• Mcneil Slaughter posted an update 8 months ago

    In veterinary and human medicine, gabapentin (a chemical analog of γ-aminobutyric acid) is commonly prescribed to treatpostoperative and chronic neuropathic pain. This study explored the pharmacokinetics of oral and subcutaneous administrationof gabapentin at high (80 mg/kg) and low (30 mg/kg) doses as a potential analgesic in black-tailed…[Read more]

  • Kjeldgaard Shelton posted an update 8 months ago

    HIV-1 Gag p24 has long been identified as an informative biomarker of HIV replication, disease progression, and therapeutic efficacy, but the lower sensitivity of immunoassays in comparison to molecular tests and the interference with antibodies in chronic HIV infection limit its application for clinical monitoring. The development of…[Read more]

  • Lake Krogh posted an update 8 months ago

    6% (2/30) of apparently de novo cases.

    The search for parental somatic mosaicism should be routinely implemented in de novo cases of MFS, to offer appropriate genetic and reproductive counselling as well as to reveal masked, isolated clinical signs of MFS in progenitors that may require specific follow-up.

    The search for parental…[Read more]

  • Dencker Bonde posted an update 8 months ago

    In many mammals, genomic sites for recombination are determined by the histone methyltransferase PRMD9. Some mouse strains lacking PRDM9 are infertile, but instances of fertility or semifertility in the absence of PRDM9 have been reported in mice, canines, and a human female. Such findings raise the question of how the loss of PRDM9 is…[Read more]

  • Whitehead Thorsen posted an update 8 months ago

    1 ± 2.9 versus 5.7 ± 3.4 (P = 0.600). In the propensity score-matched cohort (n = 22 per group), the number of oocytes retrieved was significantly lower in the patients with endometrioma undergoing fertility preservation compared with that in infertile patients without endometrioma (5.4 ± 3.8 versus 8.1 ± 4.8; P = 0.045). A total of 13 (38.2%) p…[Read more]

  • Lowery Timm posted an update 8 months ago

    15). Children with anisometropic amblyopia have reduced macular vessel density in OCTA, while no difference of macular vessel density was found between the recovered amblyopic and control eyes. Macular thickness showed no difference in anisometropic amblyopia and remained unchanged after amblyopic treatment.Once an epidemic outbreak has been…[Read more]

  • Newman Tolstrup posted an update 8 months ago

    In conclusion, T. canis larval migration activated the MMPs and caused pulmonary pathogenesis.

    These phenomena subsequently induced the activities of MMPs in parallel with the pathological changes in early stage pulmonary inflammation. In conclusion, T. canis larval migration activated the MMPs and caused pulmonary pathogenesis.

    Respiratory…[Read more]

  • McDaniel Lindsey posted an update 8 months ago

    Understanding the epidemiology of SARS-CoV-2 is essential for public health control efforts. Social, demographic, and political characteristics at the US county level might be associated with changes in SARS-CoV-2 case incidence.

    We conducted a retrospective analysis of the relationship between the change in reported SARS-CoV-2 case counts…[Read more]

  • Mccarthy Bryant posted an update 8 months ago

    Injury of lower cranial nerves (CNs) by skull base fracture after head trauma can occur sometimes. However, selectively different CN damage on either side is extremely rare. A 53-year-old man had difficulty of swallowing, phonation, and articulation after falling off his bicycle. In physical examination, a deviated tongue to the right side was…[Read more]

  • Focusing primarily on clinical research, this review first defines the gut-brain axis, then details age-related GI and nervous system changes, and discusses the impact of age-related lifestyle factors on the GI and nervous systems. The remainder of this review describes cutting-edge research that positions the gut microbiota as an arbiter of…[Read more]

  • Owen Bowen posted an update 8 months ago

    This review describes an overview of the microbial reduction of Cr6+, resistance mechanism, and the antioxidant profiling exhibited by these microorganisms when exposed to Cr6+. It also describes the pilot-scale study of the successive use of bacterial, fungal, and algal strains and the subsequent use of microbially purified water for the…[Read more]

  • Griffin Albright posted an update 8 months ago

    The article extends the discussion on the challenges in gaining access to the field in medical ethnographic research, focusing on long-term care (LTC) facilities. Medical institutions have been documented to be difficult sites to access. The reference, however, is to the recruitment of patients as informants. The challenges of recruiting…[Read more]

  • Lopinavir/ritonavir, originally developed for treating HIV, is currently undergoing clinical studies for treating the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although recent reports suggest that lopinavir exhibits in vitro efficacy against SARS-CoV-2, it is a highly protein-bound drug and it remains unknown if it reaches…[Read more]

  • Andreassen Penn posted an update 8 months ago

    ected nationwide) revealed in this survey could help the development of mitigation strategies to reduce public health risks associated with consumption of these nuts.

    Several studies have recently addressed factors associated with severe Coronavirus disease 2019 (COVID-19); however, some medications and comorbidities have yet to be evaluated…[Read more]

  • While significant racial inequities in health outcomes exist in the United States, these inequities may also exist in healthcare processes, including the Emergency Department (ED). Additionally, gender has emerged in assessing racial healthcare disparity research. This study seeks to determine the association between race and the number and type…[Read more]

  • Munkholm Gonzales posted an update 8 months ago

    The ventromedial nucleus of the hypothalamus (VMN) is involved in the counterregulatory response to hypoglycemia. VMN neurons activated by hypoglycemia (glucose-inhibited neurons) have been assumed to play a critical although untested role in this response. Here, we show that expression of a dominant negative form of AMPK or inactivation of AMPK…[Read more]

  • Mullen Mejia posted an update 8 months ago

    Together, these data establish myeloid KLF2 as a nodal regulator of central and peripheral metabolic inflammation in homeostasis and disease.Mechanical forces are integral to cellular migration, differentiation and tissue morphogenesis; however, it has proved challenging to directly measure strain at high spatial resolution with minimal…[Read more]

  • Hassing Baird posted an update 8 months ago

    OBJECTIVE This study tested the initial and continued effects of cancer warning labels on drinkers’ recall and knowledge that alcohol can cause cancer. METHOD A quasi-experiment was conducted to examine changes in the intervention versus comparison site for three outcomes unprompted and prompted recall of the cancer warning, and knowledge that…[Read more]

  • Stryhn Browning posted an update 8 months ago

    The working conditions of hospital care workers should be improved. Hospital care workers need improved status, increased rewards, and channels for further training and opportunities for continued career advancement.

    The working conditions of hospital care workers should be improved. Hospital care workers need improved status, increased…[Read more]

  • Lauesen Banke posted an update 8 months ago

    To reduce the likelihood of low birth weight, a multifaceted strategy should include enhancements in antenatal care, effective smoking cessation programs, optimized high-risk pregnancy care protocols, and carefully regulated assisted reproductive technologies.

    In infant care, problems frequently arise from sleep disorders in infants and…[Read more]

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