• In rodents, stimulation of the nucleus accumbens shell (AcbSh) directly or via its projection to the lateral hypothalamus (LH) attenuates food intake. The ventral pallidum (VP) receives dense projections from the AcbSh and is sensitive to the hedonic aspect of food and motivation for reward. However, the role of accumbal projections to the VP in…[Read more]

  • There is an urgent need for novel drugs for treating cognitive deficits that are defining features of schizophrenia. The individual d- and l-enantiomers of the tetrahydroprotoberberine (THPB) d,l-govadine have been proposed for the treatment of cognitive deficiencies and positive symptoms of schizophrenia, respectively.

    We examined the…[Read more]

  • Patients with poor functional status required more care than those capable of undertaking normal activities. Patients diagnosed as having liver cancer required more care than those with lung or colorectal cancer. Patients with advanced cancer required more physical and daily care than those with early-stage cancer.

    Patients’ health care…[Read more]

  • Oh Miranda posted an update 8 months, 1 week ago

    ROC analysis revealed that the rCBVs in habitats had great ability to discriminate IDH mutation from their wild type in all groups. In addition, the Kaplan-Meier survival analysis yielded significant differences for the survival times observed from the populations dichotomized by low ( 4.31) rCBV in the low-angiogenic enhancing tumor habitat. C…[Read more]

  • RT-qPCR requires an adequate choice of stably expressed reference genes for accurate normalization of mRNA expression. However, testing a panel of reference genes is often time-consuming and expensive. In this work, we aimed to develop a set of multiplex real-time PCR assays for RT-qPCR analysis of commonly used housekeeping genes in laboratory…[Read more]

  • BACKGROUND Night-shift lifestyles affect children as well as adults, and are associated with sleep and behavioral problems among children. This study aimed to investigate associations among sleep patterns, individual/environmental factors, and problematic behaviors in children at age 5 years. METHODS Data for sleep patterns,…[Read more]

  • Rouse Lu posted an update 8 months, 1 week ago

    Shikonin up-regulated mitochondrial biogenesis to increase mitochondrial oxidative phosphorylation in HepG2 cells, but displayed the opposite trend in HCCLM3 cells. Mechanistically, shikonin promoted nuclear expression of PKM2 and HIF1α in HCCLM3 cells, with upregulation of glycolysis-related gene transcription and glycolysis.

    These…[Read more]

  • OBJECTIVE Impulsive decision-making is characterized by actions taken without considering consequences. Patients with Parkinson’s disease (PD) who receive dopaminergic treatment, especially dopamine agonists, are at risk of developing impulsive-compulsive behaviors (ICBs). We assessed impulse-related changes across a large heterogeneous PD…[Read more]

  • Few studies have investigated the measurement error of the Mini-Mental State Examination (MMSE) in the same unit of measurement, also known as absolute reliability. This measurement can help determine whether an observed score change for an individual is likely to represent true change. The aim of this study was to investigate the absolute…[Read more]

  • will inform the development of policies to increase male partner involvement in PMTCT in Nigeria.

    Meningitis is a leading cause of death among patients living with HIV. There is no adequate tracking of the disease occurrence, distribution and etiologic agents among this risk group in Egypt, although the pattern could differ from that of the…[Read more]

  • Taken together, our results indicate that Tablysin-15 significantly suppresses osteoclastogenesis in vitro and in vivo, thus it might be a excellent candidate for treating osteolytic-related diseases.Alcoholic liver disease (ALD) is a progressively aggravated liver disease with high incidence in alcoholics. Ethanol-induced fat accumulation and the…[Read more]

  • 3532), but absence of a large target lesion was associated with improved PFS (P = 0.0222). Merestinib Grade 3 and 4 liver function abnormalities were rare and did not appear to be associated with high baseline liver tumour burden. CONCLUSIONS 177Lu-Dotatate demonstrated significant prolongation in PFS versus high-dose octreotide LAR in pat…[Read more]

  • es being non-significant. PBF can contribute to a better management of malnutrition at HC level; yet, to address the huge problem of child malnutrition in Burundi, additional strategies are urgently required.HIV-1 infection exhibits a significant sex bias. This study aimed at identifying and examining lymphocyte associated sex differences in HIV-1…[Read more]

  • 84 (CI-0.79-0.87). Agreement diminished with protocol A to ICC=0.62 (CI-0.37-0.76) and improved with protocol B to ICC=0.90 (CI-0.86-0.92). Intra-observer agreement without protocol was ICC=0.87, with protocol A ICC=0.87, and with protocol B ICC=0.93. The biggest improvement was seen for urologists’ agreement from no protocol to protocol B, where…[Read more]

  • Over the last 20 years, the designs of tissue engineered heart valves have evolved considerably. An initial focus on replicating the mechanical and structural features of semilunar valves has expanded to endeavors to mimic the biological behavior of heart valve cells as well. Studies on the biology of heart valves have shown that the function and…[Read more]

  • Mortality rates from chronic kidney disease (CKD) have increased in the last decade. In this pre-specified analysis of the DAPA-CKD trial, we determined the effects of dapagliflozin on cardiovascular and non-cardiovascular causes of death.

    DAPA-CKD was an international, randomized, placebo-controlled trial with a median of 2.4 years of f…[Read more]

  • This first-generation barley pan-genome makes previously hidden genetic variation accessible to genetic studies and breeding.Intensive fisheries have reduced fish biodiversity and abundance in aquatic ecosystems worldwide1-3. ‘No-take’ marine reserves have become a cornerstone of marine ecosystem-based fisheries management4-6, and their benefits…[Read more]

  • Although roots are mainly embedded in the soil, recent studies revealed that light regulates mineral nutrient uptake by roots. However, it remains unclear whether the change in root system architecture in response to different rhizosphere nutrient statuses involves light signaling. Here, we report that blue light regulates primary root growth…[Read more]

  • Bech Fog posted an update 8 months, 1 week ago

    Higher trauma scores were significantly associated with poor functioning and higher positive and negative symptom severity at 24 months, but not at baseline and 12 months of follow-up.

    Differential effects of CT on clinical outcome may not be apparent at psychosis onset, but only become evident through poor symptomatic remission and…[Read more]

  • Flood Kuhn posted an update 8 months, 1 week ago

    Currently, the immunotherapy approved for gastric cancer is immune checkpoint blockade( ICB) therapy. The effects of ICB depend on the T cell-mediated immune response elicited at the cancer site. Adenosine disodium triphosphate clinical trial Based on the results of previous clinical trials, it is clear that an enhanced immune response to cancer…[Read more]

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