• We demonstrate how harmonic quasilocalized modes hybridize with other soft excitations, whereas NQEs properly represent soft spots without hybridization. We show that NQEs’ energies converge to the energies of the softest, nonhybridized harmonic quasilocalized modes, cementing their status as true representatives of soft spots in structural…[Read more]

  • Microbe-mediated mineralization is ubiquitous in nature, involving bacteria, fungi, viruses, and algae. These mineralization processes comprise calcification, silicification, and iron mineralization. The mechanisms for mineral formation include extracellular and intracellular biomineralization. The mineral precipitating capability of microbes is…[Read more]

  • 2 ± 14.7%, 26.9 ± 12.6%, and 15.3 ± 7.1%, respectively), and the average self-care score was 12.2 ± 3.5 (10-27) for all patients. Higher self-care score was significantly related to younger patients’ age and higher daily radiation exposure in nurses. CONCLUSION Individual exposure to radiation was well controlled. Nurses who care for pediatric…[Read more]

  • In the era of direct-acting antiviral therapies, hepatitis C positive organs offer a strategy to expand the donor pool. Heart failure patients with concomitant renal insufficiency benefit from combined heart/kidney transplant. In 2017, we began utilizing organs from hepatitis C donors for heart/kidney transplants.

    Characteristics and…[Read more]

  • Interestingly, the spheroid forming capacity recovered, following the combination therapy, as compared to Cisplatin alone. Our studies allowed us to conclude that the TrkB inhibition, efficiently impaired MEC cell migration, invasion and survival in vitro, however, the decrease in CSC number, following the combined treatment of ANA-12 and…[Read more]

  • platelet function, a surrogate outcome. Trials evaluating clinical and patient-important outcomes are needed to better inform medical practice and fill this gap in clinical knowledge.

    Preexisting alteration of the immune system by factors including older age, cardiovascular diseases, morbid obesity, diabetes, and chronic obstructive pulmonary…[Read more]

  • The prevalence of stroke among atrial fibrillation patients was 19.4% (95% confidence interval (CI) 14.9-25.2). Patients with heart failure (adjusted odds ratio (AOR) 5.70, 95% CI 2.50-13.24) and thyroid disorder (AOR 4.98, 95% CI 1.47-16.85) are at risk of developing stroke.

    The prevalence of stroke was higher compared with others…[Read more]

  • As expected, groups 1A and 5 showed the clear presence and lack of HER2 copy number gain, respectively, as measured by ddPCR and NGS. In contrast, group 1B and other uncommon FISH groups (groups 2-4) were characterized by a broader range of HER2 copy levels with only a few select cases showing high-level gain. Notably, these cases with increased…[Read more]

  • Kaya Mckay posted an update 8 months, 1 week ago

    s. Patient populations and unit factors need to be carefully considered and procedures developed to manage unique challenges.BACKGROUND Hospital-Acquired Infections (HAIs) are acquired when the patient is hospitalized for more than 48 hours. In Ethiopia data are scarce in management appropriateness of HAIs. Hence, this study was aimed to assess…[Read more]

  • Many are banking on this massive volume of diverse molecular data for breakthroughs in drug discovery and predicting sensitivity to risk factors, response to therapies and susceptibility to diabetes complications, as well as the development of disease-monitoring tools and surrogate outcomes. To realise these possibilities, it is essential that…[Read more]

  • There was also a reduction in the status of the biomarkers at the end of the study.

    Long-term therapy with Omalizumab was effective and safe in treating severe persistent allergic rhinitis and concomitant asthma.

    Long-term therapy with Omalizumab was effective and safe in treating severe persistent allergic rhinitis and concomitant…[Read more]

  • The presented findings indicate that strength training effects seem at least partly to be interrelated with alterations of the oxidant-antioxidant balance generated by the 8-week Qigong training in young sedentary females.This study investigated the effects of participating in an educational exercise program on physical fitness and gross motor…[Read more]

  • A detailed history and complete clinical examination of the patient with the soft tissue injury are needed to identify and diagnose the most probable underlying cause of that specific injury. The presented case is of a chemical burn due to formocresol, presenting with moderate pain and burning sensation with respect to a patch of darkly discolored…[Read more]

  • The tetrachoric correlation is a popular measure of association for binary data and estimates the correlation of an underlying normal latent vector. However, when the underlying vector is not normal, the tetrachoric correlation will be different from the underlying correlation. Since assuming underlying normality is often done on pragmatic and not…[Read more]

  • In this review, we will discuss the current knowledge on the dual role of dendritic cells in lipid accumulation, as wells as in the triggering of hepatic inflammation and hepatocytes cell death in metabolic steatohepatitis.Epstein Barr virus (EBV) is one of the most successful pathogens in humans with more than 95% of the human adult population…[Read more]

  • The novel material also shows excellent photothermal efficacy (p = 0.0002) in a 4T1 xenograft mice model. The organic nature of the material coupled with its small size and strong NIRF provides an advantage for bio-elimination and potential clinical image-guided therapy over the inorganic counterparts.Linaridins are members of the ribosomally…[Read more]

  • Conversely, PEGylation at other positions (Q1353-A1-domain and M1545-A2-domain) had limited effects on VWF clearance or binding to LRP1.Novel N-linked glycan chains were introduced at N1803 and N1807 in the A3-domain. In contrast to PEGylation at these sites, no significant extension in half-life was observed with these N-glycan variants.…[Read more]

  • Attention bias modification (ABM) was initially developed with the goal of reducing attentional bias to threat-and subsequently anxious symptoms-in individuals with heightened anxiety. Although controversial, ABM appears to be generally effective in achieving this goal. Yet, the primary outcome measure of ABM (i.e., the reaction time-based…[Read more]

  • o registered nurses and the effects on their performance which includes stress or moral distress from work overload and lengthy hours shift which impact the nurses’ physical, psychological, social, and family relationship, and lack of leadership support. The findings can be helpful to policy makers at the decision-making level to resolve the…[Read more]

  • The clinical cure rate was higher in Staphylococcus hominis (100%) and in patients who received 6 mg/kg/dose twice daily (62.5%). The mean of aspartate aminotransferase significantly elevated after starting daptomycin (p = 0.048). However, no muscular or neurological toxicity of daptomycin was documented in any of the cases. Overall, daptomycin…[Read more]

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