• At the equatorial zone and anterior central zone of lens, AR expression and TUNEL-positive apoptotic LECs were significantly increased in the DM group compared with the control group, however, they were significantly decreased in the DM + NGF group. In conclusion, topical NGF could delay the progression of diabetic cataracts by attenuating polyol…[Read more]

  • French Guiana is an overseas territory of France with marked specificities in terms of populations, socioeconomic factors, risk factors, and an access to care. In this context, the objective of the present study was to describe the epidemiology of acute coronary syndromes in French Guiana and to make comparisons with mainland France and…[Read more]

  • The severe-pain incidence (NRS > 6, or CPOT > 5) was 5.9% (n = 7). Our incidence of overtreatment was 1.7%. The demographic data and ICU complication-rates of patients with adequate and inadequate pain treatment were similar.

    Pain assessment tools in critically ill patients should be developed and validated to the language of the tool…[Read more]

  • Objective To understand the epidemiology and burden of severe coronavirus disease 2019 (covid-19) during the first epidemic wave on the west coast of the United States. Design Prospective cohort study. Setting Kaiser Permanente integrated healthcare delivery systems serving populations in northern California, southern California, and Washington…[Read more]

  • The most frequent problem was a “lack of information to professionals” (25.06%), “problems as to the frequency and interval of doses” (22.90%), and “medication underdosing” (16.20%). Dose adjustment (31.50%) and clarifications (30.90%) were the most frequent pharmaceutical interventions. In the second round of Delphi, experts rated 77.77% of…[Read more]

  • 24).

    MSI prevalence in OGC was 12.4%, associated with antral localization and advanced age. Patients with MSI tumors had a lower cumulative incidence of recurrence after surgery. MSI phenotype was mainly associated with loss of MLH1 protein expression, MLH1 promotor hypermethylation and had no BRAFV600E mutation.

    MSI prevalence in OGC…[Read more]

  • BACKGROUND The prevalence of prehypertension in the world reaches 20-25% with a figure that is still high in Indonesia (48.4%). The role of health promotion is substantial in an effort of prevention and treatment of hypertension. AIM This study aims to determine the difference of effect between health promotion using media slides presentation and…[Read more]

  • the 1980s. These results are helpful for developing public health strategies to improve vitamin D status in lactating mothers and infants.Photodynamic therapy (PDT) is an innovative treatment of malignant or diseased tissues. The effectiveness of PDT depends on light dosimetry, oxygen availability, and properties of the photosensitizer (PS).…[Read more]

  • Ochoa Kay posted an update 9 months, 2 weeks ago

    Multiple logistic regression or Cox proportional hazard ratios were used to document risk. Generally, tramadol users had fewer adverse event risks compared to other opioid users but higher risks than nonusers. New users of tramadol or other opioids had higher risks than continuing users. Tramadol use was associated with increased risk of multiple…[Read more]

  • 1%) patients underwent TD ligation. Five patients (16.7%) received TDE after lung surgery and five patients (27.7%) after esophageal surgery. Also, in the second period, the hospital stay of patients who underwent lung cancer surgery was shorter than the first period (12.6 ± 4.6 days vs. 16.3 ± 9.7 days; p = 0.026).

    TDE is an effective met…[Read more]

  • RESULTS From a total of 630 patients submitted to SBCE for suspected SBB, 129 with angioectasias were included; 59.7% were female, with a median age of 72 (19-91) years old and a mean follow-up of 44.0 ± 31.9 months. In 32.6% (n = 42) of the patients, at least one episode of rebleeding was documented. The presence of heart failure (OR 3.41; IC…[Read more]

  • process, which may also enhance early diagnosis and enable disease staging in sCJD.Purpose of review In this review, we will discuss treatment interventions targeting drivers of immune activation and chronic inflammation in PWH. Recent findings Potential treatment strategies to prevent the progression of comorbidities in PWH have been identified.…[Read more]

  • Duke Holt posted an update 9 months, 2 weeks ago

    is the engagement of academic and community stakeholders to design, pilot test and implement a training program addressing healthcare.

    Equipping clinicians with skills to mitigate implicit bias in clinical encounters is crucial to addressing persistent disparities in healthcare outcomes. Our novel, integrated approach may improve patient…[Read more]

  • Dehydroepiandrosterone (DHEA) is a popular dietary supplement that has anti-inflammatory, anti-oxidant and immune-regulating role; meanwhile, it also can effective in the protection of inflammation diseases such as inflammatory bowel disease (IBD), but the underlying mechanisms remain elusive. Here, we demonstrated that DHEA inhibits excessive…[Read more]

  • Including diverse participants in biomedical research is essential to reduce health disparities. We assessed the inclusion of Asians in original research studies conducted in North America and published from 2015-2016 in six high-impact generalist journals New England Journal of Medicine, Journal of the American Medical Association (JAMA), JAMA…[Read more]

  • Our results may promote the development of gradient membranes for molecular sieving.The novel extremophilic yeast Rhodotorula frigidialcoholis, formerly R. JG1b, was isolated from ice-cemented permafrost in University Valley (Antarctic), one of coldest and driest environments on Earth. Phenotypic and phylogenetic analyses classified R.…[Read more]

  • There was little evidence that the four grassland bird species avoided fledging during the high-risk period and Savannah Sparrow fledged at higher rates during that period. All four species had hours during the low-risk period where they fledged at higher rates, but only Grasshopper Sparrow fledged preferentially during that period. Bobolink and…[Read more]

  • Quality review was moderate with 3/7 to 5/7 quality criteria met. HIIE acutely lowered exercise MCAv compared to moderate intensity. HIIE decreased dCA phase following acute and chronic exercise compared to rest. HIIE acutely increased de/oxygenated hemoglobin compared to rest. HIIE acutely decreased cerebrovascular reactivity to higher CO2…[Read more]

  • The incidence of unintentional intraneural injection while performing peripheral nerve block has been estimated to be 15% under real-time ultrasound guidance. Injection pressure increase may detect an intraneural injection. Real-time injection pressure changes throughout an entire nerve block procedure in relationship with needle tip location have…[Read more]

  • Objective Network analysis in psychology has ushered in a potentially revolutionary way of analyzing clinical data. One novel methodology is in the construction of temporal networks, models that examine directionality between symptoms over time. This paper provides context for how these models are applied to clinically-relevant longitudinal data.…[Read more]

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