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Donaldson Wilkins posted an update 1 year ago
DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1a) is highly expressed in glioma, an aggressive brain tumor, and has been proposed as a therapeutic target for cancer. In the current study, we have used an optimized and validated time-resolved fluorescence energy transfer (TR-FRET)-based DYRK1A assay for high-throughput…[Read more]
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Sommer Ellis posted an update 1 year ago
g diverse pain conditions. C75 However, given the variety of study designs and reported treatment outcomes, conclusions about the evidence for eye acupuncture for specific conditions are not possible at this stage.
This randomized clinical trial aimed to compare the preparation time and severity of postoperative pain between HyFlex Electric…[Read more]
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Banks Birch posted an update 1 year ago
Tuberculosis (TB) is the most prevalent infectious disease in the world. In recent years there has been a significant increase in the incidence of TB due to the emergence of multidrug resistant strains of Mycobacterium tuberculosis (M. tuberculosis) and the increased numbers of highly susceptible immuno-compromised individuals. Central nervous…[Read more]
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Whitehead Gibbons posted an update 1 year ago
The ability to detect low concentrations of biomarkers in patient samples is one of the cornerstones of modern healthcare. In general, biosensing approaches are based on measuring signals resulting from the interaction of a large ensemble of molecules with the sensor. Here, we report a biosensor platform using DNA origami featuring a central…[Read more]
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Bunn Acosta posted an update 1 year ago
Glioblastoma multiforme (GBM) is the most malignant brain tumor. Hypoxic condition is a predominant feature of the GBM contributing to tumor growth and resistance to conventional therapies. Hence, the identification of drugs able to impair GBM malignancy and aggressiveness is considered of great clinical relevance. Previously, we demonstrated that…[Read more]
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Kragh Zhou posted an update 1 year ago
Dermatomyositis (DM) is an autoimmune disease that affects the skin, lungs, and muscle. Although the pathogenesis of DM is not completely understood, several environmental triggers have been linked to DM onset or flare. This article specifically examines the effects of herbal supplements, drugs, infections, ultraviolet (UV) radiation, and…[Read more]
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Sonne Bengtsen posted an update 1 year ago
The specific interactions among NOR-related genome structures remain unclear and require further investigation. Here, I propose that there are limited and non-limited genomic dispersion systems that result from genomic affinity rules, inducing specific chromosomal configurations that are related to NORs.The objective of this systematic review was…[Read more]
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Ebsen Somerville posted an update 1 year ago
She required a 2-stage revision procedure with massive allograft. At 1 year after these procedures, the patient is able to walk without a walking aid and does not report groin pain or present signs of dislocation, and radiographs show no loosening of the implant. CONCLUSIONS This case highlights that medial wall post-THA PIF can occur along with…[Read more]
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Albright Gundersen posted an update 1 year ago
Intense pulsed light (IPL) is becoming a new technical platform for disinfecting food against pathogenic bacteria. Metabolic changes are deemed to occur in bacteria as either the causes or the consequences of IPL-elicited bactericidal and bacteriostatic effects. However, little is known about the influences of IPL on bacterial metabolome. In this…[Read more]
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Sampson Conrad posted an update 1 year ago
10, p=1.96*10-20). The motif “QAD” of α44, β57, and β135 captured the T1D risk association of DQ8.1 (OR 3.44, p=3.80*10-84), the corresponding motif “CAD” captured the risk association of DQ2.5 (OR 2.10, p=1.96*10-20). Two risk associations were related to GADA and IA-2A, but in opposite directions. “CAD” was positively associated with GADA (OR 1.…[Read more]
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Koch Pape posted an update 1 year ago
Industrial biotechnology (IB) uses biological and biochemical processes in industrial production and is often regarded as an emerging key technology revolutionizing the production of many products while protecting resources and the environment and fostering economic development. This contribution describes the background and sketches the content…[Read more]
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Mathews Enemark posted an update 1 year ago
Gepotidacin (GSK2140944) is a first in class, novel triazaacenaphthylene bacterial type II topoisomerase inhibitor in Phase 3 clinical development for the treatment of gonorrhea and uncomplicated urinary tract infections (acute cystitis). This study tested the equivalency of minimal inhibitory concentrations (MICs) obtained by two reference…[Read more]
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Morton Washington posted an update 1 year ago
Clinical pharmacology is also applied in direct patient care with the goal of personalizing treatment. Tools such as therapeutic drug monitoring, pharmacogenomics and model informed precision dosing are used to optimize dosing for patients at an individual level. In KSA, the science of clinical pharmacology is underutilized and we believe it is…[Read more]
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Nilsson Chappell posted an update 1 year ago
There was an increasing trend of proliferative and cell growth related genes and shutting down of immune response as the disease progress mild to moderate to advanced stage cirrhosis. The myriad of changes in gene expression showed more chances of developing liver cancer in patients infected with HCV genotype 3a in a systematic manner. The…[Read more]
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Karlsson Lindsay posted an update 1 year ago
Our proposal can easily be extended to systems that include multiple quantum emitters interacting through hyperbolic metasurfaces and thus may have potential applications in on-chip science that aims at quantum information processing and quantum networks.Speckle-correlation imaging is a family of methods that makes use of the “memory effect” to…[Read more]
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Paaske Dotson posted an update 1 year ago
Therefore, it is critical that multidisciplinary service providers, including health professionals, employers, social services providers, educational institutions and community organizations, move toward online service delivery, so that homebound HIV-positive LGBT+ individuals are secured with a wide range of care options. Non-judgemental,…[Read more]
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Nance May posted an update 1 year ago
A basic paradigm underlying the Hookean mechanics of amorphous, isotropic solids is that small deformations are proportional to the magnitude of external forces. However, slender bodies may undergo large deformations even under minute forces, leading to nonlinear responses rooted in purely geometric effects. Here we study the indentation of a…[Read more]
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Morin Cooper posted an update 1 year ago
In addition, the results of clinical studies showed that TXYF has good efficacy and few adverse reactions in the treatment of UC. Although it has achieved some success, the research is limited by deficiencies; there is a lack of unified standards for the construction of UC animal models and for administration regimen. In addition, the dosage of…[Read more]
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Allen Rooney posted an update 1 year ago
ignificantly increased the facet joint pressure and decreased the range of motion; therefore, it should not be used in clinical practice.
This study suggested that an appropriate artificial disc height can achieve near-normal biomechanical properties and is recommended. We should be very cautious when using artificial discs ≥ 1 mm in heigh…[Read more]
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Madden Stage posted an update 1 year ago
26±0.114, 1.05±0.181, and 0.59±0.074MPa, respectively. The periods of time needed to achieve effective thrombolysis were measured at 0.8, 2, and 4mJ/cm
laser fluence levels and 0.42, 0.70, and 0.98MPa negative ultrasound pressures. In general, thrombolysis could be achieved more rapidly with higher laser powers or ultrasound pr…[Read more]
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