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Mcgowan Meadows posted an update 6 months ago
833. Importantly, HA alone yielded an AUROC of 0.828. Detection of CSPH in strictly compensated ACLD (cACLD) patients was less accurate AUROC0.759 (P less then 0.001). CSPH was ruled-in by ELF≥11.1 with a PPV of 98% (sensitivity61%/specificity92%/NPV24%), but CSPH could not be ruled-out. ELF score had a low AUROC of 0.677 (0.60-0.75; P less then 0.001) for the diagnosis of high-risk portal hypertension (HRPH; HVPG≥20mmHg) and thus, HRPH could not be ruled-in by ELF. However, ELF less then 10.1 ruled-out HRPH with a NPV of 95% (sensitivity97%/specificity26%/PPV39%). CONCLUSION The ELF score correlates with HVPG at values less then 20 mmHg. An ELF ≥11.1 identifies patients with a high probability of CSPH, while an ELF less then 10.1 may be used to rule-out HRPH. This article is protected by copyright. All rights reserved.To better understand the molecular basis of cancer, the NCI’s Clinical Proteomics Tumor Analysis Consortium (CPTAC) has been performing comprehensive large-scale proteogenomic characterizations of multiple cancer types. Gene and protein regulatory networks are subsequently being derived based on these proteogenomic profiles, which serve as tools to gain systems-level understanding of the molecular regulatory factories underlying these diseases. On the other hand, it remains a challenge to effectively visualize and navigate the resulting network models, which capture higher order structures in the proteogenomic profiles. There is a pressing need to have a new open community resource tool for intuitive visual exploration, interpretation and communication of these gene/protein regulatory networks by the cancer research community. In this work, we introduce ProNetView-ccRCC (http//ccrcc.cptac-network-view.org/), an interactive web-based network exploration portal for investigating phosphopeptide co-expression network inferred based on the CPTAC clear cell renal cell carcinoma (ccRCC) phosphoproteomics data. ProNetView-ccRCC enables quick, user-intuitive visual interactions with the ccRCC tumor phosphoprotein co-expression network comprised of 3,614 genes, as well as 30 functional pathway-enriched network modules. Users can interact with the network portal and can conveniently query for association between abundance of each phosphopeptide in the network and clinical variables such as tumor grade. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.We have read with great interest Dr Estébanez article regarding the case of a 28-year-old woman affected by COVID-19, presenting confluent erythematous-yellowish papules at both heels. After three days, the lesions persisted and became hardened erythematous plaques. This article is protected by copyright. All rights reserved.Melanoma metastasis to the brain is one of the most frequent extracranial brain tumors. Cell surface gangliosides are elevated in melanoma metastasis; however, the metabolic regulatory mechanisms that govern these specific changes are poorly understood in melanoma particularly brain metastases (MBM) development. We found ganglioside GD3 levels significantly upregulated in MBM compared to lymph node metastasis (LNM) but not for other melanoma gangliosides. Moreover, we demonstrated an upregulation of ST8SIA1 (GD3 synthase) as melanoma progresses from melanocytes to MBM cells. Using RNA-ISH on FFPE specimens, we evaluated ST8SIA1 expression in primary melanomas (PRM) (n=23), LNM and visceral metastasis (n=45), and MBM (n=39). ST8SIA1 was significantly enhanced in MBM compared to all other specimens. ST8SIA1 expression was assessed in clinically well-annotated melanoma patients from multicenters with AJCC stage III B-D LNM (n=58) with 14 year follow-up. High ST8SIA1 expression was significantly associated with poor overall survival (HR=3.24; 95% CI, 1.19-8.86, p=0.02). In a nude mouse human xenograft melanoma brain metastasis model, MBM variants had higher ST8SIA1 expression than their respective cutaneous melanoma variants. Elevated ST8SIA1 expression enhances levels of cell surface GD3, a phenotype that favors MBM development; hence associated with very poor prognosis. Functional assays demonstrated that ST8SIA1 overexpression enhanced cell proliferation and colony formation whereby, ST8SIA1 knockdown had opposite effects. Icaritin, a plant-derived phytoestrogen treatment significantly inhibited cell growth in high GD3 positive MBM cells through targeting the canonical NFκB-pathway. The study demonstrates GD3 phenotype associates with melanoma progression and poor outcome. This article is protected by copyright. All rights reserved.When I first read the manuscript that accompanies this editorial, upon its online publication on February 19th 2020(1), COVID-19 had already killed 2118 people in China, but only one person in Europe – an 80-year-old tourist from China, who died in France on the 15th February. RepSox I read the manuscript with grim fascination, as it was clear that SARS-CoV-2 had spread very rapidly in China which already had 74,576 cases and in South Korea which already had 58 cases, and that it was then invading Europe also, as France already had 12 cases, Germany 16, the UK 9, Italy 3, Spain 2 and other countries too. This article is protected by copyright. All rights reserved.Under China’s healthcare reforms, community health service centres (CHCs) have been established as the preferred primary care providers. Even with this change, there is still little attention paid to patients’ usual source of care (USC) from CHCs in Northeastern China. The main purposes of this study were to explore the determinants of usual source of community health service and to examine the association between usual source of community health service and patients’ experiences with primary care. A cross-sectional survey with 515 adult patients at CHCs in Jilin Province, China, was conducted between July 2016 and November 2016. The patients’ experiences with primary care were assessed with the Primary Care Assessment Tool (PCAT). Patients with self-perceived poor health status (odds ratio = 1.984, 95% confidence interval = 1.145-3.437) and chronic disease (odds ratio = 2.207, 95% confidence interval = 1.203-4.051) were more likely to have a usual source of community health service than patients with self-perceived good health status or without chronic disease.
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