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Hvidberg Brix posted an update 8 months, 1 week ago
Microcomputed tomography and morphometric analysis revealed that a four-week oral administration of LLEP notably decreased trabecular bone loss. Taken together, our results suggest that LLEP can mitigate estrogen deficiency-induced bone loss by suppressing osteoclastogenesis, which makes it an excellent candidate for combating…[Read more]
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McKenna Beasley posted an update 8 months, 1 week ago
BCRP is a potential biomarker of poor prognosis in BCa. BCRP expression is regulated by 17α-PG in mPRα-positive BCa cells through the PI3K/Akt/mTOR signaling pathway. Rapamycin might enhance the therapeutic effect of chemotherapy agents in mPRα-positive MDA-MB-453/BCRP cells and might be a therapeutic option for mPRα-positive invasive BCa with BCR…[Read more]
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Tuttle Malling posted an update 8 months, 1 week ago
Moreover, three hub genes, i.e. ESR1, NCOA3, and RPS6KB1 and one significant module were filtered out and selected from the PPI network. CONCLUSION Nobiletin might serve as a lead compound for the development of CSCs-targeted drugs by targeting estrogen and Wnt/ß-catenin signaling. Further studies are needed to explore the full therapeutic…[Read more]
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Ibsen MacKinnon posted an update 8 months, 1 week ago
Newborn screening revealed a diagnosis of SCD-SS type. At 83 days of life, the infant presented with swelling and tenderness of the left leg. Imaging revealed a non-displaced fracture of the femoral shaft. The patient was evaluated for OI and genetic testing confirmed the diagnosis of OI type 1. CONCLUSIONS An association between SCD and OI is…[Read more]
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Noel Han posted an update 8 months, 1 week ago
Online supplemental material is available for this article.Background Cerebrospinal fluid-venous fistulas (CVFs) are one of the less common etiologic causes of spontaneous intracranial hypotension. DMH1 inhibitor CVFs are most commonly treated with open surgical ligation and have reportedly not responded well to percutaneous treatments. Purpose To…[Read more]
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Lund Molloy posted an update 8 months, 1 week ago
Exposure differences ranged from -5.3 µg/m3 to 12.4 µg/m3 (up to 26% difference) during pregnancy and -7.22 µg/m3 to 7.64 µg/m3 (up to 27% difference) in the first year of life, when comparing estimated exposure using the address at birth and that assessed using the complete cleaned address history. For the majority of individuals exposure ch…[Read more]
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Mccullough Garner posted an update 8 months, 1 week ago
Our computational study not only provides a new class of 2D materials to enrich the material genome database, but also paves the way for practical applications of 2D III-V materials for electronic and optoelectronic devices.Post-synthetic modification of a dynamic carborane-based soft porous crystal (1 ⊃ DMF) by in situ polymerization of pyrrole t…[Read more]
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Kilgore Hsu posted an update 8 months, 1 week ago
The bile salt export pump (BSEP/ABCB11) is located on the apical membrane and mediates the secretion of bile salts from hepatocytes into the bile. BSEP-mediated bile salt efflux is the rate-limiting step of bile salt secretion and the main driving force of bile flow. BSEP drives and maintains the enterohepatic circulation of bile salts. In recent…[Read more]
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McGuire Dotson posted an update 8 months, 1 week ago
Interstitial lung disease is a well-recognised manifestation and a major cause of morbidity and mortality in patients with connective tissue diseases. Interstitial lung disease may arise in the context of an established connective tissue disease or be the initial manifestation of an otherwise occult autoimmune disorder. Early detection and…[Read more]
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Willard Joyner posted an update 8 months, 1 week ago
Therefore, our results suggest that timing and subsequent differentiation in robust cell-type proportions can emerge from the cooperative behaviour of growing cell populations during development.Stem cells are maintained in specific niches that strictly regulate their proliferation and differentiation for proper tissue regeneration and renewal.…[Read more]
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Owen Gravgaard posted an update 8 months, 1 week ago
Korthalsia laciniosa (Griff.) Mart. is a climbing rattan used as a source of durable and flexible cane. In the present study, the draft genome of K. laciniosa was sequenced, de novo assembled and annotated. Genome-wide identification of MADS-Box transcription factors revealed loss of Mβ, and Mγ genes belonging to Type I subclass in the rattan l…[Read more]
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Travis Smedegaard posted an update 8 months, 1 week ago
Additionally, user application can be executed directly in the SoC. It works in the -40 to +105 °C temperature range with a 1.5 V supply. The assembled test-chip takes 100 pins in a QFN (quad-flat no-leads) package and needs only a quartz crystal for the on-chip reference clock driver and optional SAW (surface acoustic wave) filters. The radio…[Read more]
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Coyle Duke posted an update 8 months, 1 week ago
monocytogenes. The biological activity of MV-associated listeriolysin O, internalin B, and phosphatidylinositol-specific phospholipase C (PI-PLC) was investigated using epithelial cell cytotoxicity. The reduced cytotoxicity was observed in Δhly MVs on Caco-2 cells suggesting that MVs are biologically active. It is shown that a potent toxin LLO…[Read more]
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McCulloch Valdez posted an update 8 months, 1 week ago
Crucial factors affecting the extraction efficiency, including sample solvent, elution solvent, flow rates of sampling loading and elution, sample loading volume, and elution volume, were investigated in details. Under the optimal in-tube SPME conditions, the proposed method showed good reproducibility with run-to-run, column-to-column, and…[Read more]
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Mathiasen Patton posted an update 8 months, 1 week ago
Exposure therapy is a well-studied and highly efficacious treatment for phobic disorders. Although the neurobiological model of fear is well underpinned by various studies, the mechanisms of exposure therapy are still under discussion. Partly, this is due to the fact that most neurophysiological methods like fMRI are not able to be used in the…[Read more]
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Petterson Mccormick posted an update 8 months, 1 week ago
Many human activities are tactile. Recognizing how a person touches an object or a surface surrounding them is an active area of research and it has generated keen interest within the interactive surface community. In this paper, we compare two machine learning techniques, namely Artificial Neural Network (ANN) and Hidden Markov Models (HMM), as…[Read more]
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Morton Washington posted an update 8 months, 1 week ago
Dairy cows are negatively affected by the introduction of bovine viral diarrhea virus (BVDV), and consequently, produce less milk. Existing literature on potential milk production losses is based on relatively outdated data and hardly evaluates milk production loss in relation to a new BVDV infection in a surveillance system. Picrotoxin antagonist…[Read more]
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Parks Kolding posted an update 8 months, 1 week ago
Nitrogen nutrient salts are considered the major environmental factors (RNH4+-N0.92, RTN0.85) affecting the structure and distribution of denitrogen bacteria. We aimed to investigate the mechanisms by which wetland bacteria adapt to environmental factors in different types of habitats. High-throughput sequencing technology was used to study the…[Read more]
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Rush Hougaard posted an update 8 months, 1 week ago
gher risk for postoperative complications, including a 7-fold increase in mortality. These findings suggest that ASD surgery should be postponed in patients experiencing a delay, until modifiable risk factors can be medically optimized, and perhaps postponed indefinitely in those with nonmodifiable risk factors.
This was a prospective…[Read more]
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Koefoed Stone posted an update 8 months, 1 week ago
Evidence assessment Because of limited and inadequate evidence, the USPSTF concludes that the benefits and harms of primary care-based interventions to prevent illicit drug use in children, adolescents, and young adults are uncertain and that the evidence is insufficient to assess the balance of benefits and harms. More research is needed.…[Read more]
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