• Ottosen Crawford posted an update 8 months ago

    Spermidine is a natural polyamine, central to cellular homeostasis and growth, that promotes macroautophagy/autophagy. The polyamine pathway is highly conserved from bacteria to mammals and spermidine (prominently found in some kinds of aged cheese, wheat germs, nuts, soybeans, and fermented products thereof, among others) is an intrinsic part of…[Read more]

  • Geisler Lowry posted an update 8 months ago

    284 , together with increased neutrophil count (OR = 1.029 ) and WHO disease severity class (OR = 7.632 ). AUROC analysis showed a good discriminative performance of MR-proADM (AUROC 0.849 ; p  less then  0.0001). The optimal value of MR-proADM to discriminate combined event of death or IOT is 0.895 nmol/l, with a sensitivity of 0.857 and a speci…[Read more]

  • Diabetes mellitus (DM) is chronic and metabolic disorder, which is mainly attributed by hyperglycemia. Vanadium salts and their oxo-complexes have been shown to possess insulin-mimetic and anti-diabetic activities in animal models and diabetic patients. The main goal of this study was to investigate the protective effect of oxovanadium(IV) complex…[Read more]

  • Dalgaard Malling posted an update 8 months ago

    Both of these effects tend to reduce the saturation of the structural color, which limits the use of these materials in applications. We show that while the single-scattering model cannot reproduce the observed saturations, it can be used as a design tool to reduce the amount of multiple scattering and increase the color saturation of materials,…[Read more]

  • Thestrup Fagan posted an update 8 months ago

    Biopolymers are rapidly gaining attention as sustainable precursors for lightweight porous materials for energy-saving, pharmaceutical, catalysis, and environmental remediation applications. Chitosan is an abundant biopolymer derived from food waste with attractive properties, particularly its high biocompatibility and easy chemical…[Read more]

  • Abildgaard Bowles posted an update 8 months ago

    Over the past two decades, Acinetobacter baumannii has emerged as a leading cause of nosocomial infections worldwide. Of particular concern are panresistant strains, leading the World Health Organization (WHO) to designate carbapenem-resistant A. baumannii as a priority 1 (critical) pathogen for research and development of new antibiotics. A key…[Read more]

  • Tyson Tarp posted an update 8 months ago

    Subsequent to their purification we have further explored their incorporation into membrane scaffolding protein nanodiscs, which will enable future structural studies. Pyroptosis, a form of programmed cell death, has garnered increasing attentions as it relates to innate immunity and diseases. The discovery of caspase-1/3/4/5/8/11 function in…[Read more]

  • Bauer McKee posted an update 8 months ago

    The aberrant protein-protein interaction between calmodulin and mutant huntingtin protein in Huntington’s disease patients has been found to contribute to Huntington’s disease progression. A high-throughput screen for small molecules capable of disrupting this interaction revealed a sultam series as potent small-molecule disruptors.…[Read more]

  • Dalgaard Brewer posted an update 8 months ago

    Invited for the cover of this issue is Liqiang Mai and co-workers at Wuhan University of Technology. The image depicts Ni3 Fe alloy nanoparticles encapsulated in N-doped graphene as an efficient bifunctional oxygen electrocatalyst toward rechargeable Zn-air batteries, which is expected to drive the electric vehicle. Read the full text of the…[Read more]

  • Sloth Galbraith posted an update 8 months ago

    elated with each other. PCR measurement of HIV reservoir size showed that ADCC activity was higher in ECs and VCs with a reservoir size below the limit of detection compared to those having a measurable HIV reservoir size.Immunoregulation in the testis is characterized by a balance between immuno-suppression (or immune privilege) and the ability…[Read more]

  • Svane Brock posted an update 8 months ago

    Medical treatment serves as the primary intervention, necessitating surgical expertise as the condition advances to a more complex stage. Surgical removal of maggots was required in a two-and-a-half-year-old girl with aural myiasis, a rare occurrence, which caused tympanic membrane perforation.

    Within ENT practice, foreign objects found…[Read more]

  • 52 J g-1 K-1 for a wet sludge to 1.71 W m-1 K-1 and 0.78 J g-1 K-1 for a dry sludge respectively. The relationships between thermo-physical / mechanical properties and the water content / temperature of the sludge are established to be introduced in the created numerical drying model.Objective Management of patients after failed epilepsy surgery…[Read more]

  • Carlson Goodman posted an update 8 months ago

    A genetic basis of congenital isolated hypogonadotropic hypogonadism (CHH) can be defined in almost 50% of cases, albeit not necessarily the complete genetic basis. Next-generation sequencing (NGS) techniques have led to the discovery of a great number of loci, each of which has illuminated our understanding of human gonadotropin-releasing hormone…[Read more]

  • Duckworth Dehn posted an update 8 months ago

    Individuals with obesity are recommended to practice physical activity with reduced weight bearing, such as water-based exercises. However, the magnitude of the vertical ground reaction force (Fz) during these exercises is unknown in this population. This study aimed to verify the magnitude of peak Fz (Fzpeak) in women with obesity during…[Read more]

  • Martinez Dunlap posted an update 8 months ago

    Synthesis of other compounds – parent 1,4-DHPs 1 and 2, and 4-Py-1,4-DHPs 3-5, their characterisation, estimation of cytotoxicity and self-assembling properties for all 4-Py-1,4-DHPs 3-6 are reported herein for the first time. Information provided in this data file can be used in medicinal chemistry by other scientists to estimate…[Read more]

  • Dogan Klint posted an update 8 months ago

    This misalignment within couples was pronounced during the initial session and decreased by the midtreatment session, reflecting progression toward treatment goals. Of the latent growth curve models, only client sustain talk during the midtreatment session predicted greater client drinking at the end of treatment. Results provide insight into the…[Read more]

  • Sosa Hatfield posted an update 8 months ago

    The purpose of this study is to evaluate the risk of medial tibial cortical perforation in unicompartmental knee arthroplasty (UKA) due to peg positions on the tibial tray of the Persona Partial Knee (PPK).

    Preoperative CT images of 60 patients and 60 osteoarthritic knees (30 male and 30 female patients) were used. A tibial multiplanar…[Read more]

  • Bunn Kragh posted an update 8 months ago

    Both in vitro and in vivo evaluations show that the presented nanotheranostic systems bearing good photostability and appreciable biosecurity perform well in fluorescence imaging-guided photodynamic cancer therapy. This study thus not only extends the application scopes of AIE nanomaterials but also offers useful insights into constructing…[Read more]

  • Shapiro Butler posted an update 8 months ago

    Deciphering gender differences in COVID-19 offers a window into the principles of immunity against SARS-CoV-2 infection and this information on ageing dependent gender disparity might contribute to our current understanding of COVID-19 infection and disease treatment.We propose a model-based deep learning architecture for the reconstruction of…[Read more]

  • Archer Bowers posted an update 8 months ago

    Numerous immunomodulatory effects of resveratrol suggest it may be useful in combination with other cancer therapies including immunotherapy for effective cancer management.The prevalence of hypovitaminosis D has risen in developed countries over the past few years in association with lifestyle changes and an increase in unhealthy habits. Vitamin…[Read more]

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