• Giles Dennis posted an update 6 months, 3 weeks ago

    The currently reported procedures provide an easy-to-begin, flexible, readable, easy-to-modify basic tool set for EEG analysis and is expected to recruit new EEG researchers.In Iran, both Nepeta menthoides – the endemic species of Nepeta genus – and Lavandula officinalis are known as Ustukhuddoos and used widely as medicinal herbs. Nicotinamide Riboside chemical structure In Iranian traditional medicine, Ustukhuddoos has been recommended for several neuronal diseases including depression and epilepsy. While the antiepileptic effects of Lavandula officinalis have been investigated in a number of studies, no reports are available taking into account the effect of Nepeta menthoides on epilepsy. Since convulsion is an important side effect of some medicinal plants, a thorough study of the effects of Nepeta menthoides on epilepsy seems necessary. This study was designed to investigate the potential anti- or pro-convulsant activity of Nepeta menthoides and its effects on oxidative stress markers. Since an herbal medicine showed opposite effects in two animal models of epilepsy in our laboratory, authers decided to study Nepeta effects through several seizure tests including the intravenous pentylenetetrazol (i.v. PTZ) infusion, the maximal electroshock (MES), acute PTZ and PTZ-kindling tests. These seizure models are generally used for screening pro- or anti-epileptic drugs. Nepeta menthoides (400 mg/kg) significantly reduced the dose of PTZ necessary for clonus seizure induction. Combining either phenytoin (Phen) or Valproate (Val) with Nepeta decreased their antiepileptic effects. Therefore, Nepeta menthoides not only failed to prevent the seizures but also increased sensitivity to them. Nepeta raised brain NO levels in different seizure tests. It seems there is a relation between NO elevation by Nepeta and increased sensitivity to seizures that should be investigated later.Biochar is a chemically recalcitrant carbon-rich solid material used in soil for its potential to improve soil quality and sequester carbon. While the rate of application has implications for soil carbon dioxide (CO2) emission and the overall benefits of biochar, its effects are yet to be fully understood. To evaluate the effect of application rates of rice husk biochar on CO2 emissions, 91-day field experiments were conducted on three soil types (Anthraquic Ustorthent, Grossarenic Kandiustalf, and Ustic Quartzipsamment) in the southern Guinea Savannah of Nigeria, using three biochar application rates of 5, 15 and 25 t h-1, and control. A two-way ANOVA showed that cumulative CO2 emissions were significantly (p less then 0.01) different between soil types and treatments, and soil type/treatment interactions were also significant at p = 0.05. The highest cumulative CO2-C emission of 2.77g/m2 was recorded in the Grossarenic Kandiustalf, while the least value of 2.11g/m2 was recorded in the Ustic Quartzipsamment. CO2 emission increased with increasing biochar application rates, with the highest (3.06 CO2-C g/m2) value recorded at 25 t/ha compared to 2.78 g/m2 and 1.52 g/m2 values recorded for 5 t/ha and control treatments respectively. While CO2 emissions increased with biochar application rate however, the percentage of biochar-C mineralized was higher at lower biochar rates, and differences were significant at p = 0.01. While 0.63 % of biochar C was mineralized under 5 t/ha biochar treatment, 0.15 % was recorded for 25 t/ha treatment. Factors that had significant correlation with CO2-C emission in the soils were biochar addition rate, soil pH, N, P, Ca, Mg and K. At day 91, there were no significant differences in CO2 emissions between amended treatments and control, and only a small percentage ( less then 1) of biochar C had been mineralized.Microplastics (MP) pollution has become a matter of global concern because of its several deleterious effects on environmental health, especially on the terrestrial environment. The evidence of MP contamination in terrestrial environment is less explored compared to aquatic bodies. However, in Bangladesh despite having high possibility of MP contamination, there is lacking of available research-based evidence. Urban areas soil is subjected to act as a major environmental reservoir for MPs. Thus, this study was carried out to investigate the presence of MP contamination in constructed landfill sites near Dhaka city, Bangladesh. Ten unmixed soil samples were collected from the Aminbazar Sanitary landfill sites, from that thirty replicated samples were investigated via Fourier Transform Infrared Spectroscopy (FT-IR) analysis and Stereomicroscope. The range of physicochemical parameters were found in the soil samples as follows moisture content; 15.84%-56.54%; soil pH; 5.76-6.02, electric conductivity; 0.1 μs/cm – 2.43 μs/cm, alkalinity; 6.7 ± 1.528-14.33 ± 0.577, TOC; 0.18% ± 0.02-1.09 ± 0.03. Among the ten samples, 3 samples were identified to have the presence of MP in the form of Low density polyethylene (LDPE), High density polyethylene (HDPE), and Cellulose acetate (CA) respectively. The detection limit ranged from 1 – 2000 μm. Hence, the results show that the procurement and discharge of MPs in the landfills is an overlong process. The results of this study provide an initial evidence and affirm that landfill can be a potential source of MPs. This study indicates that MPs are comparatively overlong outcome of human induced activities which can significantly cause changes in terrestrial ecosystems.Zanthoxylum armatum (ZA) a commonly used medicinal plant was investigated for phytochemical, anti-nociceptive, anti-inflammatory and antipyretic effects. Extract and total alkaloids from fruit and leaves significantly (p less then 0.001) reduced the rectal temperature in mice. The effects of bark and root extracts were less significant. In writhing and tail flick methods both the extract and total alkaloids from fruit showed significant (p less then 0.05 and p less then 0.001) antinociceptive activity. The fruit extract and crude alkaloids showed significant (p less then 0.01) lowering of inflammation of paw edema in mice. Crude alkaloids from fruit and leaves showed significant enzyme inhibition with lower IC50 values for 15 and 69 against COX and 21 and 62 μg/ml against LOX. This study rationalize the usage of this spice in traditional medicine for management of pain and inflammation involving LOX and COX inhibition as possible mechanism. GC-MS analysis revealed the presence of various constituents which might contributed towards the pain and inflammation alleviation.

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