• Clinical pharmacology is also applied in direct patient care with the goal of personalizing treatment. Tools such as therapeutic drug monitoring, pharmacogenomics and model informed precision dosing are used to optimize dosing for patients at an individual level. In KSA, the science of clinical pharmacology is underutilized and we believe it is…[Read more]

  • There was an increasing trend of proliferative and cell growth related genes and shutting down of immune response as the disease progress mild to moderate to advanced stage cirrhosis. The myriad of changes in gene expression showed more chances of developing liver cancer in patients infected with HCV genotype 3a in a systematic manner. The…[Read more]

  • Our proposal can easily be extended to systems that include multiple quantum emitters interacting through hyperbolic metasurfaces and thus may have potential applications in on-chip science that aims at quantum information processing and quantum networks.Speckle-correlation imaging is a family of methods that makes use of the “memory effect” to…[Read more]

  • Therefore, it is critical that multidisciplinary service providers, including health professionals, employers, social services providers, educational institutions and community organizations, move toward online service delivery, so that homebound HIV-positive LGBT+ individuals are secured with a wide range of care options. Non-judgemental,…[Read more]

  • Nance May posted an update 7 months, 3 weeks ago

    A basic paradigm underlying the Hookean mechanics of amorphous, isotropic solids is that small deformations are proportional to the magnitude of external forces. However, slender bodies may undergo large deformations even under minute forces, leading to nonlinear responses rooted in purely geometric effects. Here we study the indentation of a…[Read more]

  • In addition, the results of clinical studies showed that TXYF has good efficacy and few adverse reactions in the treatment of UC. Although it has achieved some success, the research is limited by deficiencies; there is a lack of unified standards for the construction of UC animal models and for administration regimen. In addition, the dosage of…[Read more]

  • ignificantly increased the facet joint pressure and decreased the range of motion; therefore, it should not be used in clinical practice.

    This study suggested that an appropriate artificial disc height can achieve near-normal biomechanical properties and is recommended. We should be very cautious when using artificial discs ≥ 1 mm in heigh…[Read more]

  • 26±0.114, 1.05±0.181, and 0.59±0.074MPa, respectively. The periods of time needed to achieve effective thrombolysis were measured at 0.8, 2, and 4mJ/cm

    laser fluence levels and 0.42, 0.70, and 0.98MPa negative ultrasound pressures. In general, thrombolysis could be achieved more rapidly with higher laser powers or ultrasound pr…[Read more]

  • are potential candidates for becoming antimicrobial agents.Short sequences of DNA immobilized on gold surfaces can be used to capture an array of target molecules because of their high level of specificity. Depending on the nature of the target molecules, the proper density and distribution of the immobilized DNA molecules are fundamental to the…[Read more]

  • Photonic delay-based reservoir computing (RC) has gained considerable attention lately, as it allows for simple technological implementations of the RC concept that can operate at high speed. In this paper, we discuss a practical, compact and robust implementation of photonic delay-based RC, by integrating a laser and a 5.4 cm delay line on an InP…[Read more]

  • Breast cancer is the most common cancer among women worldwide. Medical ultrasound imaging is one of the widely applied breast imaging methods for breast tumors. Automatic breast ultrasound (BUS) image segmentation can measure the size of tumors objectively. However, various ultrasound artifacts hinder segmentation. We proposed an…[Read more]

  • These designs merge experimental analysis of behavior methods used for decades in psychology with new methodological and statistical advances to assess significance levels of changes in individual patients, and they can be generalized to larger populations for meta-analytic purposes. This article presents a case for why these models are needed, an…[Read more]

  • 5 pM. Moreover, this aptasensor exhibited excellent precision, as well as high repeatability, hence possessing potentials in real samples and for diverse targets detection by easy replacement of the matched aptamer.Despite growing demands for high-temperature wastewater treatment, most available polymeric membranes are limited to mild operating…[Read more]

  • A new three-dimensional style of temporary bioheat exchange within the lower extremity throughout cryotherapy.

    051). The SPEED scores negatively correlated with LLT in all patients (r=-0.136, p<0.001). check details Younger patients also had thinner average LLT (p<0.001), lower meiboscale (p<0.001) and a higher number of expressible meibomian…[Read more]

  • 84) and 86.7% (Kappa = 0.73), respectively. The area under the curve (AUC) of the ACR-TIRADS and EU-TIRADS were 0.871 and 0.828, respectively (p < 0.001). The EU-TIRADS had the best SEN and NPV, whereas the ACR-TIRADS had the best SPE, PPV, and ACC. Only 33.4% of the nodules followed the FNA size criteria suggested by the ACR-TIRADS.…[Read more]

  • Data were entered to Epi data version 3.1 then exported to SPSS version 23 for analysis. Bivariate logistic regression was employed to examine the statistical association between dependent and independent variables. Variables with p value less then  0.25 in binary logistic regression were entered to multivariable logistic regression model and v…[Read more]

  • Type 2 Diabetes mellitus (T2DM) is a multifactorial and polygenic disorder with the molecular bases still idiopathic. Experimental analyses and tests are quite limited upon human samples due to the access, variability of patient’s conditions, and the size and complexity of the genome. Therefore, high-sugar diet exposure is commonly used for…[Read more]

  • 05) and the 95% bivariate contour ellipse area (

    < .05) in group A were respectively higher and lower than those in group B. However, the average thresholds around the PRLs in the two groups showed no significant difference (

    > .05).

    A PRL to the left of or above a scotoma tends to develop to avoid the right and inferior field…[Read more]

  • Liver cirrhosis is the final stage of many chronic liver diseases, and is still a heavy disease burden. The proportion of liver cirrhosis caused by the hepatitis B virus is declining, while that caused by the non-alcoholic fatty liver disease (metabolic-associated fatty liver disease) is rising. Several predictive models and techniques such as…[Read more]

  • In the first scenario, the simulation resulted in a ventricular pause of 1333ms (Boston Scientific), 2000ms (Medtronic and Microport), and 2340ms (Biotronik). In the second and third scenario, different results were observed across devices. All simulations of the second and third scenario resulted in repetitive 21 block response (during eight…[Read more]

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