• Gormsen Erichsen posted an update 6 months, 3 weeks ago

    Sensor-based monitoring allows continuous observations of patient mobilization after proximal femoral fractures. Awrist-worn motion tracker allows long-term observation that is low in interruption and constraints for subjects.

    Description of steps development after hip fracture surgery on aspecialized geriatric trauma ward and beyond.

    In the explorative long-term field research study, an applicable motion tracker observed steps per day of 20patients (80% female, mean age 85.2 years ± 7.86 years) for 10 weeks. Weekly mean values (days1-7, 8-14 etc.) of steps per day formed the database for descriptive analysis (mean, SD, min, max, median).

    During observation weeks (ow) apositive development of steps took place. Amean increase factor of 1.285 (±0.351) occurred from ow1 (M = 353.57 ± 310.15) to ow 10 (M = 2482.07 ± 1374.12). The highest increase by a factor of 1.8 could be reported from ow2 (M = 556.27 ± 478.11) to ow 3 (M = 1024.86 ± 921.24) as well as from ow6 (M = 1268.21 ± 880.47) to 7 (M = 2367.14 ± 1680.08). Aslight decrease of steps occurred from ow4 (M = 1208.27 ± 1210.45) to ow 5 (0.99-fold) and from ow9 (M = 2689.98 ± 2339.71) to 10 (0.92-fold). High ranges and standard deviations in relation to the mean occurred constantly. The presence of several step development groups could be presumed.

    Motion tracker and the variable steps per day can represent the ability to walk within an everyday environment, with apossible underestimation of < 10%. Differences regarding observation lengths and disruptions occurred. Cluster analysis should detect group attributes of different courses of development in subsequent studies.

    Motion tracker and the variable steps per day can represent the ability to walk within an everyday environment, with a possible underestimation of less then  10%. Differences regarding observation lengths and disruptions occurred. Cluster analysis should detect group attributes of different courses of development in subsequent studies.

    This study aimed to determine (1) intramuscular regional differences in the changes in the shear modulus of the rectus femoris (RF) muscle during passive knee flexion and (2) the relationship between shear modulus and passive knee extension torque.

    The shear modulus maps as an index of muscle stiffness and the passive torque were obtained at seven regions during passive knee flexion at 2°/s within a knee joint range of motion of 0°-130° in 16 healthy males.

    The shear modulus of RF increased with the knee angle of flexion. The shear modulus of each longitudinal region was greater in the order of proximal, central, and distal region (p < 0.05). The relationship between the shear modulus and passive torque was highly fitted for all 16 subjects (p < 0.05). The mean coefficient of determination (R

    ) at second-order polynomial model per subject was 0.96 (± 0.03; range 0.61-0.99), and whole group was 0.58 (± 0.03; range 0.54-0.64) in all regions.

    The passive stiffness of RF was higher in the proximal region than in the other regions during passive knee flexion. Furthermore, the shear modulus-passive torque was related regardless of the measurement region within a muscle, and the results suggest that the passive knee extension torque reflects passive muscle stiffness of the RF.

    The passive stiffness of RF was higher in the proximal region than in the other regions during passive knee flexion. Furthermore, the shear modulus-passive torque was related regardless of the measurement region within a muscle, and the results suggest that the passive knee extension torque reflects passive muscle stiffness of the RF.

    Cold-induced vasodilation (CIVD) is a paradoxical rise in blood flow to the digits that occur during prolonged cold exposure. CIVD is thought to occur through active vasodilation and/or sympathetic withdrawal, where nitric oxide (NO) may play a key role in mediating these mechanisms. Beetroot juice (BRJ) is high in dietary nitrate (NO

    ) which undergoes sequential reduction to nitrite (NO

    ) and subsequently NO. Using a double-blind, randomized, crossover design, we examined the effect of acute BRJ supplementation on the CIVD response in 10 healthy males.

    Participants had a resting blood pressure measurement taken prior to ingesting 140mL of nitrate-rich BRJ (13mmol NO

    ) or a NO

    -free placebo (PLA). After 2h, participants immersed their hand in neutral water (~ 35°C) for 10min of baseline before cold water immersion (~ 8°C) for 30min. Laser-Doppler fluxmetry and skin temperature were measured continuously on the digits.

    Compared to PLA (100 ± 3mmHg), acute BRJ supplementation significantly reduced mean arterial pressure at -30min (96 ± 2mmHg; p = 0.007) and 0min (94 ± 2mmHg; p = 0.008). Acute BRJ supplementation had no effect on Laser-Doppler fluxmetry during CIVD (expressed as cutaneous vascular conductance) measured as area under the curve (BRJ 843 ± 148 PUmmHg

    s; PLA 1086 ± 333 PUmmHg

    s), amplitude (BRJ 0.60 ± 0.12 PUmmHg

    ; PLA 0.69 ± 0.14 PUmmHg

    ), and duration (BRJ 895 ± 60s; PLA 894 ± 46s).

    Acute BRJ supplementation does not augment the CIVD response in healthy males.

    Acute BRJ supplementation does not augment the CIVD response in healthy males.The mechanism of the antimicrobial peptide daptomycin is reviewed and discussed. Daptomycin is a last-resort antibiotic in current use against drug-resistant bacterial infections. Many models have been proposed for its function, most based on the observation that it increases membrane permeability and causes leakage of contents, such as ions and small molecules from bacterial cells and lipid vesicles. selleck chemicals However, daptomycin is actually not efficient at permeabilizing or translocating across membranes, contrary to many well-known antimicrobial peptides. There is strong evidence that daptomycin binds preferentially to membranes in active division regions of bacterial cells and that it causes large membrane reorganization in terms of the distribution of lipids and proteins, both in cells and in model membranes. Those observations support the alternative hypothesis for the mechanism of daptomycin that its primary effect is in inducing membrane reorganization and that other events, such as increased membrane leakage and depolarization, are secondary consequences, not essential to its function.

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