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Stevens Mcclain posted an update 1 year ago
The present study aimed to identify genes associated with gastric cancer survival and improve risk stratification for patients with gastric cancer. Transcriptomic and clinicopathological data from 443 gastric cancer samples were retrieved from The Cancer Genome Atlas database. The DESeq R package was applied to screen for differentially expressed…[Read more]
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Nash Bruun posted an update 1 year ago
Heterozygous mutations of the GBA1 gene, encoding for lysosomal enzyme glucocerebrosidase (GCase), occur in a considerable percentage of all patients with sporadic Parkinson’s disease (PD), varying between 8% and 12% across the world. Genome wide association studies have confirmed the strong correlation between PD and GBA1 mutations, pointing to…[Read more]
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Castaneda Castro posted an update 1 year ago
The Global Pertussis Initiative is an expert scientific forum that publishes consensus recommendations concerning pertussis for many regions of the world. Here, we give recommendations for the primary vaccination of infants in those countries where whole-cell pertussis (wP)- and acellular pertussis (aP)-containing combination vaccines are used in…[Read more]
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McHugh Damsgaard posted an update 1 year ago
Objective measurement of speech has shown promising results to monitor disease state in multiple sclerosis. In this study, we characterize the relationship between disease severity and speech metrics through perceptual (listener based) and objective acoustic analysis. We further look at deviations of acoustic metrics in people with no perceivable…[Read more]
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Aagaard Levesque posted an update 1 year ago
There is a pressing need to marry biology with therapeutics, especially with the burgeoning treatment landscape in FL, to aid in optimising patient selection and guiding the ‘right drug to the right patient’.TDP-43 is the major component of pathological inclusions in most ALS patients and in up to 50% of patients with frontotemporal dementia…[Read more]
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Egan Hewitt posted an update 1 year ago
Knocking out catalase results in P-AscH- radio-sensitization in PDACs. In a phase I trial where P-AscH- was included as an adjuvant to the standard of care, short-term survivors had higher catalase levels in tumor tissue, compared to long-term survivors. These data suggest that P-AscH- radio-sensitizes PDACs through increased peroxide flux.…[Read more]
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Lindholm Mckay posted an update 1 year ago
Multiple sclerosis (MS) is a chronic, autoimmune, neurodegenerative disease of the central nervous system (CNS) that yields to neuronal axon damage, demyelization, and paralysis. Although several drugs were designed for the treatment of MS, with some of them being approved in the last few decades, the complete remission and the treatment of…[Read more]
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Tillman Rosendahl posted an update 1 year ago
5%) and lymph node metastases (33.3%). Among 33 patients with intrahepatic tumors and MVTT, 18 had differential responses in each site, including 13 with a better response in MVTT versus intrahepatic lesions. Among 18 patients whose MVTT achieved a radiographic CR or PR, six underwent surgical resection 4/6 achieved a pathological CR in MVTT and…[Read more]
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Sweet Hatfield posted an update 1 year ago
This substantial growth as a feeding larva, ca. 80 times in volume, is comparable or even greater than those of confamilial species in the hydrothermal-vent and methane-seep environments in the Northwest Pacific and Atlantic Oceans. Large pigmented eyes in newly settled juveniles are another common feature in this and other phenacolepadids…[Read more]
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Hermann Reimer posted an update 1 year ago
ms that can be activated by 808 nm light excitation sources for application in photodynamic therapy. Our nanoplatforms remain photoactive after internalization by living cells, allowing for 808 nm-activated ROS generation. The versatility of our polymer-stabilization strategy promises a straightforward access to other derivatizations (for…[Read more]
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Mccall Weber posted an update 1 year ago
With the growth of the global population and the increasing frequency of natural disasters, crop yields must be steadily increased to enhance human adaptability to risks. Pre-harvest sprouting (PHS), a term mainly used to describe the phenomenon in which grains germinate on the mother plant directly before harvest, is a serious global problem for…[Read more]
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Mccall Kejser posted an update 1 year ago
Class D β-lactamases have risen to notoriety due to their wide spread in bacterial pathogens, propensity to inactivate clinically important β-lactam antibiotics, and ability to withstand inhibition by the majority of classical β-lactamase inhibitors. Understanding the catalytic mechanism of these enzymes is thus vitally important for the de…[Read more]
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Yde Milne posted an update 1 year ago
The description of this new species is given below.Within Dalyelliidae Graff, 1905, Gieysztoria Ruebush Hayes, 1939 is the most widely distributed and speciose genus, members of which live in marine, brackish, or freshwater habitats (Van Steenkiste et al., 2012). Gieysztoria is composed by ~97 free-living species (Tyler et al. 2016), and species…[Read more]
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Lundsgaard Steenberg posted an update 1 year ago
Pulmonary arterial hypertension (PAH) is a rare, chronic disease of the pulmonary vasculature that is associated with poor outcomes. Its pathogenesis is multifactorial and includes micro-RNA (miRNA) deregulation. The understanding of the role of miRNAs in PAH is expanding quickly, and it is increasingly difficult to identify which miRNAs have the…[Read more]
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Mead Brandt posted an update 1 year ago
In conclusion, there may be an increased risk of injury withthe non-dominant leg due to changes in kinematic parameters caused by fatigue and unpredictable CoD manoeuvres.Slowed processing speed is part of normal aging but also a symptom of many diseases, including dementia. A Quick Test of Cognitive Speed (AQT) consists of three conditions color…[Read more]
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Franklin Parks posted an update 1 year ago
In pregnancies complicated by fetal congenital cardiac anomaly, mothers of infants with planned future surgery or neonatal death are at significant risk for postpartum depression.
To determine the relationship between maximum vasoactive-inotropic (VIS
) and mortality in extremely premature (<29 weeks completed gestation), extremely low…[Read more]
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Covington Bryan posted an update 1 year ago
Objective To characterize earlier damage pattern of white matter (WM) microstructure in cerebral small vessel disease (CSVD) and its relationship with cognitive domain dysfunction. Methods A total of 144 CSVD patients and 100 healthy controls who underwent neuropsychological measurements and diffusion tensor imaging (DTI) examination were…[Read more]
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Rouse Hardison posted an update 1 year ago
High amounts of toxic textile dyes are released into the environment due to coloring and wastewaters treatment processes’ inefficiency. To remove dyes from the environment and wastewaters, researchers focused on applying immobilized enzymes due to mild reaction conditions and enzyme nontoxicity. Laccases are oxidases with wide substrate…[Read more]
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Torres Quinn posted an update 1 year ago
Induction of apoptosis was not a significant event for any of the genetically distinct local isolates of BoHV-4 and there was not an evident relationship between the variability of both genes with the apoptotic effect of the phylogenetically distinct strains. Staphylococcus aureus is one of the major bacterial mastitis pathogens with significant…[Read more]
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Kara Chu posted an update 1 year ago
We resolve the contradiction between two recent experimental studies of the possible catalytic effect of water vapor on CH 3 OH + OH reaction and we extend the rate constant evaluation down to 200 K. The rate constants of the CH 3 OH + OH reaction catalyzed by a water molecule are computed as functions of temperature and relative humidity using…[Read more]
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