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Salisbury Bengtsen posted an update 8 months ago
In chronic pancreatitis, PSCs are activated by proinflammatory cytokines to induce pancreatic fibrogenesis. HDAC inhibition protected against the pancreatic fibrosis and the apoptosis of PSCs through induced apoptosis and depressed inflammation. In our study, we found that miR-15 and miR-16 decreased significantly in chronic pancreatitis and HDAC…[Read more]
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Poole Carr posted an update 8 months ago
GABAA receptor agonist phenobarbital could rectify the decrease of BrdU+/NeuN+ cells in PRS mice. PRS mice also showed an increased expression of DNA methyltransferase 1 (DNMT1) and an increased binding of DNMT1 to GAD67 promoter region. The treatment with DNMT1 inhibitor 5-aza-deoxycytidine restored the decrease of BrdU+/NeuN+ cells and…[Read more]
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Reynolds Bean posted an update 8 months ago
armigera. Our findings revealed that the microbiota plays an important role in modulating the resistance of H. armigera to baculovirus infection, providing new insights in applying biopesticide.In Japan, oral administration of tegafur-uracil is recommended as postoperative adjuvant chemotherapy for patients diagnosed with primary lung…[Read more]
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Mcfarland Silverman posted an update 8 months ago
ntify innate immune response genes in flounder that are commonly modulated by IHNV, VHSV, and HIRRV. These data will provide new insights into how novirhabdoviruses survive the innate immune response of flounder cells.To mitigate the movement of non-native organisms with trade, phytosanitary systems have been implemented within and between…[Read more]
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Brady Abdi posted an update 8 months ago
Several technologies have been employed to treat greywater (GW) for domestic use. Aerobic biological treatment has achieved high efficiency, the main cost being the necessary source of oxygen (O2). This study explores the effects of lumen air pressure (LAP) on reactor performance and microbial community succession in an O2-based membrane biofilm…[Read more]
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Brennan Dogan posted an update 8 months ago
The research explored the influence of spiritual coping and social support on mental health and quality of life (QOL) of informal caregivers of stroke survivors in Saudi Arabia. The respondents were frequently using religious coping strategies than existential coping strategies. The respondents received higher support from significant others and…[Read more]
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Valentin Molloy posted an update 8 months ago
Twelve compounds showed an interesting antiproliferative potential with IC50 from 23.2 to 95.9 µM. The flow cytometric analysis results showed that hit 4 induces the apoptosis in MCF-7 cells with a significant 26.86% reduction in cell viability. The in vivo study revealed a significant decrease in the solid tumor mass (26.6%) upon treatment with…[Read more]
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Porter Chandler posted an update 8 months ago
Background Heterogeneity should be carefully addressed to facilitate establishment of effective population-level blood lipid management. The primary aim of the study was to investigate gender heterogeneity in prevalence of dyslipidemia, including trends with age and associated factors in middle age rural Chinese. Methods This is a cross-sectional…[Read more]
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Davidsen Jokumsen posted an update 8 months ago
Cancer cells are characterized by the Warburg effect, a shift from mitochondrial respiration to oxidative glycolysis. We report here the crucial role of cyclin D1 in promoting this effect in a cyclin-dependent kinase (CDK)4/6-independent manner in multiple myeloma (MM) cells. We show that the cyclin D1 oncoprotein targets hexokinase 2 (HK2), a…[Read more]
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Tyler Rivas posted an update 8 months ago
Guys as Health care worker Anesthetists.
The rainfall and distribution of rainwater drains explain the monthly and spatial variations of contribution of NO3–N sources well, respectively. In addition, less NO3–N in the urban channels derives from nitrification, which is consistent with the results of high properties of NH4+-N/TN in this…[Read more]
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Morris Hoffman posted an update 8 months ago
These activities have a huge impact on improving the quality of life of people with disabilities.This study intended to address the problem of damaged (collapsed, cracked and decreased soil strength) road pavement structure built on clay soil due to clay soil properties such as low shear strength, high soil compressibility, low soil permeability,…[Read more]
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Aguilar Jokumsen posted an update 8 months ago
A layered porous organic framework (L-POF) with high surface area and porous volume was used as a novel adsorbent for adsorption of chlorophenols (CPs). The L-POF showed much higher adsorption capacity for four CPs (2-CP, 3-CP, 2,3-CP, 2,4-CP) compared with corresponding amorphous POF and some commercial adsorbents. Then, an L-POF-based…[Read more]
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Mack Rosa posted an update 8 months ago
This paper presents two studies on the development and validation of a ten-item scale of epistemic vice and the relationship between epistemic vice and misinformation and fake news. Epistemic vices have been defined as character traits that interfere with acquiring, maintaining, and transmitting knowledge. Examples of epistemic vice are…[Read more]
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Boll Tanner posted an update 8 months ago
This research sheds light on the potential molecular mechanisms underlying the effects of PN on stroke recovery.Kaposi’s sarcoma (KS) is an angioproliferative malignancy whose associated etiologic agent is the Kaposi’s sarcoma-associated herpesvirus (KSHV). KS is the most prevalent malignancy among HIV-infected individuals globally and is…[Read more]
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McGuire Gentry posted an update 8 months ago
Inositol-1,4,5-triphosphate (IP3) kinase B (ITPKB) is a ubiquitously expressed lipid kinase that inactivates IP3, a secondary messenger that stimulates calcium release from the endoplasmic reticulum (ER). Genome-wide association studies have identified common variants in the ITPKB gene locus associated with reduced risk of sporadic Parkinson’s…[Read more]
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Spencer Sampson posted an update 8 months ago
The high-throughput sequencing analysis indicated that the dominant phyla (e.g. Firmicutes and Bacteroidetes) were more abundant using the MIC reactor than with the UASB reactor, which may indicate WHJ degradation efficiency. Both reactors had similar predominant methanogens, suggesting that acetoclastic methanogenesis was the predominant…[Read more]
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Sweet Hatfield posted an update 8 months ago
ity of oral anticancer agents cause QT prolongation with direct and indirect mechanisms, potentially resulting in the occurrence of torsade de pointes, especially in susceptible patients with COVID-19 receiving additional drugs with QT liability. Oncologists and cardiologists must be aware of the increased bleeding risk and arrhythmic…[Read more]
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Wentworth Risager posted an update 8 months ago
The determined crystal structure of the Syntaxin17 LIR-GABARAP complex not only provides mechanistic insights into the interaction between Syntaxin17 and GABARAP but also reveals an unconventional LIR motif with a C-terminally extended 310 helix for selectively binding to ATG8 family proteins. Finally, we also elucidated structural arrangements of…[Read more]
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MacGregor Milne posted an update 8 months ago
Results With ART criteria, success rates of ART and composite restoration were found to be 98.7% and 100% at 6 months while at 12 months the success rates were observed to be 98.7% and 95.8%, respectively. The distribution of scores at both the time periods was found to be statistically significant (p = 0.033). Same success rates were observed…[Read more]
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Covington Oneil posted an update 8 months ago
In Chile, necrotizing enterocolitis (NEC) mainly affects preterm infants, with an incidence of 0.3 to 2.4 per 1,000 live births, and 8 to 12% in preterm infants weighing less than 1,500 grams.
To describe health professionals perceptions on the use of human colostrum as a preventive measu re against necrotizing enterocolitis in preterm…[Read more]
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