswannabecats.com/activity/p/24899/ Sun, 08 Jun 2025 13:57:35 -0400 Introduction Chemical burns are comparably rare but often result in full-thickness skin defects with frequent involvement of underlying structures. Hands are the most commonly affected injury site and impaired functional outcome is common. We present a case of an unusual chemical burn to the dorsum of the hand of a child secondary to application…[Read more]

]]> 0 54608d0ce5276387d4dbea8bda921308 Wilder Rasch posted an update: Illumina BeadChips are widely utilized in epigenome-wide […] https://www.catswannabecats.com/activity/p/22890/ Sat, 07 Jun 2025 13:55:26 -0400 Illumina BeadChips are widely utilized in epigenome-wide association studies (EWAS). Several studies have reported that many probes on these arrays have poor reliability. Here, we compare different pre-processing methods to improve intra-class correlation coefficients (ICC). We describe the characteristics of ICC across the genome, within and…[Read more]

]]> 0 28988edbe4cf7fae6f5e3fc41d4a564f Wilder Rasch posted an update: Illumina BeadChips are widely utilized in epigenome-wide […] https://www.catswannabecats.com/activity/p/22821/ Sat, 07 Jun 2025 13:46:51 -0400 Illumina BeadChips are widely utilized in epigenome-wide association studies (EWAS). Several studies have reported that many probes on these arrays have poor reliability. Here, we compare different pre-processing methods to improve intra-class correlation coefficients (ICC). We describe the characteristics of ICC across the genome, within and…[Read more]

]]> 0 87506e693039bbdf40cd93e4cb1abc82 Wilder Rasch posted an update: Illumina BeadChips are widely utilized in epigenome-wide […] https://www.catswannabecats.com/activity/p/22721/ Sat, 07 Jun 2025 13:30:12 -0400 Illumina BeadChips are widely utilized in epigenome-wide association studies (EWAS). Several studies have reported that many probes on these arrays have poor reliability. Here, we compare different pre-processing methods to improve intra-class correlation coefficients (ICC). We describe the characteristics of ICC across the genome, within and…[Read more]

]]> 0 cb008ca9a7920d2a0dad371fb97e0985 Wilder Rasch posted an update: Unfolding and refolding of multidomain proteins under force […] https://www.catswannabecats.com/activity/p/21575/ Fri, 06 Jun 2025 14:08:56 -0400 Unfolding and refolding of multidomain proteins under force have yet to be recognized as a major mechanism of function for proteins in vivo. In this review, we discuss the inherent properties of multidomain proteins under a force vector from a structural and functional perspective. We then characterize three main systems where multidomain proteins…[Read more]

]]> 0 178dfff52b5fb06662b22e59df00d4e8 Wilder Rasch posted an update: Foci of inflammasome activation were co-localised with these […] https://www.catswannabecats.com/activity/p/20503/ Thu, 05 Jun 2025 13:51:43 -0400 Foci of inflammasome activation were co-localised with these immune cell infiltrate, with significantly increased staining for adaptor protein ASC (apoptosis-associated speck-like protein containing a caspase activation and recruitment domain) and active caspase-1 in the RIAKI tissue compared to the healthy control. Our clinical findings identify…[Read more]

]]> 0 0b440fecf489e6b1d6d01d744e33688f Wilder Rasch posted an update: 42 μmol/L; 95 % CI -0.71 to -0.13), increased serum TAC (MD […] https://www.catswannabecats.com/activity/p/18010/ Tue, 03 Jun 2025 12:33:19 -0400 42 μmol/L; 95 % CI -0.71 to -0.13), increased serum TAC (MD 225.96 mmol/L; 95 % CI 68.42-383.5) and GSH levels (MD 49.99 μmol/L; 95 % CI 2.25 t 97.73), compared with the placebo group. In contrast, no significant changes were seen in NO levels following zinc supplementation (MD -1.66 μmol/L; 95 % CI -5.89 to 2.57). Dose-response analysis showed a…[Read more]

]]> 0 e014452321dcd947a90e10a244d26c57 Wilder Rasch posted an update: Multiple myeloma (MM) is an incurable hematological tumor, […] https://www.catswannabecats.com/activity/p/12936/ Sun, 01 Jun 2025 14:01:39 -0400 Multiple myeloma (MM) is an incurable hematological tumor, which is closely related to hypoxic bone marrow microenvironment. However, the underlying mechanisms are still far from fully understood. We took integrated bioinformatics analysis with expression profile GSE110113 downloaded from National Center for Biotechnology Information-Gene…[Read more]

]]> 0 94063256b340353714cfc5c83d16a98d Wilder Rasch posted an update: BST-2 is a novel driver of cancer progression whose […] https://www.catswannabecats.com/activity/p/6030/ Sat, 31 May 2025 15:42:20 -0400 BST-2 is a novel driver of cancer progression whose expression confers oncogenic properties to breast cancer cells. As such, targeting BST-2 in tumors may be an effective therapeutic approach against breast cancer. Here, we sought to develop potent cytotoxic anti-cancer agent using the second-generation BST-2-based anti-adhesion peptide, B18, as…[Read more]

]]> 0 4fcc36e54971992b1e3c75e54e5df44d Wilder Rasch became a registered member https://www.catswannabecats.com/activity/p/5875/ Sat, 31 May 2025 15:25:26 -0400 0