• Paaske Gallegos posted an update 8 months ago

    In this nested case-control study, we investigated if antiviral treatment given prior to onset of Alzheimer’s disease (AD) could influence incident AD.

    From a large population-based cohort study in northern Sweden, 262 individuals that later developed AD were compared to a non-AD matched control group with respect to prescriptions of…[Read more]

  • Stafford Guerrero posted an update 8 months ago

    Neurobiological heterogeneity in schizophrenia is poorly understood and confounds current analyses. We investigated neuroanatomical subtypes in a multi-institutional multi-ethnic cohort, using novel semi-supervised machine learning methods designed to discover patterns associated with disease rather than normal anatomical variation. Structural MRI…[Read more]

  • Ladefoged Hanson posted an update 8 months ago

    787 to 39.8 ng/mL (median 5.87 ng/mL), 0 to 2.13 ng/mL (0.347 ng/mL), and 1.98 to 82.8 ng/mL (16.6 ng/mL), respectively. Such low concentrations of paracetamol were deemed irrelevant to therapeutic effect. Based on statistical analysis, the preliminary Japanese residue limits of unhydrolyzed and hydrolyzed paracetamol were determined to be 70.5…[Read more]

  • Espensen Zacho posted an update 8 months ago

    The optimal timing of anticoagulation after stroke in patients with atrial fibrillation (AF) is unknown. We aimed to objectively assess the rate of radiological hemorrhagic transformation (HT) associated with early anticoagulation.

    A prospective, open label study (NCT04435418) of patients with AF treated with apixaban within 14days of…[Read more]

  • Parrish Aaen posted an update 8 months ago

    interchangeably for the same patient on different test sessions.PRéCIS In a case-control study, skin pigmentation was not statistically significantly different when comparing glaucoma patients to those without glaucoma.

    Darker skin color has been implicated as a risk factor for glaucoma based on previous studies’ subjective assessments of…[Read more]

  • Wu Heller posted an update 8 months ago

    The implementation of large-scale containment measures by governments to contain the spread of the COVID-19 virus has resulted in large impacts to the global economy. Here, we derive a new high-frequency indicator of economic activity using empirical vessel tracking data, and use it to estimate the global maritime trade losses during the first…[Read more]

  • Goldberg Skaaning posted an update 8 months ago

    ulation.

    Iguratimod combined with methotrexate may be considered a promising alternative for treating RA. GSK8612 Key Points • Iguratimod combination therapy produced better results in all the efficacy outcomes than methotrexate monotherapy. • Iguratimod combination therapy may be as safe as methotrexate monotherapy. • We recommend future clini…[Read more]

  • Compton Knox posted an update 8 months ago

    Research on direct targets of traditional Chinese medicine (TCM) is the key to study the mechanism and material basis of it, but there is still no effective methods at present. We took Compound Danshen dropping pills (CDDP) as a study case to establish a strategy to identify significant direct targets of TCM. As a result, thirty potential active…[Read more]

  • Lake Oneal posted an update 8 months ago

    The overexpression of LINC00511 significantly elevated the viability and EdU-positive rate in H2O2-treated cardiomyocytes. LINC00511 could bind to miRNA-515-5p. Meanwhile, there was a negative correlation between the levels of LINC00511 and miRNA-515-5p. In addition, the overexpression of miRNA-515-5p reversed the promoting effect of LINC00511 on…[Read more]

  • Farley Parks posted an update 8 months ago

    The semitendinosus tendon and its regeneration can be visualized well using ultrasonography. After semitendinosus harvesting, the flexion strength will be decreased as compared to the normal knee. The flexion strength in patients who have a regenerated tendon will be higher as compared to those who have no regeneration.Dental implants require…[Read more]

  • Pennington Booth posted an update 8 months ago

    41, p < 0.001). Weight gain ≥2kg on postoperative day 1 was also a risk factor (OR 1.76, p < 0.001).

    A high BMI, a pancreaticojejunostomy and postoperative weight gain were risk factors for developing POPF. Diabetes or preoperative biliary drainage was protective.

    A high BMI, a pancreaticojejunostomy and postoperative weight gain were…[Read more]

  • Weeks Daniels posted an update 8 months ago

    Infections caused by multidrug-resistant bacteria have emerged in recent decades, leading to escalating interest in host defense peptides (HDPs) to reverse this dangerous trend. Inspired by the modular design in bioengineering, herein we report a new class of small amphiphilic scorpionlike peptidomimetics based on this strategy. These HDP mimics…[Read more]

  • Hvass Sosa posted an update 8 months ago

    Seem ingestion by way of a metasurface including difficult areas inside a soft medium.

    The proposed sensor was successfully applied in HBV DNA detection in sera from patients without any amplification step (e.g., PCR) required, thus simplifying the operation further. Additionally, the results obtained from this present device are in accordance…[Read more]

  • Kendall Matthiesen posted an update 8 months ago

    ry conditions consistent with biocontainment level 2. This assay offers promise also in evaluating immunogenicity of spike glycoprotein-based candidate vaccines in the near future.

    Quebec is one of the Canadian provinces with the highest rates of cancer incidence and prevalence. A study by the Rossy Cancer Network (RCN) of McGill university…[Read more]

  • Silverman Callahan posted an update 8 months ago

    crowding.Chagas disease remains a serious problem for public health due to the high disease burden together with its global spreading patterns. However, current treatment and vector control are highly challenged by drug and insecticide resistance. Chemotherapy and vector control have been proved to be effective attempts to minimize the disease…[Read more]

  • Drew McCartney posted an update 8 months ago

    23 per cent (15/17) gall bladder tumour samples as compared to non-tumour tissues (39.13%, 9/23). Real-time qRT-PCR analysis revealed a significant downregulation of desmin expression in GBC as compared to ANT tissue. This was further confirmed by western blot, showing reduced expression of desmin protein in GBC, as compared to non-tumour tissue.…[Read more]

  • Huff Dunn posted an update 8 months ago

    Conversely, for patients with biallelic CEBPA or DNMT3A mutations, only the MFC method was recommended due to the poor prognostic discriminability in tracking mutant transcripts. In conclusion, this study demonstrated that the MFC MRD after two consolidation cycles independently predicted clinical outcomes, and the integration of MFC and molecular…[Read more]

  • Odom Tan posted an update 8 months ago

    Sleep deprivation (SD) is a common issue in today’s society. Sleep is essential for proper cognitive functions, including learning and memory. Furthermore, sleep disorders can alter pain information processing. Meanwhile, hippocampal nicotinic receptors have a role in modulating pain and memory. The goal of this study is to investigate the effect…[Read more]

  • Aycock Medlin posted an update 8 months ago

    38, R2 0.9946).

    These results suggest that the combination of NIR spectroscopy and chemometric method provides a fast, simple and reliable method for detecting the adulteration of DHS.

    The method of classification allowed to identifing among authentic and adulterated DHS samples. Comparison of six different techniques for spectra…[Read more]

  • Richter Fields posted an update 8 months ago

    02; 95% CI = 1.21-3.38). After stratification by menopausal status and rs297325 genotypes, the OR; 95% CI was 0.62; 0.38 to 0.99 in premenopausal women with the TC + CC genotype and 1.24; 0.82 to 1.88 in menopausal women with the TC + CC genotype. CONCLUSION SOX6 rs297325 was not significantly associated with osteoporosis but might have modula…[Read more]

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