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Power Polat posted an update 6 months, 3 weeks ago
Depression was not associated with BUP initiation.. Among BUP starters, depression vs. no depression, was significantly associated with receiving 29% fewer BUP prescriptions (RR=0.71; 95%CI 0.51-0.98) and an increased risk for > 30 day gap (HR=1.76; 95%CI1.01-3.09).
Missing data prevented measuring BUP dose.
Depression is likely associated with earlier BUP treatment dropout. Depression related medication non-adherence or possible worsening of depression following BUP taper could explain results. Research is needed to determine if depression severity is associated with BUP dose trajectories and multi-year BUP retention..
Depression is likely associated with earlier BUP treatment dropout. Depression related medication non-adherence or possible worsening of depression following BUP taper could explain results. this website Research is needed to determine if depression severity is associated with BUP dose trajectories and multi-year BUP retention..
Cardiovascular disease is disproportionally prevalent in bipolar disorder (BD) and has been linked to cognition in preliminary studies. Herein we evaluate the association between known risk factors for cardiovascular disease and executive function in BD patients compared to healthy controls.
In a sample of n=57 individuals (n=23 BD, n=34 controls) we assessed two subdomains of executive function; cognitive flexibility (using the Trail Making Test – Part B) and cognitive inhibition (using the Stroop Colour Word Interference Task). Cardiovascular risk was assessed by means of serum triglyceride levels, body mass index (BMI) and waist circumference, as well as dietary saturated fat intake and a sex-specific cumulative cardiovascular risk score calculated using the Framingham Heart Study method.
Patients with BD had higher BMI and waist circumference, with more BD patients categorized as having central obesity than controls. In the BD group only, higher triglyceride levels were associated with worse cognitive flexibility, and elevated cumulative cardiovascular disease risk was associated with worse cognitive inhibition. No correlations between cardiovascular risk factors and executive function were evident in the control group.
The study was limited by the small sample size and should be considered hypothesis-generating CONCLUSIONS The associations between triglyceride levels, cumulative cardiovascular disease risk and executive functioning evident in BD in this study preliminarily indicate the potential for mechanistic overlap of physical health and cognitive function in the disorder.
The study was limited by the small sample size and should be considered hypothesis-generating CONCLUSIONS The associations between triglyceride levels, cumulative cardiovascular disease risk and executive functioning evident in BD in this study preliminarily indicate the potential for mechanistic overlap of physical health and cognitive function in the disorder.
Ketamine appears to have a therapeutic role in certain mental disorders, most notably depression. However, the comparative performance of different formulations of ketamine is less clear.
This study aimed to assess the comparative efficacy and tolerability of racemic and esketamine for the treatment of unipolar and bipolar major depression.
Systematic review and meta-analysis.
We searched PubMed, MEDLINE, Embase, PsycINFO, the Cochrane Central Register of Controlled Clinical Trials, and the Cochrane Database of Systematic Reviews for relevant studies published since database inception and December 17, 2019.
We considered randomized controlled trials examining racemic or esketamine for the treatment of unipolar or bipolar major depression.
Primary outcomes were response and remission from depression, change in depression severity, suicidality, retention in treatment, drop-outs, and drop-outs due to adverse events.
Evidence from randomized controlled trials was synthesized as rate ratios (RRs) for treatment response, disorder remission, adverse events, and withdrawals and as standardized mean differences (SMDs) for change in symptoms, via random-effects meta-analyses.
24 trials representing 1877 participants were pooled. Racemic ketamine relative to esketamine demonstrated greater overall response (RR=3.01vs. RR=1.38) and remission rates (RR=3.70vs. RR=1.47), as well as lower dropouts (RR=0.76vs. RR=1.37).
Intravenous ketamine appears to be more efficacious than intranasal esketamine for the treatment of depression.
Intravenous ketamine appears to be more efficacious than intranasal esketamine for the treatment of depression.
It remains unclear whether muscle strength directly links with suicidal thoughts in adults. Given that suicidal ideation is tightly linked to depressive mood, this study sought to investigate the association between handgrip strength and suicidal ideation independent of depressive mood.
We performed a cross-sectional analysis of 14,325 adults from the Korean National Health and Nutrition Survey. Handgrip strength was measured by squeezing the handgrip dynamometer using the dominant hand. Suicidal ideation and depressive mood were assessed via the self-reported questionnaires. Logistic regression models were applied to calculate the odds ratio (OR) and 95% confidence interval (CI) for suicidal ideation per 1 kg increase in handgrip strength while adjusting for potential confounders.
The mean age of participants was 49.8 years, 44.7% of whom were male. Suicidal ideation was associated with elderly age, female sex, low socioeconomic status, unhealthy lifestyles, and more comorbid conditions. Depressive mood was similarly associated with each of these factors. Each 1 kg increase in handgrip strength reduced the odds of suicidal ideation in both sexes independent of depressive mood ; in subgroup analysis this association remained robust among elderly men .
Causality and the impact of unmeasured confounders were not addressed.
Low handgrip strength is associated with suicidal ideation among adults. Future research is required to confirm our findings and to establish whether strength training can reduce suicidal behaviors, particularly in elderly men.
Low handgrip strength is associated with suicidal ideation among adults. Future research is required to confirm our findings and to establish whether strength training can reduce suicidal behaviors, particularly in elderly men.