• Willard Barbee posted an update 6 months, 3 weeks ago

    in English, Spanish La artrosis de la muñeca es un proceso degenerativo, postraumático o idiopático que provoca al paciente dolor, pérdida de la movilidad, inflamación y deformidad. Batimastat Las opciones quirúrgicas incluyen artrodesis total de muñeca que produce una mejoría del dolor y disminución de la inflamación, otros tratamientos que permiten movilidad relativa son las artrodesis parciales. Otra solución quirúrgica es la carpectomía o la resección de la primera hilera del carpo, de tal manera que constituya una nueva articulación entre el radio y la segunda fila del carpo, obteniendo una congruencia articular adecuada. Material y métodos Estudio observacional, descriptivo, serie de casos. Se valoraron 15 pacientes con carpectomía proximal durante el período de Enero de 2007 a Agosto de 2009, a quienes se realizó medición de arcos de movilidad y fuerza mediante las escalas de Mayo-DASH. Resultados En 80% de los pacientes entre 35 y 64 años se encontró predominio del sexo masculino en 67%. La mejoría del dolor fue evidente, pasando de una media 7.7 en el preoperatorio a 2.7 en el postoperatorio, 10% de los casos presentaron dolor residual. Conclusiones La carpectomía proximal representa una alternativa terapéutica que permite conservar la movilidad con mejora del dolor en la artrosis de muñeca.No Abstract available.Retraction Note to J Zhejiang Univ-Sci B (Biomed & Biotechnol) 2019 20(11)877-890. https//doi.org/10.1631/jzus.B1800530. The authors have retracted this article (Zhao et al., 2019) due to significant overlap with a previously published Chinese language article (Liu et al., 2017), including overlap in Table 1, Table 2, Table 3, Table 6, Fig. 4, and part of the results (Sections 3.1, 3.2, 3.5, and 3.7). All authors agree with this retraction.Erratum to J Zhejiang Univ-Sci B (Biomed & Biotechnol) 2019 2019 20(10)816-827. https//doi.org/10.1631/jzus.B1900071. The original version of this article unfortunately contained a mistake. In p.823, Figs. 8c and 8d were in-correct, and the obvious pathological changes were mistakenly placed in the picture. The correct versions should be as follows.Combined radiation-wound injury (CRWI) is characterized by blood vessel damage and pro-inflammatory cytokine deficiency. Studies have identified that the direct application of leptin plays a significant role in angiogenesis and inflammation. We established a sustained and stable leptin expression system to study the mechanism. A lentivirus method was employed to explore the angiogenic potential and peripheral inflammation of irradiated human umbilical vein endothelial cells (HUVECs). Leptin was transfected into human placenta-derived mesenchymal stem cells (HPMSCs) with lentiviral vectors. HUVECs were irradiated by X-ray at a single dose of 20 Gy. Transwell migration assay was performed to assess the migration of irradiated HUVECs. Based on the Transwell systems, co-culture systems of HPMSCs and irradiated HUVECs were established. Cell proliferation was measured by cell counting kit-8 (CCK-8) assay. The secretion of pro-inflammatory cytokines (human granulocyte macrophage-colony stimulating factor (GM-CSF), if HUVECs after X-ray radiation.OBJECTIVE Drug-resistance and metastasis are major reasons for the high mortality of ovarian cancer (OC) patients. Cyclooxygenase-2 (COX-2) plays a critical role in OC development. This study was designed to evaluate the effects of COX-2 on migration and cisplatin (cis-dichloro diammine platinum, CDDP) resistance of OC cells and explore its related mechanisms. METHODS Cell counting kit-8 (CCK-8) assay was used to detect the cytotoxicity effects of celecoxib (CXB) and CDDP on SKOV3 and ES2 cells. The effect of COX-2 on migration was evaluated via the healing test. Western blot and real-time quantitative polymerase chain reaction (qPCR) were used to analyze E-cadherin, vimentin, Snail, and Slug levels. RESULTS COX-2 promoted drug-resistance and cell migration. CXB inhibited these effects. The combination of CDDP and CXB increased tumor cell sensitivity, reduced the amount of CDDP required, and shortened treatment administration time. COX-2 upregulation increased the expression of Snail and Slug, resulting in E-cadherin expression downregulation and vimentin upregulation. CONCLUSIONS COX-2 promotes cancer cell migration and CDDP resistance and may serve as a potential target for curing OC.To investigate associations between central visual function and inner retinal structure in primary open-angle glaucoma (POAG). This study enrolled 78 POAG patients and 58 healthy controls. POAG was classified into early glaucoma and moderate to advanced glaucoma. The following tests were performed on all participants isolated-check visual evoked potential (icVEP) testing, 24-2 standard automated perimetry (SAP), and Cirrus optical coherence tomography (OCT) examinations. Signal-to-noise ratio (SNR) measures obtained from icVEP responses to isolated checks presented at four depths of modulation (DOMs; 8%, 14%, 22%, and 32%) were explored. Mean macular sensitivity (mMS) was assessed by calculating the mean sensitivities of central 12 SAP points. Ganglion cell layer+ inner plexiform layer thickness (GCL+IPLT) and peripapillary retinal nerve fiber layer thickness (pRNFLT) were measured by OCT scanning. For each group of subjects, linear relationships among the following measures were analyzed SNR, mMS, GCL+IPLT, T. In early glaucoma, both SNR and mMS were related moderately and significantly to IRT, whereas in moderate to advanced glaucoma, mMS was more strongly correlated with IRT than SNR.OBJECTIVE To provide comprehensive data to understand mechanisms of vascular endothelial cell (VEC) response to hypoxia/re-oxygenation. METHODS Human umbilical vein endothelial cells (HUVECs) were employed to construct hypoxia/re-oxygenation-induced VEC transcriptome profiling. Cells incubated under 5% O2, 5% CO2, and 90% N2 for 3 h followed by 95% air and 5% CO2 for 1 h were used in the hypoxia/re-oxygenation group. Those incubated only under 95% air and 5% CO2 were used in the normoxia control group. RESULTS By using a well-established microarray chip consisting of 58 339 probes, the study identified 372 differentially expressed genes. While part of the genes are known to be VEC hypoxia/re-oxygenation-related, serving as a good control, a large number of genes related to VEC hypoxia/re-oxygenation were identified for the first time. Through bioinformatic analysis of these genes, we identified that multiple pathways were involved in the reaction. Subsequently, we applied real-time polymerase chain reaction (PCR) and western blot techniques to validate the microarray data.

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