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MacDonald Robbins posted an update 1 year, 1 month ago
te that the ubiquitin-proteasome system might not be the main mechanism of mutant dysferlin degradation. However, its inhibition could help to improve muscle inflammation by reducing TSP-1 release.
Our findings indicate that the ubiquitin-proteasome system might not be the main mechanism of mutant dysferlin degradation. However, its inhibition…[Read more]
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Yang Lowry posted an update 1 year, 1 month ago
Research examining bone marrow adipose tissue (BMAT) has rapidly expanded during the last two decades, leading to advances in knowledge on the role of BMAT in the pathogenesis of bone loss and endocrine disorders. Clinical imaging has played a crucial role for the in vivo assessment of BMAT, allowing non-invasive quantification and evaluation of…[Read more]
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Parks Kolding posted an update 1 year, 1 month ago
Scenario one predicts the acute effects of a change in carbohydrate input in lipid profiles. The results present progressive triglyceride accumulations in the liver and plasma for three diets. The rate of accumulation was greater in the fructose diet than that of the mixed or glucose only models. Scenario two explores the variability of metabolic…[Read more]
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McCulloch Valdez posted an update 1 year, 1 month ago
BACKGROUND Spontaneous intracerebral hemorrhage (ICH) is a medical emergency that requires rapid identification and focused assessment early to ensure the best possible outcomes. read more The purpose of this study is to evaluate the associations between system and patient factors and emergency department (ED) length of stay and in-hospital…[Read more]
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Thomassen Soto posted an update 1 year, 1 month ago
Organ fibrosis is a common pathological outcome of persistent tissue injury correlated with organ failure and death. Although current antifibrotic therapies have led to unprecedented successes, only a minority of patients with fibrosis benefit from these treatments. There is an urgent need to identify new targets and biomarkers that could be…[Read more]
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Kofod Gray posted an update 1 year, 1 month ago
The aim of the study was to investigate General Movements'(GMs) neonatal trajectories and their association with neurodevelopment at three months corrected age (CA) in preterm infants. We conducted an observational, longitudinal study in 216 very low birth weight infants. GMs were recorded at 31 ± 1, 35 ± 1, 40 ± 1 weeks of postmenstrual…[Read more]
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McDonough Kaspersen posted an update 1 year, 1 month ago
On the other hand, the goals of different institutions varied in context, while others were redundant and lacked synergy. As a result, urban rivers and river buffers accommodate various land uses that are negatively affecting the potential of rivers and river buffers in benefiting communities. Finally, the study forwarded critical methodological…[Read more]
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George Barnett posted an update 1 year, 1 month ago
Two were OOT over the full dose range one elected not to remeasure; the other also had positional discrepancy greater than 1 mm and repeat measurement with a new plan was in tolerance. The original OOT was attributed to inappropriate MLC constraints. All centres delivered planned target-cord dose gradient within 1 mm. CONCLUSION Credentialing…[Read more]
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Bojsen Juhl posted an update 1 year, 1 month ago
Despite heterogeneity, an increased prevalence of psychological comorbidity and an altered pronociceptive gut microenvironment have repeatedly emerged as causative pathophysiology in patients with irritable bowel syndrome (IBS). Our aim was to study these phenomena by comparing gut-related symptoms, psychological scores, and biopsy samples…[Read more]
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Hawley McCall posted an update 1 year, 1 month ago
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is a low-abundance membrane lipid essential for plasma membrane function1,2. In plants, mutations in phosphatidylinositol 4-phosphate (PI4P) 5-kinases (PIP5K) suggest that PI(4,5)P2 production is involved in development, immunity and reproduction3-5. However, phospholipid synthesis is highly…[Read more]
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Aguilar Webb posted an update 1 year, 1 month ago
g., aesthetic) or functional (i.e., reinforcer quality and availability) variables. Preference was found to be functionally related to reinforcer availability, including when rapidly alternated between modalities. Moreover, the participant consistently allocated responding away from the control condition. Implications for self-determination and…[Read more]
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Clay Conradsen posted an update 1 year, 1 month ago
Unexpectedly, nitric oxide levels were overall lower after the immune challenge than before. These effects were probably mediated by melatonin, as ALAN-treated birds had on average 49% lower melatonin levels than the dark-night birds. ALAN exposure did not have any clear effects on nestling growth. This study provides a potential physiological…[Read more]
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Copeland Wollesen posted an update 1 year, 1 month ago
ic mechanism.
Coronavirus disease 2019 is an emerging highly communicable disease. Nosocomial transmission needs to be prevented through the implementation of stringent screening and infection control measures.
The objective of the study is to estimate the prevalence of severe acute respiratory syndrome- coronavirus 2 (SARS-CoV-2)…[Read more]
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Falk Balle posted an update 1 year, 1 month ago
The effect of living with a smoker on physical inactivity was stronger than that of patient status. Moreover, the living with a smoker effect on physical inactivity remained stable across eight years. These findings highlight an overlooked impediment to compliance with recommendations for lifestyle change among high-risk medical patients.Extended…[Read more]
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Hutchison Ayers posted an update 1 year, 1 month ago
l-Ascorbic acid (LAA) is considered a powerful antioxidant that protects skin from premature aging. Maintaining the stability of vitamin C remains the biggest challenge in cosmeceuticals. Our main aim is the entrapment of high dose of vitamin C in spanlastic vesicles to provide maximum stability and efficacy. LAA-loaded spanlastics were prepared…[Read more]
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Andreassen Klein posted an update 1 year, 1 month ago
RCCX haplotypes with two copies of the CYP21A2 gene and one copy of the CYP21A1P pseudogene have been widely described in different populations. In most cases, the CYP21A2-like gene downstream of the TNXA gene showed a wild-type sequence or the c.293-13A/C > G variant while the CYP21A2 gene next to TNXB carried the p.(Gln319Ter) variant. Here is…[Read more]
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Hatfield Williamson posted an update 1 year, 1 month ago
Numerous advances have been made in the field of spine fusion, such as minimally invasive (MIS) or robotic-assisted spine surgery. However, it is unknown how these advances have impacted the cost of care.
Compare the economic outcomes of lumbar spine fusion between open, MIS, and robot-assisted surgery patients.
Retrospective…[Read more]
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Kemp Schack posted an update 1 year, 1 month ago
Moreover, measurements were highly repeatable within and among both experienced and inexperienced observers. Our results, validated by genetic evidence, demonstrate that malar measurements provide accurate identifications of B. vagans and B. sandersoni. There was considerable overlap in the measurements between B. perplexus and B. sandersoni.…[Read more]
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McCormack Funch posted an update 1 year, 1 month ago
3±1.4. The mean number of medications used at 12, 18 and 24 months was respectively 2.6±1.5, 2.5±1.4 and 2.2±1.5. Postoperative complications included cystic macular edema (n=2), hypotony maculopathy (n=1), fibrinous/uveitic reaction (n=1) and rejection of corneal graft (n=1), all reversible after treatment. One patient developed persisting hyp…[Read more]
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Bonner Mikkelsen posted an update 1 year, 1 month ago
004, p = 0.008, p less then 0.001 respectively). selleck Possible threshold values to predict failure of APAP titration were found as 40 min and 135 min for nREM3 and REM latencies, respectively. The best threshold for minimum SpO2 was 86% with an 86.4% of sensitivity. Despite the high negative predictive values (81% for nREM3 latency, 75% for REM…[Read more]
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