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Le Honore posted an update 2 months ago
Effective decontamination procedures are critical to the successful manufacture and control of poliovirus vaccines to minimize the risk to personnel and the environment. Polio viruses have been reported to be more resistant to disinfectants than many other viruses. We assessed the efficacy of sodium hypochlorite-containing disinfectants for decontamination for three poliovirus serotypes to implement decontamination procedures that are fully compliant with the WHO GAP III and Health authorities’ requirements. A 10.4 log reduction was observed with a 0.63% sodium hypochlorite solution in a suspension with high protein and high poliovirus concentrations diluted 10-fold compared with a 6 log reduction in an undiluted sample. Treatment efficacy increased with sodium hypochlorite content and decreased with sample protein content. The surface tests showed that two 1-min treatments, 5-min apart, with a 0.63% Chl sodium hypochlorite solution effectively reduced the concentration of all poliovirus serotypes by 10 log10, irrespective of the protein and virus concentration in the sample. Sodium hypochlorite solutions lower than 0.52% were less effective for complete inactivation of poliovirus. In conclusion, we demonstrated that a high level of virus reduction (>10 log10) can be achieved with sodium hypochlorite solutions with poliovirus in suspension and dried on surfaces.
At our institution, on-call radiology residents perform emergent ultrasounds (US) outside of departmental working hours. The aim of the study was to evaluate radiology resident-performed US for clinically suspected acute appendicitis in women under the age of 40.
Retrospective review of 104 consecutive US scans outside of departmental working hours by radiology residents, and 104 consecutive US studies scanned during departmental working hours by sonographers, in women under the age of 40 for clinically suspected appendicitis .
Appendix visualization rate was 27% for the resident group (sonographer group 30%, p = 0.759). The sensitivity and specificity of US for appendicitis were 63% (95% confidence interval 41%-81%) and 98% (95% CI 91%-100%), respectively for the resident group (sonographer group 69% and 98% , respectively). An alternative cause for right lower quadrant pain was offered in 17% of resident group cases (sonographer group 21%, p = 0.598). Follow-up CT or MRI was performed in 47% of resident cases (sonographer group 44%, p = 0.781). Residents performed more focused US (i.e. not imaging the pelvic organs), at 34% (sonographer group 1%, p < 0.001). When only focused scanning was performed by residents, there was a trend toward increased downstream imaging (CT or MRI), odds ratio = 2.76 (95% CI 0.99-7.70).
Out-of-hours US scans performed by radiology residents had similar performance characteristics compared to departmental sonographers. We discovered an increased rate of downstream imaging in cases in which residents performed limited scans and did not document visualization of the pelvic organs.
Out-of-hours US scans performed by radiology residents had similar performance characteristics compared to departmental sonographers. We discovered an increased rate of downstream imaging in cases in which residents performed limited scans and did not document visualization of the pelvic organs.
Although metrics-based systems may incentivize academic output, no prior studies have evaluated the impact on publication metrics in academic radiology. This study presents a metrics-based system of awarding research protected time, and retrospectively evaluates its 9-year impact on publication productivity and impact factor.
Based on a metrics-based algorithm to award department funded Research Protected Time (RPT), metrics pre-RPT (2003-2009) and during the RPT period (2010-2018) from an academic radiology department were retrospectively analyzed to test the hypothesis that the RPT program resulted in higher publication productivity and journal impact factor at the departmental level and for faculty members receiving the award. Comparison was made between (1) pre-RPT and RPT periods and (2) during the RPT period, between RPT and non-RPT faculty members, for annual publication productivity normalized to faculty count (Student’s t test) and median impact factor (Wilcoxon rank sum test).
For the evaluation period of 2003-2018, 724 unique publications were identified 15% (107/724) pre-RPT period and 85% (617/724) RPT period. Donafenib clinical trial Normalized annual publication productivity was higher during the RPT period compared to the Pre-RPT period (1.2 vs. 0.3, p = 0.002), and within the RPT period, higher among faculty who received RPT vs. non-RPT faculty (3.5 vs. 0.4, p = 0.002). Median impact factor was higher during the RPT period compared to pre-RPT period (2.843 vs. 2.322, p = 0.044), and within the RPT period, higher in RPT vs. non-RPT faculty (3.016 vs. 2.346, p < 0.001).
The implementation of a metrics-based system of funded, research protected time, was associated with increased publication productivity and increased impact factor.
The implementation of a metrics-based system of funded, research protected time, was associated with increased publication productivity and increased impact factor.
To evaluate the training of computed tomography (CT)-guided periradicular therapy in a realistic simulation environment and to derive recommendations for a training curriculum.
A novel simulation environment including the use of a 3D printed, patient-mimicking phantom was used to train medical students to perform CT-guided periradicular therapy of the lumbar spine. Seventeen participants underwent three training sessions (day 0, day 7, and after day 28) with six procedures per session. Procedure duration and the number of fluoroscopy image acquisitions were recorded. Participants’ performance was assessed by an independent investigator using a six-point checklist scale (0 = lowest, 6 = highest). In addition, participants self-evaluated their skills and the simulation training in questionnaires.
Procedure durations and image acquisitions decreased after one training session (p < 0.001) without further improvement thereafter (p > 0.6). They also decreased within training sessions and were lowest after five procedures in all sessions.
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Start with a huge, uncovered box, or even a kiddie pool, and fill with a thick layer (about 6 inches) of unscented clay or fine sand-like particulate clumping/scoopable litter. For Ollie, you may need to play around with the substrate types to make it more natural. Try using soil or peat.