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Yu Lyng posted an update 6 months ago
The present study aimed to evaluate surgical treatments, complications and neurological outcomes of patients with cavernous malformations (CMs) in the pons and medulla oblongata.
We retrospectively evaluated 25 brain stem CMs that we operated between 2009 and 2019. GSK2578215A We operated all cases in the first month with suboxypital retrosigmoid and paramedian approach. The cases were evaluated concerning their demographic characteristics, lesion characteristics, radiological imaging results, surgical approach and neurological status.
Overall, 15 patients had CMs in the pons and 10 in the medulla oblongata. The mean age of the patients was 33.48 years, and the cases included 15 male and 10 female patients. The average modified Rankin Score (mRS) score had a mean of 2.36 and median of 2 at the time of admission (Table 1). The mean follow-up period was 4.64 years (1-10 years). In the last follow-up assessment, the average mRS score was mean = 1.84 and median = 1. In addition, 14 (56%) patients recovered, 7 (28%) did not show any changes, 3 (12%) got worse, and 1 (4%) died. In our case series, the admission complaints were cranial nerve paralysis (24%) in 6 cases, nausea and vomiting in 1 (4%) and hemiparesis in 17 (68%).
Experience, correct surgical approach and good knowledge of neuroanatomy are important in brainstem CM haemorrhages. Imaging methods, neuronavigation and neuromonitoring use are essential for patients undergoing surgery. In the presence of all these factors, the prognosis of patients will be better.
Experience, correct surgical approach and good knowledge of neuroanatomy are important in brainstem CM haemorrhages. Imaging methods, neuronavigation and neuromonitoring use are essential for patients undergoing surgery. In the presence of all these factors, the prognosis of patients will be better.
To investigate the visual analogue scale and “Oswestry Disability Index” scores after the removal of the instrumentation system in patients who underwent lumbar instrumentation for lumbar degenerative disease (LDD).
This study included 30 patients (19 female, 11 male) who had undergone posterior lumbar instrumentation for LDD in whom postoperative continuous or recurrent pain led to the removal of the implant system in our clinic between December 2013 and December 2019. The patients had continuous or recurrent low back pain that did not respond to medical treatment, physical therapy, or any type of lumbar block. Nine patients had continuous low back pain in the surgical area, while twenty-one had recurrent low back pain Results There was a significant reduction in the number of admissions to the hospital (p 0.001) and the daily number of analgesics used (p 0.001) in six months after surgery compared to six months before surgery. There were significant decreases in visual analog scale scores, both at the one-month (p 0.001) and six-month (p 0.001) postoperative assessments compared to preoperative measurements. Oswestry disability index scores were significantly lower than the preoperative scores at both one-month (p 0.001) and six-month (p 0.001) postoperative score.
Our study showed that the instrumentation system removal after fusion for patients with LDD may be beneficial since it alleviates pain and analgesic usage.
Our study showed that the instrumentation system removal after fusion for patients with LDD may be beneficial since it alleviates pain and analgesic usage.
To evaluate the relationship between the time from termination of anticoagulant/antiplatelet medication to surgery and the risk of acute postoperative hemorrhage in CSDH patients.
A retrospective study of patients who underwent bur hole craniotomy for CSDH between December 2014 and December 2019 was performed. Demographic and clinical data of age, gender, medication (antithrombotic therapy), smoking, daily alcohol consumption, history of head trauma, presenting symptoms and neurological examination were collected from medical records. Patients were divided into 3 groups according to the time of surgery from referral; 1st group within 24 hours; 2nd group between 24 to 72 hours; 3rd group after 72 hours.
In the 5-year period, 117 patients underwent CSDH surgery. 72 of 117 patients were male (61.5%) and 45 of 117 patients were female (38.5%). The mean age was 70.5 ± 7.2 years. Postoperative ASDH was observed in 2 of 32 patients (6.3%) without any antithrombotic medication history and 6 of 85 patients (7.1%r referral.
Surgery is an important treatment strategy for patients with spinal tuberculosis. This study evaluated the association between in-hospital outcomes of patients with spinal tuberculosis and different surgical approaches.
This population-based, retrospective observational study analyzed data of hospitalized patients undergoing surgical treatment for spinal tuberculosis in the United States who were identified in the US Nationwide Inpatient Sample (NIS) between 2005 and 2014. The study cohort was stratified by posterior-only, anterior-only, and combined surgical approaches. Logistic and linear regression analyses were performed to evaluate associations between surgical approaches and patient outcomes.
Significant differences were found in postoperative complications, number of instrumented levels, and comorbidity scores (all p ≤ 0.033) between patients who received differentsurgical approaches.A univariate analysis demonstrated the combined approach was associated with significantly increased oddsof postopength of stay compared with an anterior-only or combination approaches when performed at the lumbo-sacral spinal level.
Mild traumatic brain injury (TBI) may cause cognitive and emotional behavioural disorders. Following head trauma, magnesium concentration in brain tissues decreases; consequently, low magnesium concentrations are responsible for secondary injury processes. We recently demonstrated that magnesium acetyl taurate can effectively pass from systemic circulation into brain tissue, but its functional effectiveness in head trauma is yet unclear. The aim of this study was to investigate the effects of different magnesium forms on tissue damage and behavioural impairment after mild TBI.
Rats were divided into 5 groups (control, trauma, magnesium sulphate, magnesium citrate, magnesium acetyl taurate) and following head trauma, empathy-like behaviour, anxiety-like behaviour (elevated plus maze and open field tests), and depression (forced swim test) were measured. The rats were then sacrificed 12 days later. Oxytocin, vasopressin and receptors levels in the amygdala and prefrontal cortex regions were measured. Histopathological damage (with haematoxylin-eosin staining) and apoptosis (with caspase-3 immunohistochemistry) was evaluated.