• A special interest is given to PNS, induced by immune checkpoint-inhibitors (ICIs).Expert opinion Research in PNS, including the group of ICI-induced PNS provide new insights in both the pathophysiology of PNS and tumor immune interactions and offers new treatment options for this group of severe neurological diseases.Introduction In…[Read more]

  • The approval of 223Ra dichloride (223RaCl2) in 2013 was a principal event in introducing targeted α-therapy as a form of safe and effective management strategy in cancer. There is an increasing interest in research and development of new targeted α-therapy agents spearheaded by advancements in cancer biology, radiochemistry, and availability of c…[Read more]

  • Furthermore, the amounts of sample produced permitted initial small angle X-ray scattering studies providing the first structural information about TF and its binding to FVIIa in a lipid environment. This strategy possibly allows for probing the multicomponent complex TFFVIIa together with its substrate Factor X on a lipid bilayer, but may also be…[Read more]

  • Sauer Leth posted an update 8 months, 1 week ago

    2%-83.7%) of total costs. New indirect cost items were identified to be insurance difficulty, exercise impairment, and caregiver income loss. Donors from lower-income households and those who traveled long distances reported the greatest financial hardship.

    Most kidney donors are undercompensated. Our findings highlight gaps in donor…[Read more]

  • Hvid Lamb posted an update 8 months, 1 week ago

    Hepatitis C virus (HCV) infection is a major public health issue leading to chronic liver diseases. HCV particles are unique owing to their particular lipid composition, namely the incorporation of neutral lipids and apolipoproteins. The mechanism of association between HCV virion components and these lipoproteins factors remains poorly understood…[Read more]

  • Compared to the Historical simulation, the projections show a tendency to increase of maximum and minimum temperature in the future, and a tendency to decrease relative humidity. There is an increase in the number of days with the potential for the occurrence of the disease. The distribution of days with favorable conditions to rust disease tends…[Read more]

  • Koch Pape posted an update 8 months, 1 week ago

    OBJECTIVE Understanding factors that promote and hinder the recovery process for people living with serious mental illness remains of critical importance. We examine factors, including limited literacy, associated with mental health recovery among public mental health service users. METHOD This study uses data from a mixed-methods, service-user…[Read more]

  • With this retrospective, single center, chart review study, we investigate the self-reported benefit and weakness after botulinum toxin injections in three different types of dystonia focal hand dystonia (FHD), blepharospasm and cervical dystonia. We found that the benefit lasts significantly longer in FHD compared to the other two groups.A…[Read more]

  • The patients with malignant pleural mesothelioma showed a five-fold higher expression in the APEX2, BRCA1, BRCA2, CDK7, MLH1, MLH3, MSH3, MSH4, NEIL3, PARP2, PARP3, PMS1, RAD50, RAD51, RAD51B, RAD51D, RAD52, RPA3, SMUG1, UNG, XPA, XRCC2, and XRCC4 genes, compared to the control group. Comparing malignant pleural mesothelioma with lung…[Read more]

  • AV-45 (florbetapir f18, Amyvid) is an FDA-approved PET imaging agent targeting Aβ plaques in the brain for diagnosis of Alzheimer’s disease (AD). Its metabolites led to a high background in the brain and large bone uptake of F-, produced from dealkylation of the PEG chain. To slow down the in vivo metabolism, we report the design, synthesis, and…[Read more]

  • Brevetoxins were confirmed in urine specimens from patients diagnosed with neurotoxic shellfish poisoning (NSP) after consumption of gastropods that were recreationally harvested from an area previously affected by a Karenia brevis bloom. Several species of gastropods (Triplofusus giganteus, Sinistrofulgur sinistrum, Cinctura hunteria, Strombus…[Read more]

  • se of and/or carry naloxone, than those who did not receive tangible support. Future work on the social relationships of PWSD may prove valuable in the search for credible and effective interventions.

    Successful implantation and delivery require both the functional embryo and receptive endometrium in assisted reproductive technology (ART)…[Read more]

  • The purpose of this study was to develop and validate a positioning method with hand-guiding and contact position feedback of robot based on a human-robot collaborative dental implant system (HRCDIS) for robotic guided dental implant surgery.

    An HRCDIS was developed based on a light-weight cooperative robot arm, UR5. A three-dimensional…[Read more]

  • Chemical synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor action but show a critical loss of inside vitro serum stability.

    A slightly steeper decline in verbal ability over 12 years was observed in those with higher Mediterranean-style diet scores at baseline (β = -0·003, P = 0·008). All other associations were no…[Read more]

  • Platelet-poor plasma gel is a semi-solid plasma formulation that recently recommended as autologous bio-filler for treatment of atrophic dermal scars.

    To compare the therapeutic efficacy and safety of intradermal injection of plasma gel in combination with fractional CO

    laser versus fractional CO

    laser alone in striae distensae…[Read more]

  • It also has potential for broader metabolic perturbation studies to better understand metabolism.The production of blood cells during steady-state and increased demand depends on the regulation of hematopoietic stem cell (HSC) self-renewal and differentiation. Similarly, the balance between self-renewal and differentiation of leukemia stem cells…[Read more]

  • Results The literature reveals different protocols that provide for bone reduction with a variety of bone reduction methods. The digitally-planned surgical guide based on Cone-Beam computerized tomography (CBCT) scan reconstructed data can improve accuracy, reduce surgical time, and deliver the desired bone level for the implant placement with…[Read more]

  • Pain is a severe and common symptom in patients receiving dialysis but remains inadequately managed in clinical practice. Understanding patient experiences of pain can inform strategies to address this patient-important symptom. We aimed to describe patients’ perspectives on causes, experiences and impacts of dialysis-associated pain. MEDLINE,…[Read more]

  • esidential. A fully-powered trial is warranted to reliably test the effectiveness of Parent SMART and understand possible mechanisms of improvement.

    No validated tools exist to screen for substance use or dependence in Mozambique. The aim of this study was to validate the Alcohol Use Disorder Identification Test (AUDIT) for use in primary care…[Read more]

  • 001 for both comparisons) and serum sclerostin 30.9 ± 31.9 vs 26.9 ± 21.1 pmol/L (p = 0.516). Positive correlation was found between BIA and DXA SMI × Baumgartner (r = 0.842; p  less then  0.001) and fat mass (r = 0.970; p  less then  0.001). Gait speed was relatively preserved in sleeve gastrectomy (SG) compared with Roux-en-Y gastric bypass…[Read more]

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