• Recently major efforts have been made to define the oligometastatic setting, but for head and neck cancer (HNC) limited data are available. We aimed to evaluate outcome of oligometastatic HNC treated with Stereotactic body radiotherapy (SBRT) as metastasis-directed therapy.

    We analyzed patients treated with SBRT on a maximum of five…[Read more]

  • Yu Lyng posted an update 7 months, 3 weeks ago

    To carry out prenatal diagnosis for a fetus with increased nuchal translucency (NT) and another fetus with non-invasive prenatal testing (NIPT) suggested reduced sex chromosomes by cytogenetic and molecular techniques.

    Chromosomal karyotyping, single nucleotide polymorphism array (SNP-array) and fluorescence in situ hybridization (FISH)…[Read more]

  • Noel Han posted an update 7 months, 3 weeks ago

    The development, fast-tracking, and approval of SARS-CoV-2 nanotechnology-based vaccines has transformed the seemingly daunting challenges for clinically translating nanomedicines into measurable hurdles that can be overcome. Due to the tremendous scientific achievements that have occurred in response to the COVID-19 pandemic, years, perhaps even…[Read more]

  • aestivum. PRACTICAL APPLICATIONS The current study indicated that the potent efficacy of imidacloprid against different aphid spp. which were the most insect pest in wheat plants. As well as the application of imidacloprid as seed dressing insecticide, significantly increase carbohydrate, protein, amino acids, and RNA content in T. aestivum…[Read more]

  • Background Several strategies have been proposed to determine onset of puberty without examination by a trained professional. This study sought to evaluate a novel approach to determine onset of puberty in girls. Methods This study utilized the Cincinnati cohort of the Breast Cancer and the Environment Research Program. Girls were recruited at 6-7…[Read more]

  • OBJECTIVE To systematically review and appraise published data, to determine the prevalence of Mycoplasma genitalium (MG) in men who have sex with men (MSM) tested at each anatomical site, that is, at the urethra, rectum and/or pharynx. DESIGN Systematic review and meta-analysis. DATA SOURCES Ovid Medline, PubMed, Embase were searched for articles…[Read more]

  • While religiosity is usually associated with lower death anxiety, holding doubts about one’s faith are associated with higher death anxiety. Using longitudinal data from the Religion, Aging, and Health Study (2001-2004), this study examines within-individual changes in religious doubt and death anxiety. Results from lagged dependent variable…[Read more]

  • Treatment with the clinical ATR kinase inhibitor VX-970 induced apoptosis in MYB-positive ACC cells and growth inhibition in ACC PDXs. To our knowledge, ATR is the first example of an actionable target downstream of MYB that could be further exploited for therapeutic opportunities in ACC patients. Our findings may also have implications for other…[Read more]

  • Precursor B-cell lymphoblastic lymphoma (PBLL) is a rare subtype of non-Hodgkin lymphoma originating from B-cell precursors. PBLL, as a solitary mass lesion affecting the central nervous system without leukemic disease at presentation, is quite uncommon. Here we report a rare PBLL case with Philadelphia chromosome positivity. The 44-year-old male…[Read more]

  • Female patients who had been sexually assaulted and who were evaluated at 13 widely geographically distributed sexual assault nurse examiners’ programs consistently reported that the sexual assault nurse examiners provided high-quality, compassionate care.

    We aimed to assess the long-term outcomes of children in whom the aortic valve could be…[Read more]

  • Pyroptosis is a type of proinflammatory regulated cell death (RCD) in which caspase-1 proteolytically cleaves gasdermin D (GSDMD) to yield a cytotoxic pore-forming protein. Recent studies have suggested that additional cell death pathways may interact with GSDMD under certain circumstances to execute pyroptosis. Microglia/macrophages in the…[Read more]

  • To investigate the evidence and provide clinical recommendations for low intensity exercises(LIE) and blood flow restriction(BFR) without exercise on reducing the effects of exercise induced muscle damage(EIMD).

    PubMed, Embase, Web of science, and PEDro(Physiotherapy Evidence Database) were searched up to December 2019 for studies that…[Read more]

  • To identify health professionals awareness of stroke rehabilitation guidelines, and factors perceived to influence guideline use internationally.

    Online survey study. Open-ended responses were thematically analysed, guided by the Consolidated Framework for Implementation Research.

    Data from 833 respondents from 30 countries were…[Read more]

  • 1 MPa), and the elongation is 19.9%, 39.8% lower than that of pure aluminum (33.1%).This study examined the cross-sectional and longitudinal association of sleep timing with weight status in 14- to 19-year-old adolescents in Wuhan, China. A prospective school-based study was conducted in Wuhan, China between 28 May and 29 September 2019. Data on…[Read more]

  • We do believe that a rapid reduction of all modifiable risk factors, especially obesity with its metabolic complications, should be a pillar of public health policies and interventions, in view of future waves of SARS-CoV-2 infection.Trastuzumab resistance in HER2-positive breast cancer is associated with a poorer prognosis. HSP90 is thought to…[Read more]

  • Cancer is one of the most serious health concerns in 21st century whose prevalence is beyond boundaries and can affect any organ of human beings. The conventional chemotherapeutic treatment strategies lack specificity to tumours and are associated with toxic effects on immune system and other organ systems. In the past decades, there has been a…[Read more]

  • PERCIST measurements were performed for each paired baseline and post-treatment scan. Receiver operating characteristic analysis for the prediction of pCR was performed using logistic regression that included age and tumor size as covariates. SUV and SUL metrics were significantly different between orientation (P .6). Overlapping 95% confidence…[Read more]

  • A unique lanthanide complex which responds to near-infrared (NIR) stimulation was developed for remote regulation of cellular events. This molecule can be localized specifically on the cell surface. Upon NIR stimulation, strong emission of the complex can successfully modulate the activities of light-gated membrane channels and regulate the ion…[Read more]

  • Leishmaniasis is a neglected disease caused by Leishmania. Chemotherapy remains the mainstay for leishmaniasis control; however, available drugs fail to provide a parasitological cure, and are associated with high toxicity. Natural products are promising leads for the development of novel chemotherapeutics against leishmaniasis. This work…[Read more]

  • Sexual and gender minority (SGM) individuals experience minority stress, especially when they lack social support. SGM young adults may turn to social media in search of a supportive community; however, social media use can become problematic when it interferes with functioning. Problematic social media use may be associated with experiences of…[Read more]

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