-
Sinclair Groth posted an update 8 months ago
An 81-year-old immunocompetent patient with bronchiectasis and refractory Mycobacterium abscessus lung disease was treated for 6 months with a three-phage cocktail active against the strain. In this case study of phage to lower infectious burden, intravenous administration was safe and reduced the M. abscessus sputum load tenfold within one month.…[Read more]
-
Hancock Holdt posted an update 8 months ago
Eating disorders represent one of the most common psychiatric disorders in adolescents with type 1 diabetes mellitus (T1DM), with a prevalence twice as high as in individuals without diabetes. The increased risk for acute and long-term medical complications and a three-fold mortality rate with this dual condition makes it extremely important to…[Read more]
-
Reynolds Goff posted an update 8 months ago
When psychosis emerges in young people there is a risk of poorer outcomes, and access to evidence-based treatments is paramount. The current evidence base is limited. Antipsychotic medications show only a small benefit over placebo, but young people experience more side effects than adults. There is sparse evidence for psychological intervention.…[Read more]
-
Armstrong McGee posted an update 8 months ago
should still be offered, based on participant preference. Customising e-consenting platforms may improve accessibility for individuals with specific needs, and increase engagement with study information. Research teams must offer prospective participants opportunities to discuss study information in real-time.
E-consent may facilitate…[Read more]
-
Staal McClellan posted an update 8 months ago
Long-term methotrexate (MTX) treatment is known to cause MTX-associated lymphoproliferative disorder (MTX-LPD). A 58-year-old woman with psoriasis vulgaris and pityriasis rubra pilaris was treated with a combination of MTX and ustekinumab for 4 months when she developed generalized lymphadenopathy. The initial histopathological analysis indicated…[Read more]
-
Sloan Shapiro posted an update 8 months ago
Results Baseline BMI was 47.9 ± 7.1 kg/m2 and reduced by 5% and 30% post-diet and post-surgery, respectively. BP decreased only post-diet, without pulse pressure change. However, ncPWV, 6.27 ± 1.35 m/s at baseline, was significantly reduced by 10% and 23% post-diet and post-surgery, respectively, also adjusted for BP changes. The E/A ratio rose f…[Read more]
-
Gonzales McConnell posted an update 8 months ago
The molecular target and mechanism by which d-limonene induces LC3 lipidation and autophagosome formation remain elusive. Here, we report that this monoterpene rapidly enhances Ca2+ levels in SH-SY5Y cells; yet this effect does not lead to calpain- or caspase-mediated proteolysis of α-spectrin, nor calpain activity is required for the established…[Read more]
-
Lanier Daniels posted an update 8 months ago
Management of gestational diabetes (GDM) is currently changing toward a more personalized approach. There is a growing number of GDM patients requiring only a single dose of basal insulin at night to achieve glucose control. Well-known risk factors like obesity, parity and family history have been associated with GDM treatment requirements. Sleep…[Read more]
-
Pettersson Mejer posted an update 8 months ago
The exposure to PFAAs in peregrine falcons is likely mediated by dietary factors such as foraging location (δ13C and δ34S) and trophic position (δ15N) given the associations observed in eggs and nestling plasma, respectively. Moreover, significant relationships were observed for circulating ΣPFCAs and region (rural/urban), and nestling body con…[Read more]
-
Sommer Jepsen posted an update 8 months ago
The most common variant of fullerene core functionalization is the cycloaddition process. Of these, reactions leading to methanofullerenes are the most promising. They are synthesized in two main reactions nucleophilic cyclopropanation according to the Bingel method and thermal addition of diazo compounds. This present review summarizes the…[Read more]
-
Ortega Rutledge posted an update 8 months ago
Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) is a rare primary headache syndrome. Emricasan However, some cases of secondary SUNCT are attributed to underlying diseases such as demyelination. We herein report a case of SUNCT with progression to neuromyelitis optica spectrum disorder (NMOSD). A…[Read more]
-
Abbott Sharma posted an update 8 months ago
BACKGROUND Effective communication is at the heart of good medical practice but rates of error, patient complaints, and poor clinician job satisfaction are suggestive of room for improvement in this component of medical practice and education. METHODS We conducted semi-structured interviews with experienced clinicians (n = 19) and medical stu…[Read more]
-
Anthony Watkins posted an update 8 months ago
The extent of surgical intervention, also with regard to simultaneous neck dissection, depends on tumor stage. In the case of oropharyngeal carcinomas, there will be an increasing distinction between human papillomavirus (HPV)-negative and HPV-positive tumors in the future; however, the therapeutic strategy is currently identical. Upcoming…[Read more]
-
Leblanc Feddersen posted an update 8 months ago
This study aimed to assess and compare XP-Endo Finisher (XP) cleaning efficiency with respect to the amount of remaining debris and smear layer versus Max-I-Probe needle (CI), EndoActivator device (EA), and combination of XP-Endo Finisher file with EndoActivator device (XP+EA) in oval root canals.
This
study was performed on 36 ext…[Read more]
-
Panduro Risager posted an update 8 months ago
RESULTS The first part of the study showed that RTx patients presented significantly lower serum content of all the examined PUFA, in comparison to the CKD-ND group and controls. For instance, EPA in RTx equaled 0.65 ± 0.32%, in CKD-ND 0.82 ± 0.43%, and in controls 1.06 ± 0.68% (P = .005). No significant correlations were found between serum PU…[Read more]
-
Coffey Elliott posted an update 8 months ago
To synthetize the evidence regarding the effect of constant flow insufflation of oxygen (CFIO) on the rate of return of spontaneous circulation (ROSC) and other clinical outcomes during cardiac arrest (CA).
A systematic review was performed using four databases (PROSPERO CRD42020071960). Studies reporting on adult CA patients or on animal…[Read more]
-
Stanley Daniels posted an update 8 months ago
ents consulting general practitioners have a high number of self-reported symptoms.The most frequent symptoms are tiredness, lower back pain, neck pain, headache, shoulder pain, and sleep problems.Patients diagnosed with asthenia and depression/anxiety report the highest number of symptoms.Selected diagnoses show similar patterns in symptom…[Read more]
-
Stephens Dotson posted an update 8 months ago
These results reinforce the notion that tDCS effects are characterized by an activity reduction and might be more noticeable in compromised systems. Importantly, the data provide novel evidence that cognitive trajectories predict tDCS effects in older adults.
Although statistical associations between tooth loss and cognitive decline have been…[Read more]
-
Leonard Dunlap posted an update 8 months ago
Velocity is a decreasing function of the Casson fluid parameter. M4205 Temperature is enhanced for higher radiation during reverse hold for concentration against the Marangoni number. The Bejan number and entropy generation have similar effects for Casson fluid and radiation parameters. For a higher estimation of the Brinkman number, the entropy…[Read more]
-
Wallace Kamp posted an update 8 months ago
Early the diagnosis, better the prognosis.
The role of two polymorphisms rs1800591 and rs3816873 of the microsomal triglyceride transfer protein (MTTP) gene in the development of nonalcoholic fatty liver disease (NAFLD) remains controversial. A meta-analysis was conducted to determine the correlation between these MTTP polymorphisms and…[Read more]
- Load More