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Duke Ahmed posted an update 1 year ago
Cardiovascular disease is currently the leading cause of death worldwide, and its underlying regulatory mechanisms remain largely unknown. N6-Methyladenosine (m6A) RNA methylation is an epigenetic modification involved in the splicing, nuclear export, translational regulation, and degradation of RNA. After the initial identification of m6A RNA…[Read more]
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Anker Thomson posted an update 1 year ago
This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19 (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural…[Read more]
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Daly Tran posted an update 1 year ago
After viewing the first and second VR, subjects responded to STAI and the numerical rating scale (NRS) for satisfaction and side effects (nausea, dizziness, headache, and tiredness). Results Ten subjects participated in this study. The values of analyses are presented in the mean (SD). The age was 87.1 years (4.2), and the MMSE was 28.5 (1.8). sell…[Read more]
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Cobb Kirkegaard posted an update 1 year ago
7±0.3, S/B = 21±2.1, Z’ = 0.75±0.04. Pilot screen of FDA-approved drug library (n=1,400 compounds) demonstrated hit rate of 0.5%. Two compounds demonstrated pharmacological response and were authenticated by western blot analysis.
We developed a highly robust HTS-amenable high content screening assay capable of monitoring down re…[Read more]
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Covington Maldonado posted an update 1 year ago
Obsessive-compulsive symptoms (OC) are associated with greater morbidity and worse prognosis in anorexia nervosa (AN). We assessed the presence of non-eating OC in participants with AN and related them with their psychopathology, personality, and attachment style features.
Young women with AN (N = 41, 30 restrictor and 11 binge-purging typ…[Read more]
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Bauer Price posted an update 1 year ago
ent of apical prolapse have comparable results with high clinical success rates.
Vaginal colposuspension using the Uphold Lite system and VUSLS for the treatment of apical prolapse have comparable results with high clinical success rates.Lipid droplet (LD) is a vital organelle governing lipid homeostasis and Rab18 has been linked to lipid…[Read more]
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Velez Kejser posted an update 1 year ago
Prognostic factors were identified and research questions for future clinical trials were addressed.
Prognostic factors were identified and research questions for future clinical trials were addressed.
As next-generation sequencing (NGS) technology matures, various amplicon-based NGS tests for BRCA1/2 genotyping have been introduced. This…[Read more]
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Anker Lohse posted an update 1 year ago
To enable an interactive search for combinations of protocol elements, CLIPS provides optional next element selection according to the previous element in the form of a connected tree. The validation results show that our method achieves better performance than that of existing databases in predicting phenotypic features.Social distancing…[Read more]
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Axelsen Acevedo posted an update 1 year ago
Smoking is associated with incident heart failure (HF), yet limited data are available exploring the association between smoking status and long-term outcomes in HF with reduced vs. preserved ejection fraction (i.e., HFrEF vs. HFpEF).
We performed a retrospective analysis of HF patients undergoing coronary angiography from 1990-2010. Patients…[Read more]
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Gardner Watson posted an update 1 year ago
Sexuality is one of the fundamental mechanisms that work towards maintaining genetic diversity within a species. In diploid persimmons (Diospyros spp.), separated sexuality, the presence of separate male and female individuals (dioecy), is controlled by the Y chromosome-encoded small-RNA gene, OGI. On the other hand, sexuality in hexaploid…[Read more]
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Bay Eriksen posted an update 1 year ago
Implications The skepticism and critical analysis encouraged by EBM can and should be applied to the underlying assumptions and primary tenets of EBM itself. It is not enough for philosophers to partake in this endeavor; students, trainees, and clinicians need to carefully and constantly examine the reasons and reasoning that coalesce into…[Read more]
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Konradsen Lemming posted an update 1 year ago
g pathologically proven HCC lesions not meeting LI-RADS criteria for definitive HCC (LR5) can correctly differentiate HCC lesions from other liver malignancies, potentially expanding the role of image-based diagnosis in primary liver cancer with atypical features. Mocetinostat • The trained CNN demonstrated an overall accuracy of 87.3% and a c…[Read more]
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Karstensen Greer posted an update 1 year ago
Both ICOS and LAG-3 were found to be significantly associated with improved overall survival in The Cancer Genome Atlas (TCGA) ovarian cancer cohort. Finally, PVRL2 was identified as the most highly expressed transcript in our analysis, with immunohistochemistry results confirming its overexpression in HGSOC samples compared to normal/benign.…[Read more]
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Haagensen Frandsen posted an update 1 year ago
To investigate whether providing athletes with a choice regarding the number of repetitions to complete in a potentiation protocol would enhance jumping performance compared with protocols in which the number of repetitions is predetermined.
Fifteen male basketball players completed 4 testing sessions separated by 72 hours. In the first…[Read more]
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Franklin Parks posted an update 1 year ago
gen fertiliser adaptation.On December 13, 2019, the Yale School of Public Health hosted a symposium titled “Per- and Polyfluoroalkyl Substances (PFAS) Challenges and Opportunities” in New Haven, Connecticut. The meeting focused on the current state of the science on these chemicals, highlighted the challenges unique to PFAS, and explored promising…[Read more]
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Perry Hesselberg posted an update 1 year ago
The novel SLA apparatus was subsequently used to conduct a high throughput screening of 156 placebo photopolymer formulations. The efficiency of the equipment and formulation printability outcomes were evaluated. Improved time and cost efficiency by 91.66% and 94.99%, respectively, has been confirmed using the modified SLA apparatus to deliver…[Read more]
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Yde Malloy posted an update 1 year ago
Putting a name to a face is a highly common activity in our daily life that greatly enriches social interactions. Although this specific person-identity association becomes automatic with learning, it remains difficult and can easily be disrupted in normal circumstances or neurological conditions. To shed light on the neural basis of this…[Read more]
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Friedman Lee posted an update 1 year ago
These findings highlight that targeting HO-1-mediated RPE ferroptosis could serve as an effectively retinal-protective strategy for retinal degenerative diseases prevention, including AMD.Loss of perivascular adipose tissue (PVAT) impairs endothelial function and enhances atherosclerosis. However, the roles of PVAT thermoregulation in vascular…[Read more]
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Gammelgaard Landry posted an update 1 year ago
Thus, nucleation coordinates mechanical and chemical timescales to encode shape memory into active materials.In the 50s and 60s, before burn centres appeared, burn patients were primarily treated in surgical departments. They were then referred to sanatorium-type institutions, moving towards functional rehabilitation but without a really…[Read more]
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Cummings Vedel posted an update 1 year ago
BACKGROUND A Mediterranean-style eating pattern is consistently associated with a decreased diabetes risk in Mediterranean and European populations. However, results in U.S. populations are inconsistent. The objective of this study was to assess whether a Mediterranean-style eating pattern would be associated with diabetes risk in a large,…[Read more]
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