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Chase Warming posted an update 6 months ago
Tropical deforestation drivers are complex and can change rapidly in periods of profound societal transformation, such as those during a pandemic. Evidence suggests that the COVID-19 pandemic has spurred illegal, opportunistic forest clearing in tropical countries, threatening forest ecosystems and their resident human communities. A total of 9583 km2 of deforestation alerts from Global Land Analysis & Discovery (GLAD) were detected across the global tropics during the first month following the implementation of confinement measures of local governments to reduce COVID-19 spread, which is nearly double that of 2019 (4732 km2). We present a conceptual framework linking tropical deforestation and the current pandemic. Zoonotic diseases, public health, economy, agriculture, and forests may all be reciprocally linked in complex positive and negative feedback loops with overarching consequences. We highlight the emerging threats to nature and society resulting from this complex reciprocal interplay and possible policy interventions that could minimize these threats.
To report a case of bilateral spontaneous filtering bleb, scleral thinning, microspherophakia, and mild craniofacial dysmorphism.
An 18-year-old girl was referred to our clinic for evaluation of bilateral spontaneous filtering blebs. Her corrected distance visual acuity (CDVA) was 20/400 in the right eye (RE) and 20/100 in the left eye (LE). She had superior scleral thinning, multicystic filtering bleb, and microspherophakia bilaterally. The IOP was 9mmHg in the RE and 8mmHg in the LE. A mild craniofacial dysmorphism including downward slanting of palpebral fissures and malar hypoplasia was present. There was no sign of corneal ectasia in tomography. Anterior segment optical coherence tomography revealed the filtering blebs as subconjunctival low reflective fluid-filled spaces. Due to severe scleral thinning un the RE we performed a tectonic scleral patch graft. 6 months after surgery the depth of the anterior chamber increased and CDVA improved.
This case indicated that the formation of spontaneous filtering blebs may occur in a syndromic condition. In any case with this symptom, special attention should be paid to craniofacial features, sclera, crystalline lens, and IOP. Tectonic scleral patch graft could be a valuable option in selected patients.
This case indicated that the formation of spontaneous filtering blebs may occur in a syndromic condition. In any case with this symptom, special attention should be paid to craniofacial features, sclera, crystalline lens, and IOP. Tectonic scleral patch graft could be a valuable option in selected patients.We have developed a new and facile one pot three component protocol catalyzed by ammonium acetate for construction of new functionalized 7-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives. A variety of quinoline derivatives were obtained in good to excellent yield from inexpensive reagents and catalyst in mild reaction conditions that provide atom economy and cost efficacy. selleckchem Various spectroscopic techniques like FTIR, 1HNMR and 13CNMR were employed to study their structure while mass of the synthesized compounds were confirmed through MALDI-TOF-MS and EI mass spectrometry.
Restricting community mobility during COVID-19 can potentially trigger anxiety, depression and stress in the community. The study aims to analyze variables associated with the community psychosocial burden (anxiety level) during the co-19 pandemic in Indonesia.
This study collected data (n = 8,031) online. Psychosocial burden was measured based on the anxiety level which include 5 aspects, such as economic, religious, educational, employment, and social issues. Each question used a Likert scale. Six independent were examined, such as age, gender, religion, marital, education, and employement. In the final stage, a multivariate test was performed using a multinomial logistic regression.
Someone older experienced less high anxiety. The age group of 20-29 years was 4,330 times likely to experience higher anxiety than the age group of ≥50 years. While, those in the age group of 40-49 years weer 2,322 times more likely to have higher anxiety than those in the age group of ≥50 years. Male respondents had lower possibility of medium to high anxiety than females. Respondents with secondary and lower education had 3,117 times possibilities to experience higher anxiety than those with high education level.
Four variables affected the psychosocial burden i.e, anxiety level of community in Indonesia. These involved age, gender, education, and employement.
Four variables affected the psychosocial burden i.e, anxiety level of community in Indonesia. These involved age, gender, education, and employement.This paper discusses an optimization model for handling the impact of the COVID-19 pandemic based on food supply network through regional food hubs (RFHs) under uncertainty. To this end, uncertainty is assumed in the demand and production data. During the Pandemic COVID-19 period, uncertainty has increased and the food supply chain system has changed. Thus, a new configuration of the food supply network requires analysis. In this paper, the concept of RFH is introduced to connect producers in rural areas and customers in urban areas. This paper determines the location and capacity of RFHs, the food supply network, the sum of maximum food supplies, and minimum logistics cost. This is done via a Multi-Objective Many-to-Many Location-Routing Problem model. Furthermore, since the conditions of the COVID-19 pandemic is uncertain, robust optimization is employed to handle uncertainties. During the current pandemic, red zones are defined to indicate the severity of the pandemic in a region. In this paper, the numerical experiment is considered for three scenarios when a region is in large-scale social distancing, partial social distancing, or normal conditions. This social distancing situation is based on the defined red zones. The optimal food supply network is obtained for the three scenarios and the best scenario among the three is identified.The COVID-19 pandemic caused by SARS-CoV-2 has now emerged as a global health problem and is responsible for high mortality and morbidity. The SARS-CoV-2 main protease (Mpro) emerged as a promising drug target because of its essential role in the processing of polyproteins, which is translated from viral RNA. The present study reports a designed novel hybrid antiviral molecule (VTRRT-13.V2.1) against SARS-CoV2 main protease. A series of different combinations of hybrid antiviral were generated from nonspecific antiviral molecules currently used to control COVID-19. To enhance the specificity of the designed hybrid antiviral molecule, the core pocket region of the active site of Mpro protein was targeted. In-silico screening, molecular mechanics, molecular dynamics simulation (MDS) analysis identified a hybrid VTRRT-13.V2 molecule. Retrosynthetic analysis and combinatorial synthesis generated 1000 analogs of VTRRT-13.V2 molecules. Docking, molecular mechanics, and MDS analysis selected VTRRT-13.V2.1 as a possible inhibitor for SARS-CoV2 main protease.
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