• BACKGROUND AND OBJECTIVE To evaluate impact of baseline systemic dipeptidyl peptidase-4 (DPP-4) inhibitor use in diabetic macular edema (DME). PATIENTS AND METHODS This was a post hoc exploratory analysis of previously completed randomized, controlled clinical trials (VISTA and VIVID) in patients with DME evaluating intravitreal aflibercept…[Read more]

  • Falk Balle posted an update 8 months, 1 week ago

    Obstacle avoidance is one of the skills required in coping with challenging situations encountered during walking. This study examined adaptation in gait stability and its interlimb transfer in a virtual obstacle avoidance task. Twelve young adults walked on a treadmill while wearing a virtual reality headset with their body state represented in…[Read more]

  • The coated surfaces also killed stationary-phase cells of MRSA, which cannot be eradicated by traditional antibiotics. Upon hydrolysis, the surfaces switched to an antifouling state displaying significant reduction in bacterial adherence. To the best of our knowledge, this is the first report of an antimicrobial coating which could kill all of…[Read more]

  • Biopolymers are rapidly gaining attention as sustainable precursors for lightweight porous materials for energy-saving, pharmaceutical, catalysis, and environmental remediation applications. Chitosan is an abundant biopolymer derived from food waste with attractive properties, particularly its high biocompatibility and easy chemical…[Read more]

  • Very recent developments have allowed for single-cell sequencing and cell-type resolution of gene expression and function. In the near future, we will therefore likely see a multitude of breakthrough biomarkers, developed from a deepened understanding of the biological function of individual cell types in the healthy and injured liver.The rapid…[Read more]

  • OBJECTIVE To determine the prognostic value of atrial fibrillation (AF) in patients with heart failure (HF) and preserved, mid-range or reduced ejection fraction (EF). METHODS Patients hospitalised for acute HF were enrolled in the Korean Acute Heart Failure registry, a prospective, observational, multicentre cohort study, between March 2011 and…[Read more]

  • Reece Ray posted an update 8 months, 1 week ago

    In addition, the dosage of 8-12 mg/kg/day was powerful against Enterococcus faecium for adolescents; however, only the highest dosage of 12 mg/kg/day was effective for infants aged 3-12 months and children. All the simulated regimens were not optimal for infants aged 13-24 months. These PK/PD-based simulations rationalize and optimize the dosage…[Read more]

  • We also observed that ERP latency depended on the conditions. Our study suggests that odor habituation can involve the olfactory ERP of odors within 200 ms in the brain.The efficient and timely degradation of proteins is crucial for many cellular processes and to maintain general proteostasis. The proteasome, a complex multisubunit protease, plays…[Read more]

  • Glioblastoma multiforme (GBM) is a grade IV glioma and accounts for 15% of all primary brain tumors. This GBM has a median survival range of less than 2 years after diagnosis and it is highly vascularized by neoformed vessels. Neoangiogenesis is a crucial factor in the malignant tumoral behavior and prognosis of patients and Nestin protein belongs…[Read more]

  • We also noted that these laboratories are little or almost not assisted and that there was no coordination team dedicated to the supervision and the assessment of laboratories in the hospital or even in the health zone. In addition, technicians working in their different laboratories had not been supervised over many years. Conclusion Clinical…[Read more]

  • Kok Ayala posted an update 8 months, 1 week ago

    Differences in GMV in congenital anosmia are most likely due to the fact that patients were never able to smell.This study aimed to compare the efficacy of XP-endo Finisher R and IrriSafe, with a solvent mixture of Methyl ethyl ketone/Tetrachloroethylene (MEK/TCE), in the removal of root filling residues. Twenty-four human mandibular incisors were…[Read more]

  • ; however, there remain important sociodemographic groups that have not secured the same deceleration in death rates.

    COPD mortality has decreased among Americans overall; however, there remain important sociodemographic groups that have not secured the same deceleration in death rates.Purpose The purpose of this study was to examine pain…[Read more]

  • The results show that the proposed system could provide 38 control commands with a 2 s time window and a good accuracy (i.e., 96.92%) using one bipolar electroencephalogram (EEG) channel. This work presents a novel BCI approach for the home automation application based on SSVEP and eye blink signals, which could be useful for the disabled. In…[Read more]

  • Cho Beard posted an update 8 months, 1 week ago

    Further, our detailed phytochemical analysis of the methanolic extracts of the P. patens allowed to deduce that compounds, which strongly suppressed the growth and proliferation of HeLa cancer cells were mainly triterpenoid saponins accompanied by phenolic acids.The prevalence of Type 2 Diabetes has reached an epidemic proportion particularly in…[Read more]

  • Nitrification inhibitors can reduce nitrous oxide (N2O) emissions and nitrate leaching losses from agricultural soils. Technologies have been developed to detect and target urine patches for inhibitor application, thereby reducing the total amount of inhibitor used. However, in practice there will be a time delay between the urine deposition and…[Read more]

  • 7 min (OR 3.63, 95% CI 1.36-9.67; p value = 0.01) and hypercapnic acidosis × TTI ≦ 10.4 min (OR 2.27, 95% CI 1.20-4.28; p value = 0.01) were associated with survival. Intra-arrest blood gas analysis may help guide TTI during for patients with IHCA.Inquiline ants are highly specialized and obligate social parasites that infiltrate and exploit co…[Read more]

  • Effective control of pain management has the potential to significantly decrease the need for prescription opioids following a surgical procedure. While extended release products for pain management are available commercially, the implementation of a device that safely and reliably provides extended analgesia and is sufficiently flexible to…[Read more]

  • gher risk for postoperative complications, including a 7-fold increase in mortality. These findings suggest that ASD surgery should be postponed in patients experiencing a delay, until modifiable risk factors can be medically optimized, and perhaps postponed indefinitely in those with nonmodifiable risk factors.

    This was a prospective…[Read more]

  • Perinatal hypoxic ischemic encephalopathy (HIE) results in serious neurological dysfunction and mortality. Clinical trials of multilineage-differentiating stress enduring cells (Muse cells) have commenced in stroke using intravenous delivery of donor-derived Muse cells. Here, we investigated the therapeutic effects of human Muse cells in an HIE…[Read more]

  • Researchers increasingly recognize that stakeholder involvement enhances research relevance and validity. However, reports of patient engagement in research that relies on administrative records data are rare. The authors’ collaborative project combined quantitative and qualitative studies of costs and access to care among U.S. adults with…[Read more]

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