-
Hartvig Hardy posted an update 8 months ago
TRV130 (oliceridine), a G protein-biased ligand for μ-opioid receptor, has recently been synthesized. It is considered to have strong antinociceptive effects and only minor adverse effects. However, whether or not oliceridine actually exhibits an ideal pharmacological profile as an analgesic has not yet been fully clarified in animal studies.…[Read more]
-
Owen Gravgaard posted an update 8 months ago
Introduction Fabry disease (FD) is an X-linked lysosomal storage disorder characterized by a deficiency or absence of alpha-galactosidase A (α-GAL A) enzyme, where stroke can be a serious complication. The aim of this study is to determine the feasibility of centralized screening for FD, among young stroke adults registered in the national…[Read more]
-
Vick Lee posted an update 8 months ago
Cowpea (Vigna unguiculata (L.) Walp) is an important multipurpose legume crop grown in arid and semi-arid areas of sub-Saharan Africa. The crop associates with a wide diversity of high ecological value rhizobia bacteria, improving biological soil fertility and crop production. Here, we evaluated the symbiotic efficiency (SE) and genetic diversity…[Read more]
-
Berthelsen Horton posted an update 8 months ago
These inflammatory components form a common thread that is involved in regulation of the three plasticity levels stemness/EMT, therapy resistance, and dormancy. In view of the fact that inflammatory elements are a common denominator shared by different aspects of tumor cell plasticity, it is possible that their targeting may have a critical…[Read more]
-
Zachariassen Kamp posted an update 8 months ago
Patients with premature surges had significantly lower ovarian reserve as compared to the controls (as seen from their higher age group, higher day 2 follicle-stimulating hormone (FSH), lower antral follicle counts, and lower anti-Müllerian hormone).
Premature LH surge in a GnRH-antagonist cycle can lead to cycle cancellation and…[Read more]
-
Morse Martinsen posted an update 8 months ago
The introduction of N6-methyladenosine (m6 A) into siRNA targeting Factor VII impacts its potency in cells and has a significant influence on the selectivity of siRNA, including reduced off-targeting. These effects are dependent on the position of m6 A in the siRNA duplex, with some of the sequences identified as more potent and/or selective tha…[Read more]
-
Thomassen Soto posted an update 8 months ago
A background study is important for the conservation and stock management of a species. Terapon jarbua is a coastal Indo-Pacific species, sourced for human consumption. This study examined 134 samples from the central west and east coasts of Peninsular (West) Malaysia and East Malaysia. A 1446-bp concatenated dataset of mtDNA COI and Cyt b…[Read more]
-
Lim Swanson posted an update 8 months ago
Application of 8-Br at the end of ischaemia protected the heart during reperfusion. 8-Br promoted binding of HKII to the mitochondria and reduced Ca2+-induced mitochondria swelling. Thus, 8-Br protects the heart when administered before regional ischaemia or at the beginning of reperfusion. This effect is associated with inhibition of MPTP via…[Read more]
-
Eriksson Hahn posted an update 8 months ago
Predicting the phenotypes resulting from molecular perturbations is one of the key challenges in genetics. Both forward and reverse genetic screen are employed to identify the molecular mechanisms underlying phenotypes and disease, and these resulted in a large number of genotype-phenotype association being available for humans and model…[Read more]
-
Bork Upton posted an update 8 months ago
Sales surveillance is considered essential for data retrieval on a global scale and inter-country comparison. However, the usability of a surveillance system based on sales data for risk management of antimicrobial resistance has limitations. The German system does not include off-label use of antimicrobial products authorized for human medicine…[Read more]
-
Hatch Rossen posted an update 8 months ago
Multiple dipeptidyl-peptidases (DPPs) are present in the periplasmic space of Porphyromonas gingivalis, an asaccharolytic periodontopathic bacterium. Dipeptides produced by DPPs are presumed to be transported into the bacterial cells and metabolized to generate energy and cellular components. The present study aimed to identify a transporter…[Read more]
-
Duncan Collins posted an update 8 months ago
These bioactive agents did not enhance the new bone formation significantly under the conditions tested, according to micro-computed tomography and histological analysis.Most cases of stroke associated with coronavirus disease 2019 (COVID-19) occur during the course of a characteristic COVID-19 respiratory illness. We report three patients where…[Read more]
-
Vargas Carrillo posted an update 8 months ago
A family of helical dinuclear copper(i) pyridylphospholane complexes X (X = BF4-, Cl- and Br-) was prepared. The family includes the first examples of this type of complex based on copper(i) chloride and copper(i) bromide. The two isomers typical of this class of compounds, namely head-to-head and head-to-tail complexes, were studied in solution…[Read more]
-
Fox Hester posted an update 8 months ago
e socio-behavioural characteristics including negative dental care seeking. This highlights the importance of tailoring regular contacts with dental healthcare services in childhood to build confidence in children and thus has implications for healthcare policy.
Unpleasant dental care experiences during childhood are associated with poor oral…[Read more]
-
Skaarup Shelton posted an update 8 months ago
1% to 6.1%], using 450-ml glasses was 1.0% higher (95% CI = -9.1 to 12.2) and using 510-ml glasses was 0.4% lower (95% CI = -9.4 to 9.4). For restaurants, compared with 300-ml glasses, the volume of wine sold using 250-ml glasses did not show a significant difference 9.6% lower (95% CI = -19.0 to 0.7). Using 370-ml glasses the volume of wine sold…[Read more]
-
Bowden Regan posted an update 8 months ago
State-of-the-art next-generation sequencing (NGS)-based subclonal reconstruction methods perform poorly on somatic copy number alternations (SCNAs), due to not only it needs to simultaneously estimate the subclonal population frequency and the absolute copy number for each SCNA, but also there exist complex bias and noise in the tumor and its…[Read more]
-
David Knowles posted an update 8 months ago
Hepatitis A virus (HAV) infections continue to represent a significant disease burden causing approximately 200 million infections, 30 million symptomatic illnesses and 30,000 deaths each year. Effective and safe hepatitis A vaccines have been available since the early 1990s. Selleckchem OTSSP167 Initially developed for individual prophylaxis, HAV…[Read more]
-
Boye Johannessen posted an update 8 months ago
Six of 8 surgeons were from Kenya. The mean precourse test score was 25 (range 21-30) compared to a mean postcourse test score of 40 (range 37-45, p less then 0.005). All participants significantly improved their scores, with a mean improvement of 16 points (range 10-23). DISCUSSION Otolaryngologists are uniquely equipped to learn head and neck…[Read more]
-
Reece Brewer posted an update 8 months ago
Autosomal dominant tubulointerstitial disease (ADTKD) is a dominantly inherited progressive nonglomerular disease. Several factors, such as a nonspecific clinical presentation and relative rarity, impede the phenotyping of ADTKD into clinically relevant subtypes and impair the appropriate implementation of genetic testing. The study by Olinger et…[Read more]
-
Leblanc Fournier posted an update 8 months ago
ISA lab-based standard.
Diabetes is one of the global health emergencies of the 21st century. This study sought to assess self-care behaviours, glycaemic control and health-related quality of life (HRQoL) of type 2 diabetes patients at a Nigerian hospital, determine factors associated with HRQoL, and assess the inter-relationship among these…[Read more]
- Load More