• Bradley Kjer posted an update 6 months, 2 weeks ago

    65), Wingate fatigue rate (r = -0.53), vertical jump (r = -0.52), and broad jump (r = -0.61), with resisted sprint tests showing the strongest associations (off-ice 15-kg resisted sprint (r = 0.79) and off-ice 30-kg resisted sprint (r = 0.74)). In multivariate analysis, stepwise regression revealed the 15-kg resisted sprint as the sole meaningful predictor of on-ice sprint time (R = 0.79, R = 0.62; p ≤ 0.001). We conclude that resisted off-ice sprints have better predictive ability of on-ice skate time compared with commonly used off-ice tests. Resisted sprinting can be used by strength and conditioning staff as an indicator of on-ice acceleration ability during periods of limited access to on-ice facilities or as a component of fitness testing.

    Astorino, TA, Oriente, C, Peterson, J, Alberto, G, Castillo, EE, Vasquez-Soto, U, Ibarra, E, Guise, V, Castaneda, I, Marroquin, JR, Dargis, R, and Thum, JS. Higher peak fat oxidation during rowing vs. read more cycling in active men and women. J Strength Cond Res 35(1) 9-15, 2021-This study compared fat and carbohydrate oxidation (CHOOx) between progressive rowing and cycling. Initially, 22 active healthy adults (age = 27 ± 8 years) performed incremental cycling and rowing to volitional fatigue to assess maximal oxygen uptake (V̇o2max) and maximal heart rate (HRmax). The order of 2 subsequent sessions was randomized, performed 2 hours postmeal, and included a warm-up followed by three 8-minute stages of rowing or cycling at 60-65, 70-75, and 80-85 %HRmax. During exercise, power output was modified to maintain work rate in the desired range. Gas exchange data and blood samples were obtained to measure fat and CHOOx and blood lactate concentration. Fat oxidation (FOx) increased during exercise (p < 0.001) and there on was lower (p = 0.007) at the end of rowing vs. cycling (3.1 ± 1.0 mM vs. 3.9 ± 1.6 mM, d = 1.1). Prolonged rowing having equivalent calorie expenditure and intensity vs. cycling elicits higher peak FOx, which is likely attributed to greater muscle mass used during rowing.Kipp, K, Kim, H, and Wolf, WI. Muscle-specific contributions to lower extremity net joint moments while squatting with different external loads. J Strength Cond Res XX(X) 000-000, 2020-The purpose of this study was to determine muscle-specific contributions to lower extremity net joint moments (NJMs) during squats with different external loads. Nine healthy subjects performed sets of the back squat exercise with 0, 25, 50, and 75% of body mass as an added external load. Motion capture and force plate data were used to calculate NJMs and to estimate individual muscle forces via static optimization. Individual muscle forces were multiplied by their respective moment arms to calculate the resulting muscle-specific joint moment. Statistical parametric mapping (α = 0.05) was used to determine load-dependent changes in the time series data of NJMs and muscle-specific joint moments. Hip, knee, and ankle NJMs all increased across each load condition. The joint extension moments created by the gluteus maximus and hamstring muscles at the hip, by the vastii muscles at the knee, and by the soleus at the ankle all increased across most load conditions. Concomitantly, the flexion moment created by the hamstring muscles at the knee also increased across most load conditions. However, the ratio between joint moments created by the vastii and hamstring muscles at the knee did not change across load. Similarly, the ratio between joint moments created by the gluteus maximus and hamstring muscles at the hip did not change across load. Collectively, the results highlight how individual muscles contribute to NJMs, identify which muscles contribute to load-dependent increases in NJMs, and suggest that joint moment production among synergistic and antagonistic muscles remains constant as external load increases.

    Foam cells are the main pathological components of atherosclerosis. Therapies reducing foam cell formation can effectively prevent atherosclerotic diseases and cardiovascular events. Beyond lowering plasma cholesterol levels, the pleiotropic functions of statins in atherosclerosis have not been fully elucidated. In the present study, atorvastatin reduced cholesterol content and increased cholesterol efflux from foam cells in a concentration-dependent manner. Atorvastatin (10 μM) inhibited foam cell formation within 48 hours. Furthermore, we found that atorvastatin inhibited foam cell formation by promoting lipophagy, which was manifested by increased autophagy-related gene 5 (Atg5) expression, elevated ratio of microtubule-associated protein1 light chain 3 (LC3) II to LC3I, reduced p62 expression, and increased LC3 and lipid droplets colocalization in foam cells treated with atorvastatin. The autophagy inducer, rapamycin (Rap), did not increase the lipophagy enhancement effect of atorvastatin, but the autopol efflux and increased cholesterol content in foam cells. Further analysis revealed that atorvastatin promoted lipophagy by upregulating adenosine 5′-monophosphate-activated protein kinase (AMPK) phosphorylation, and downregulating mammalian target of rapamycin phosphorylation, whereas the AMPK inhibiter, compound C, attenuated these effects. In conclusion, atorvastatin reduced lipid accumulation and promoted cholesterol efflux by enhancing lipophagy in foam cells and thereby inhibited foam cell formation. The enhanced lipophagy of foam cells was exerted through the AMPK/mammalian target of rapamycin signaling pathway.

    Atrial fibrillation (AF) is associated with an increased risk of dementia. Studies have shown the beneficial effects of anticoagulants in preventing dementia in this population. However, evidence around the use of direct oral anticoagulants (DOACs) versus warfarin in AF-related dementia prevention remains sparse. This systematic review and meta-analysis aimed to evaluate the use of DOACs versus warfarin in dementia prevention in this population. MEDLINE, EMBASE, PsycINFO, and the CENTRAL databases were systematically searched from its inception until May 2020. Nine studies (n = 611,069) were included for quantitative meta-analysis. DOACs use was associated with a lower risk of composite dementia outcomes compared with warfarin use . No significant difference was found in subtypes of dementia (vascular dementia, Alzheimer’s disease, and cognitive disorder) between both groups. No significant difference in the risk of composite dementia outcomes between the dabigatran and warfarin groups (OR 0.

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