• Wooten Murdock posted an update 8 months ago

    This review is tailored to outline the known effects of the current anti-diabetic drugs, anti-inflammatory therapies, and natural compounds on inflammation, which mitigate HF progression in diabetic populations.Metabolic syndrome is associated with hypercholesterolemia, cardiac remodeling, and increased susceptibility to ventricular arrhythmias.…[Read more]

  • Palmer Reeves posted an update 8 months ago

    Alzheimer’s disease (AD) is the most common age-related progressive neurodegenerative disease, characterized by a decline in cognitive function and neuronal loss, and is caused by several factors. Numerous clinical and experimental studies have suggested the involvement of gut microbiota dysbiosis in patients with AD. The altered gut microbiota…[Read more]

  • Yde Malloy posted an update 8 months ago

    This article reviews four emerging endovascular hemorrhage control and extracorporeal perfusion techniques for management of trauma patients with profound hemorrhagic shock including hemorrhage-induced traumatic cardiac arrest. These include resuscitative endovascular balloon occlusion of the aorta (REBOA), selective aortic arch perfusion (SAAP),…[Read more]

  • Gould Rafn posted an update 8 months ago

    This proof-of-concept-study demonstrated the usability and reproducibility of Nephroscreen for the detection of DIKI and drug-transporter interactions. Nephroscreen it represents a valuable tool towards replacing animal testing and supporting the 3Rs (Reduce, Refine and Replace animal experimentation).

    Polysorbates (PS) are used in…[Read more]

  • Randall Hougaard posted an update 8 months ago

    argeting miR-211-5p and the downstream gene ACSL4 will possibly provide novel insight and represents a promising approach to future therapy of HCC patients.

    Targeting miR-211-5p and the downstream gene ACSL4 will possibly provide novel insight and represents a promising approach to future therapy of HCC patients.

    Revision ankle-fusion…[Read more]

  • Mays Upchurch posted an update 8 months ago

    0001).In patients with early ISR lesions, the LDL-C levels may be related to the formation and progression of early neoatherosclerosis, and poor LDL-C control may be a risk factor for the occurrence of early-stage neoatherosclerosis following DES implantation.Previous study has identified marked differences in patient characteristics and causes of…[Read more]

  • Bonner Clifford posted an update 8 months ago

    In some countries, including China, primary health care is rarely utilized because of medical personnel shortages at primary medical and health care institutions (PMHCIs). Several studies suggest that the most effective solution is to guide qualified doctors and medical graduates to work in PMHCIs, but the studies and measures have been formulated…[Read more]

  • Hassan Staal posted an update 8 months ago

    Currently, clinical treatment for temozolomide (TMZ)-resistant glioblastoma multiforme (GBM) is still a difficult problem. The aim of this paper is to set up a new GBM-targeted drug delivery system to treat TMZ-resistant GBM. Zoledronate (ZOL) not only induces apoptosis of TMZ-resistant GBM cells by down-regulation of farnesyl pyrophosphate…[Read more]

  • This study was planned to continue our previous study to assess effect of combination therapy bone marrow stromal cells (BMSCs) with exercise (EX) and triiodothyronine (T3) on stroke-induced astrogliosis in mice. Stroke subjected-mice were divided into five monotherapy groups including sham, control, BMSCs, EX and T3; and three combination therapy…[Read more]

  • Womble Healy posted an update 8 months ago

    These findings provide novel evidence that RGCs exhibit reduced light-dependent adaptation and increased excitability when IOP is elevated to low but not high levels. These results may reveal functional changes that occur early in glaucoma, which can potentially be used to identify patients with glaucoma at earlier stages when intervention is most…[Read more]

  • Hayes Burnett posted an update 8 months ago

    omplex examination of UC patients. Further clinical studies are necessary for assessment of the efficiency of anti-Blastocystis therapy in UC patients.

    Diagnosis of Blastocystis sp. should be introduced in the complex examination of UC patients. Further clinical studies are necessary for assessment of the efficiency of anti-Blastocystis therapy…[Read more]

  • Lykke Degn posted an update 8 months ago

    45% (5 in 11 isolates), while combinations of colistin with imipenem or ceftolozane and tazobactam displayed 36.36% (4 of 11 isolates) and 63.64% (7 of 11 isolates) synergism. In addition, combinations of colistin with levofloxacin was synergistic against 90.91% (10 of 11 isolates). The results revealed that combinations of colistin with other…[Read more]

  • Josephsen Estes posted an update 8 months ago

    Platelet-rich plasma (PRP) has potential uses for patients with spinal cord injuries (SCI). However, no study has quantified the cellular and growth factor (GF) content of PRP in this population. This study aimed to analyze 1) PRP content of SCI subjects and 2) the effect of high intensity interval exercise (HIIE) on their PRP.

    10 SCI…[Read more]

  • Emerson Slaughter posted an update 8 months ago

    Evidence to support this includes the significant differences between samples using PERMANOVA (p less then 0.001), the clear separation in ordination space of samples clustered by sampling method, the significantly higher richness in the surface samples (p less then 0.001), and the considerable variation in relative abundances of various taxa and…[Read more]

  • 8). No statistically significant differences were recorded for tumor relapse rate, cancer-specific and other cause mortality. No positive surgical margins were recorded in both groups. Daytime and nighttime continence recovery were 89.4% vs 87.1% (p = 1.0) and 63.8% vs 51.6% (p = 1.0) for ICNB vs ECNB. Potency recovery was 59.1% vs 54.3% (p = 0.…[Read more]

  • Mccall Salinas posted an update 8 months ago

    In natural habitats, plants have developed sophisticated regulatory mechanisms to optimize the photosynthetic electron transfer rate at the maximum efficiency and cope with the changing environments. Maintaining proper P700 oxidation at photosystem I (PSI) is the common denominator for most regulatory processes of photosynthetic electron…[Read more]

  • The contribution of residual Se to total Se in topsoil was decisive, and the content of other species of selenium changed slightly. The Se speciation that was residual in soil is difficult for plants to utilize, which is consistent with previous studies on seleniferous soils caused by zinc smelting. These results indicated that the main reason for…[Read more]

  • Lindholm Barrera posted an update 8 months ago

    Objective To understand the epidemiology and burden of severe coronavirus disease 2019 (covid-19) during the first epidemic wave on the west coast of the United States. Design Prospective cohort study. Setting Kaiser Permanente integrated healthcare delivery systems serving populations in northern California, southern California, and Washington…[Read more]

  • Lake Krogh posted an update 8 months ago

    6% (2/30) of apparently de novo cases.

    The search for parental somatic mosaicism should be routinely implemented in de novo cases of MFS, to offer appropriate genetic and reproductive counselling as well as to reveal masked, isolated clinical signs of MFS in progenitors that may require specific follow-up.

    The search for parental…[Read more]

  • Reynolds Haugaard posted an update 8 months ago

    Further studies, are needed to investigate effects of healthy lifestyle changes to improve HRQoL in lymphoma survivors. Research in understanding association of lifestyle factors may guide future support for lymphoma cancer survivors.

    MVPA was associated with higher HRQoL in lymphoma survivors regardless of BMI. Further studies, are needed to…[Read more]

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