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Lim Joensen posted an update 8 months, 1 week ago
Pembrolizumab, a PD1 immune checkpoint inhibitor (ICI), was recently reported to be very effective in patients with microsatellite instable/deficient mismatch repair metastatic colorectal cancer (MSI/dMMR mCRC), unlike patients with microsatellite stable/proficient MMR (MSS/pMMR) mCRC, in whom ICIs are generally ineffective. However, about 15% of…[Read more]
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Berthelsen Hammer posted an update 8 months, 1 week ago
Objective The objective of this study was to perform a population-based estimation of the preterm birth (PTB) rate in regions surrounding Lilongwe, Malawi. Study Design We partnered with obstetrician specialists, community health workers, local midwives, and clinicians in a 50 km region surrounding Lilongwe, Malawi, to perform a popul…[Read more]
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Price Paul posted an update 8 months, 1 week ago
Moyamoya disease and syndrome are progressive steno-occlusive cerebrovascular diseases that manifest clinically with ischemic episodes. There is evidence for the use of electroencephalography (EEG) in preoperative and long-term postoperative evaluation of these patients, as well as in the intraoperative period to monitor for changes correlated…[Read more]
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Harris Koenig posted an update 8 months, 1 week ago
Integrated omics analysis identified key miRNA-mRNA modules (particularly, novel pairs of miRNAs and transcription factors) with antagonistic regulatory patterns subject to different stresses. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) enrichment analysis revealed significant roles in plant growth and stress adaptation.…[Read more]
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Dinesen Pena posted an update 8 months, 1 week ago
An exceptional point occurring in a tailor-made lossy optical system has been recently found to alter optical properties in counter-intuitive ways. In the context of tunable plasmonic devices, exceptional points can be useful as a driving mechanism to enhance tunability. Here, we experimentally demonstrate how a plasmonic exceptional point can be…[Read more]
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Osborn Fulton posted an update 8 months, 1 week ago
g. 20.3 μg L-1 of 4-chloro-3-nitrobenzotrifluoride in 2017) as well as at large distance (e.g. 22.4 μg L-1 of 3N4CBTF and 12.5 μg L-1 of 4-chlorobenzotrifluoride in 2018). Selleck Pimicotinib The results of BTFs monitoring campaigns carried out in 2008-2009 and 2017-2018 are compared and related to the historical data to assess the overall oc…[Read more]
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Lamb Charles posted an update 8 months, 1 week ago
Simvastatin (SIM) has been documented to induce the osteogenic differentiation of periodontal ligament stem cells (PDLSCs). To establish an efficient release system for periodontal regeneration, a polycaprolactone (PCL) membrane scaffold containing SIM was electrospun and evaluated. The obtained PCL-SIM membrane scaffold showed sustained release…[Read more]
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Hill Watson posted an update 8 months, 1 week ago
Background Schistosomiasis is a parasitic disease that resides in the vascular system of vertebrates, causing a chronic, debilitating disease that affects more than 200 million people and 800,000 deaths per year in over 70 countries. This parasite causes liver dysfunction and disorders normal hematological and biochemical profiles in addition to…[Read more]
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Cantu Roberson posted an update 8 months, 1 week ago
We developed a real-time sleep stage classification system with a convolutional neural network using only a one-channel electro-encephalogram source from mice and universally available features in any time-series data raw signal, spectrum, and zeitgeber time. To accommodate historical information from each subject, we included a long short-term…[Read more]
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Woodruff Gravgaard posted an update 8 months, 1 week ago
Meta-analyses indicated detrimental effects on some psychological dimensions from job loss and extended periods of unemployment. This study analyses three phenomena causes attributed to unemployment; processes for coping with unemployment; and the emotional impact of joblessness. Using an SEM approach, a model is created in which unemployment…[Read more]
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McGrath Coley posted an update 8 months, 1 week ago
The colon showed damage in the simple prismatic tissue and decreased crypt depth, and changes in microbiota and a decrease in the apparent fecal digestibility of crude protein were determined. Our results show that the adverse effects provoked by TBLF were partially reversed after 6 weeks of recovery post-treatment, suggesting that increasing the…[Read more]
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Owens Rasch posted an update 8 months, 1 week ago
Metabolomics, lipidomics, and the study of cellular metabolism are gaining increasing interest particularly in the field of immunology, since the activation and effector functions of immune cells are profoundly controlled by changes in cellular metabolic asset. Among the different techniques that can be used for the evaluation of cellular…[Read more]
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Mathiassen Herring posted an update 8 months, 1 week ago
DSBs proximal to telomeres rarely form COs, likely because of formation of unstable recombination intermediates that cannot be sustained as chiasmata until late prophase. Our work supports a model in which regulation of CO position early in meiotic prophase is required for proper designation of chromosome subdomains and normal chromosome…[Read more]
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Karstensen Bonde posted an update 8 months, 1 week ago
An additional small segment of the esophageal wall was excised. Histologically, the mediastinal surface of the sequestration tissue contained pancreatic tissue. Furthermore, esophageal and gastric tissue, cartilage tissue, and ciliated epithelium were confirmed. A definitive diagnosis of BPFM was made.
We postulated the rare case of a…[Read more]
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Love Gammelgaard posted an update 8 months, 1 week ago
Hip Resurfacing (HR), although reducing in popularity, is still used in the younger male population. Excellent medium-term results have been published; however, the use of metal on metal has reduced with increased awareness of adverse reactions to metal debris (ARMD). ARMD has been shown to often be clinically “silent” following large Head MoM…[Read more]
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Durham Todd posted an update 8 months, 1 week ago
This paper concludes with a proposal to establish an international collaboration among academics and HTA agencies in the region the REAL World Data In ASia for HEalth Technology Assessment in Reimbursement (REALISE) working group, which seeks to develop a non-binding guidance document on the use of RWD/RWE to inform HTA for decision making in…[Read more]
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Mcintyre Hewitt posted an update 8 months, 1 week ago
Aspergillus fumigatus is a pathogenic fungus infecting the respiratory system and responsible for a variety of life-threatening lung diseases. A fucose-binding lectin named FleA which has a controversial role in A. fumigatus pathogenesis was recently identified. New chemical probes with high affinity and enzymatic stability are needed to explore…[Read more]
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Egan Purcell posted an update 8 months, 1 week ago
This paper aims to investigate detailed mechanical interactions between the pulmonary haemodynamics and left heart function in pathophysiological situations (e.g. atrial fibrillation and acute mitral regurgitation). This is achieved by developing a complex computational framework for a coupled pulmonary circulation, left atrium and mitral valve…[Read more]
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Bloch Bock posted an update 8 months, 1 week ago
Using and combining eye-tracking and EEG frequency band power as process measures, in the current study we were interested in the mental processing demands during learning of text-picture combinations that either enabled or prohibited text-picture integration (TPI). In the mismatch condition, the textual and pictorial information being dissimilar,…[Read more]
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Fitch Burks posted an update 8 months, 1 week ago
People with atrial fibrillation (AF) have lower reported quality of life and increased risk of heart attack, death, and stroke. Lifestyle modifications can improve arrhythmia-free survival/symptom severity. Shared medical appointments (SMAs) have been effective at targeting lifestyle change in other chronic diseases and may be beneficial for…[Read more]
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