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Napier Allred posted an update 6 months, 2 weeks ago
A P value ≤.05 and false discovery rate ≤0.01 were considered statistically significant.
We have confirmed that the predicted TFBSs in the HOX gene promoters function in transcriptional regulation by modulating target gene activity. TF-gene interactions are crucial to understanding oral carcinogenesis.
We have confirmed that the predicted TFBSs in the HOX gene promoters function in transcriptional regulation by modulating target gene activity. TF-gene interactions are crucial to understanding oral carcinogenesis.
Carotid body tumors (CBTs) are benign but challenging. This study compared outcomes of 3 techniques of the surgical treatment of CBTs.
This retrospective observational study was conducted from April 2013 to March 2019. The 38 patients enrolled in the study had primary tumors, including 1 with bilateral tumors and another with adrenal gland pheochromocytoma. We collected data on age, sex, size of tumor, Shamblin classification, treatment, blood loss, operative time, hospital stay, complications, and recurrence. Statistical analyses were performed using IBM SPSS Statistics version 20 software.
Twenty-four patients were male, and 12 were female, and they ranged in age from 11 to 71 years. Cases were assigned to Shamblin groups I (n=6), II (n=19), and III (n=14). Tumor size ranged from 2.0×2.0 cm to 5.0×6.0 cm. Eleven CBTs underwent blunt dissection (BD), 20 underwent BD plus resection of external carotid artery division plus vessels of encapsulation with allograft dermal matrix (BD+RECA+VE), and 8 tumors underwent surgical resection of tumors plus common carotid artery-internal carotid artery artificial vascular reconstruction (SR +C-IAVR). No perioperative death or stroke occurred. There was a significant difference between Shamblin groups I, II, and III in terms of the size of the tumor, type of treatment used, blood loss, operative time, hospital stay, and complications. Six patients had mandibular branch facial nerve transient paresis; 7 patients had hypoglossal nerve dysfunction; 3 patients had Horner syndrome; and dysphasia occurred in 2 patients. The patients were seen in follow-up for 16 to 45 months, and 1 recurrence was observed.
Three surgical techniques-BD, BD+RECA+VE, and SR+C-IAVR-are safe and feasible for the treatment of CBTs according to Shamblin classifications.
Three surgical techniques-BD, BD + RECA + VE, and SR + C-IAVR-are safe and feasible for the treatment of CBTs according to Shamblin classifications.
To assess setup reproducibility of low kneefix with feetfix (LKF-FF) system and its operator-reported convenience by reference to low dual leg positioner (LDLP), among patients treated with pelvic radiotherapy.
A retrospective controlled trial was carried out at the radiotherapy unit. It included patients who underwent radical radiotherapy to the pelvis using VMAT, and who benefitted from LDLP (N = 30) or LKF-FF (N = 30) immobilization system. Average absolute shifts (AAS) and total vector errors (TVE) were computed and compared between the two systems, using translational (lateral, longitudinal and vertical) and rotational (X, Y and Z planes) directions. Angiogenesis inhibitor Accuracy rates were computed on pooled data including 1529 VMAT images, 819 in LDLP and 710 in LKF-FF groups, using different cutoffs. Radiotherapists’ subjective assessment of the device’s ease of setup, handling, cleaning, and storage, and patient comfort was carried out comparatively between the two devices.
No statistically significant difference wed LKF-FF system outperformed LDLP in terms of setup reproducibility, notably in rotational directions, where it enhanced setup accuracy rates by up to 19%. Long-term use of LKF-FF may improve the users’ satisfaction.Diagnostic test accuracy studies are performed in order to determine the value of a diagnostic test. Primary studies of diagnostic accuracy describe the accuracy of a test calculated using the number of true and false positive and negative cases of a given diagnosis of interest. Systematic reviews of diagnostic test accuracy are performed to identify accuracy of a test but also to investigate where the test might sit in a diagnostic pathway or determine how different tests compare against each other. This introductory discussion paper aims to give the reader an overview of the various features in primary and secondary diagnostic test accuracy study designs for medical imaging professionals.Extracranial malignant rhabdoid tumors are rare and aggressive tumors that typically occur in the pediatric age group and have a poor prognosis. Herein, we report a case of a one year and five months old male infant who was referred with the diagnosis of malignant rhabdoid tumor of the liver. Magnetic resonance guided stereotactic body radiotherapy was administered with concomitant chemotherapy. Treatment was well tolerated with no severe acute side effects. A 40.8% volumetric reduction of the tumor was observed at the last fraction of MR guided radiotherapy. Résumé Les tumeurs rhabdoïdes malignes extracrâniennes sont des tumeurs rares et agressives qui surviennent généralement dans le groupe d’âge pédiatrique et dont le pronostic est mauvais. Nous rapportons ici le cas d’un enfant de sexe masculin d’un an et cinq mois qui a été référé avec le diagnostic de tumeur rhabdoïde maligne du foie. Une radiothérapie corporelle stéréotaxique guidée par résonance magnétique a été administrée avec une chimiothérapie concomitante. Le traitement a été bien toléré, sans effets secondaires aigus graves. Une réduction volumétrique de 40,8 % de la tumeur a été observée lors de la dernière fraction de la radiothérapie guidée par résonance magnétique.
Medication nonadherence is associated with more than $100 billion in preventable medical costs each year in the United States. Medication synchronization (med sync) programs have emerged as a potential solution to addressing nonadherence.
To assess the impact of med sync programs on adherence in adults on chronic medications through a meta-analysis.
A comprehensive literature search was conducted for studies of med sync and adherence in adults published in English from database inception to May 2020. Studies were included if they provided a description of the med sync program, reported a quantitative measure of medication adherence using the proportion of days covered metric, and were conducted in the United States. The search terms included “medication synchronization,” “med sync,” “adherence,” and “PDC.” Pooled odds ratios (ORs) and 95% CIs using random-effects models were calculated to assess overall impact and subgroup analyses. The risk of bias of individual studies was assessed using the Downs and Black checklist.