• Results This review found much evidence for the use of inorganic nanoparticles for PTT-based combinational cancer therapy. Conclusion Under synergistic effects, inorganic nanomaterial-based combinational treatments exhibit enhanced therapeutic effects compared to PTT, CHT, RT, IT or PDT alone and should be further investigated in the cancer field.…[Read more]

  • In a changing environment, organisms need to decide when to select items that resemble previously rewarded stimuli and when it is best to switch to other stimulus types. Here, we used chemogenetic techniques to provide causal evidence that activity in the rodent anterior cingulate cortex and its efferents to the anterior thalamic nuclei modulate…[Read more]

  • Thus, this work provides an important method for designing other metal-organic framework-derived three-dimensional structural sulfide quantum dot multifunctional electrocatalysts for wider application in highly efficient catalysis and energy storage.The tailored spatial polarization of coherent light beams is important for applications ranging…[Read more]

  • Older adults frequently under-report depressive symptoms and often fail to access services after a disaster. To address unmet mental health needs, we developed a service delivery program (SMART-MH) that combines outreach, assessment, and therapy and implemented it in New York City after Hurricane Sandy. This study aimed to examine the feasibility,…[Read more]

  • Using long-term mortality surveillance data from Taï National Park, we provide evidence of little to no prior viral activity over at least two decades. We conclude that great ape sentinel systems devoted to the longitudinal collection of behavioural and health data can help clarify the epidemiology and clinical presentation of zoonotic…[Read more]

  • elected older patients represent a significant larger proportion in real life than in RCTs; furthermore, older patients in a real-world setting may experience more side effects possibly affecting the quality of life. The median PFS data suggest that older patients may not derive the same clinical benefit than their fit and younger…[Read more]

  • This study examined whether intranasal oxytocin enhances the stress-buffering effects of social support during experimentally induced pain, taking into account the role of individual differences in attachment security.

    Female participants (N=193) were randomly assigned to oxytocin (24IU intranasal) or placebo and to receive support or no…[Read more]

  • In addition, lapachol increased the expression level of TIMP-1 compared with PMA treatment group. Moreover, lapachol decreased the expression level of p-p38 among MAPKs compared with PMA treatment group. It was also found that the expression level of p65, a part of NF-kB, in nuclei was reduced in the presence of lapachol above 0.5 µM compared…[Read more]

  • The toxicity characteristics of HBCD and resistance mechanism of flavonols are investigated based on physiological and metagenomic analysis. Toxicology research of HBCD on Arabidopsis thaliana (Col and fls1-3) not only shows the toxic effect of HBCD on plants, but also indicates that flavonols could improve plant resistance to HBCD, including root…[Read more]

  • Administration of Mexidol or Semax was associated with preservation of the neuron number and neuronal expression of PGC-1α, stimulation of the nuclear translocation of PGC-1α, and increased contents of protein markers for PGC-1α activation. This study opens new prospects for the pharmacological modulation of PGC-1α in the ischemic bra…[Read more]

  • Yang Rafn posted an update 7 months, 4 weeks ago

    Thirteen patients (34.2%) underwent either another operation due to the lack of resolution of their AC-related symptoms or secondary to complications directly related to their initial surgery. Average length of followup from time of first operation was 84.1 months. Overall, our results demonstrate similarities in epidemiology, clinical…[Read more]

  • This study shows that women who take up screening are older, more knowledgeable regarding cervical cancer and screening, less likely to perceive screening barriers, and more likely to perceive cervical cancer as a severe disease. This highlights that for public health interventions to increase screening uptake, the focus should include tailored…[Read more]

  • Additionally, the redox behaviour of Cu produced more carboxyl groups, which increased the adsorption of heavy metals. The ecological impact of this method was also examined; we found that the influences of leaching with EPS on soil properties and microbial community structure were slight. Therefore, the reported leaching process might have…[Read more]

  • We aimed to investigate the topographic correspondence between deep-layer microvasculature dropout (MvD) and retinal nerve fibre layer (RNFL) defects in eyes with open-angle glaucoma (OAG) using spectral-domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCT-A).

    Microvasculature dropout width and…[Read more]

  • Glycosylation of proteins plays important roles in the occurrence and development of chronic diseases. In this study, we report an enrichment method of intact N-glycopeptides using a magnetic polyaniline nanomaterial (Fe3O4@PANI). Under the synergistic effect of hydrogen bonding and electrostatic adsorption, Fe3O4@PANI can rapidly and easily…[Read more]

  • Dome-shaped macula is a relatively new entity, which has been mainly described in highly myopic adults. Since its description, an increasing number of studies have been published to help characterise this condition and to elucidate its nature, causes, epidemiology and associated findings. Although the majority of the available data relate to…[Read more]

  • Our results suggested that obacunone derivatives play an important role on anti-inflammation of Baixianpi. As a representative among them, DAS showed a strong anti-inflammatory activity via suppressing NF-κB signaling pathways.The current body of literature points monoterpenes as one of the determinant factors of the interaction between forests…[Read more]

  • s.

    Very good to excellent quality evidence indicated that the SANE scale demonstrates evidence of a reliable, valid and responsive tool in patients with shoulder related pathologies.

    PROSPERO CRD42018117874.

    PROSPERO CRD42018117874.This paper argues that diverse disciplines within the human sciences have converged in identifying…[Read more]

  • Foxtail millet (Setaria italica) is an excellent source of beneficial natural fatty acids and phytosterols. However, the mechanisms underlying the dynamic changes of fatty acids and phytosterols during seed development are unknown. In this study, a comprehensive dynamic change analysis of the bioactive compounds during seed development was…[Read more]

  • The proposals herein reported may be used to guide the practical use of NGS for BCR-ABL1 KD mutation testing in Ph+ ALL. © 2020 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.Takotsubo syndrome (TTS), also referred to as stress cardiomyopathy, is characterized by transient left ventricular apical ballooning in the absence of…[Read more]

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