• Camp Borg posted an update 7 months, 3 weeks ago

    Endothelin-converting enzyme-1 (ECE1) activates the endothelin-1 peptide, which upregulates pathways that are related to diverse hallmarks of cancer. ECE1 is expressed as four isoforms differing in their N-terminal domains. Protein kinase CK2 phosphorylates the N-terminus of isoform ECE1c, enhancing its stability and promoting invasiveness of…[Read more]

  • To determine the presence of SCE, we examined supine chest X-rays obtained after the completion of surgery.

    We found 55 cases (24.0%) of SCE. Multiple logistic regression analysis showed that a BMI < 25 kg/m

    (OR 3.0, 95% CI 1.25-7.26) and a maximum value of PetCO

    of 46 mmHg or greater (OR 23.3, 95% CI 8.22-66.1) were independent…[Read more]

  • To assess the frequency with which soft drinks and premiums are available with children’s meals marketed on the top restaurant chains’ websites worldwide.

    Cross-sectional structured observational assessment of secondary information about top international restaurant chain children’s meals.

    Websites of top restaurant chains for 193…[Read more]

  • We observed that defective GCase activity promotes the release of EVs, independently of mutation severity. Moreover, small EVs released from PD fibroblasts carrying severe mutations increased the intra-cellular levels of phosphorylated α-syn. In summary, our work shows that the dysregulation of small EV trafficking and alpha-synuclein mishandling…[Read more]

  • The conversion of CO2 into fuels and feedstock chemicals via photothermal catalysis holds promise for efficient solar energy utilization to tackle the global energy shortage and climate change. Despite recent advances, it is of emerging interest to explore promising materials with excellent photothermal properties to boost the performance of…[Read more]

  • The introduction further provides policy implications drawn from the conclusions of the studies and some thoughts for future studies to consider.In this work, we propose a parameter estimation framework for fracture propagation problems. The fracture problem is described by a phase-field method. Parameter estimation is realized with a Bayesian…[Read more]

  • tive compounds in OO. .Genetic information, both germline and somatic, is an increasingly important consideration in therapeutic decision-making in cancer. Germline mutations in genes associated with increased cancer risk can identify those individuals without cancer who may benefit from enhanced screening and prevention strategies. In individuals…[Read more]

  • Hydrogels are an important class of biomaterials with the unique property of high-water content in a crosslinked polymer network. In particular, chemically crosslinked hydrogels have made a great clinical impact in past years because of their desirable mechanical properties and tunability of structural and chemical properties. Various polymers and…[Read more]

  • Predictors of ISR were determined by multivariate logistic regression analysis.

    Follow-up angiography demonstrated ISR in 33 patients (24.8%). In 44 patients, more than two stents were deployed. Univariate logistic regression analyses demonstrated echolucent lesion, floating plaque, complete occlusive or pseudo-occlusive lesion, and…[Read more]

  • This work afforded a feasible strategy via inorganic-organic combination to distinguish trace RH and improved the operation stability of 2D material-based sensors, simultaneously demonstrating realistic monitoring applications of exhaled gas detection and distance variation of moisture-emitting objects.Benefiting from superior programmability and…[Read more]

  • Bean Gray posted an update 7 months, 3 weeks ago

    Our previous study demonstrated that lysine demethylase 2A (KDM2A) enhances stemness in breast cancer cells. This demethylase is also highly expressed in cancer-associated fibroblasts (CAFs). However, its clinical significance is unclear.

    The expression of KDM2A in CAFs was studied using immunohistochemical staining and its association…[Read more]

  • 168% and 21.529%). The pooled odd ratios comparing D-MMR to proficient MMR favored low-stage EC disease (1.565; 0.894 to 2.740), lymphovascular invasion (1.765; 1.293 to 2.409), and myometrial invasion >50% (1.271; 0.871 to 1.853).

    Almost one-quarter of EC patients present with D-MMR tumors. The majority has less aggressive endometrioid…[Read more]

  • In recent years, huge amounts of antibiotics have been administered to farm animals, and as a result, residues of these antibiotics can accumulate in livestock products and, once consumed, may be transmitted to humans. Farm animals’ antibiotic treatment may therefore present a risk for consumers health, especially for children and adolescents. In…[Read more]

  • HER2-positive breast cancers are among the most heterogeneous breast cancer subtypes. The early amplification of HER2 and its known oncogenic isoforms provide a plausible mechanism in which distinct programs of tumor heterogeneity could be traced to the initial oncogenic event. Here a Cancer rainbow mouse simultaneously expressing fluorescently…[Read more]

  • Integration of transesophageal echocardiography (TEE) with Focused Cardiac Ultrasound (FoCUS) can impact decision-making, assist in the diagnosis of reversible etiologies and help guiding resuscitation of patients with cardiac arrest.

    To evaluate the ability of emergency physicians (EPs) to obtain and maintain skills in performing resusTEE…[Read more]

  • amounts of cooled saline may be the ideal combination for implant osteotomy site preparation. Key wordsHeat generation, dental implant drills, drilling speed, drilling pressure, irrigation, infrared thermography, thermal necrosis, osteotomy preparation.

    Ectopic teeth in maxillary sinus is rare and are usually removed via sub-labial…[Read more]

  • Our work suggests that ribavirin has advantage than many anti-cancer agents by targeting both tumor cells and angiogenesis. Our work also highlights the therapeutic potential of ribavirin for the treatment of lung cancer.Immunodeficient rats are valuable in transplantation studies, but are vulnerable to infection from opportunistic organisms such…[Read more]

  • Ae. aegypti was the dominant species representing 56.6% of this fauna with a high plasticity. Ae. furcifer and Ae. luteocephalus were found in forest tree holes, Ae. taylori in forest and village tree holes, Ae. vittatus in rock holes. ZIKV was detected from 4 out of the 82 mosquito pools tested. Positive pools included Ae. bromeliae (2 pools),…[Read more]

  • 05). Co-culture with mTCs may be used as an effective method to differentiate hUCMSCs into germ-like cells. © 2020 Blackwell Verlag GmbH.Social rejection research has largely focused on the consequences of rejection when individuals experience rejection alone. Yet little is known about the reaction of those co-experiencing rejection. We tested…[Read more]

  • In Taiwan, the prevalent CSFV population has shifted from the historical genotype 3.4 (94.4 strain) to the newly invading genotype 2.1 (TD/96 strain) since 1996. This study analyzed the competition between these two virus genotypes in dual infection pigs with equal and different virus populations and with maternally derived neutralizing antibodies…[Read more]

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