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Aagesen Schack posted an update 6 months ago
Despite knowledge about eating disorder symptoms in children and adolescents in the general population, relatively little is known about self-reported and sex-specific eating-disorder-related psychopathology, as well as its specific correlates.
880 German school-attending adolescents (15.4±2.2 years) and 30 female patients with AN (16.2±1.6 years) were studied. All participants completed the Eating Disorder Inventory-2 and a Body Image Questionnaire.
There were more overweight males than females (15.2% vs 10.1%,
< 0.001), but more females with underweight than males (6.2% vs. 2.5%,
< .001). check details Negative body evaluations (
< .001) and dissatisfaction (p < .001) were significantly more frequent in females. Compared to underweight female patients with AN, underweight school-attending females had less negative body evaluations (
< .001) and lower scores on 5 of the 11 EDI-2 subscales (p < .001;
< .05).
Males were more overweight than females, females more underweight. Body image was more important to female than to male youth, yet without reaching pathological values when compared to female patients with AN. Complex emotional and cognitive challenges seem to be a representative factor for eating pathology rather than simply being underweight. These aspects may be relevant for the shift from a thinness-related focus in girls in the general population to the development of an eating disorder.
Males were more overweight than females, females more underweight. Body image was more important to female than to male youth, yet without reaching pathological values when compared to female patients with AN. Complex emotional and cognitive challenges seem to be a representative factor for eating pathology rather than simply being underweight. These aspects may be relevant for the shift from a thinness-related focus in girls in the general population to the development of an eating disorder.
Cytomegalovirus infection is thought to affect the immune system and to impact general health during ageing. Higher CMV-specific antibody levels in the elderly are generally assumed to reflect experienced viral reactivation during life. Furthermore, high levels of terminally differentiated and CMV-specific T cells are hallmarks of CMV infection, which are thought to expand over time, a process also referred to as memory inflation.
We studied CMV-specific antibody levels over ~27years in 268 individuals (aged 60-89years at study endpoint), and to link duration of CMV infection to T-cell numbers, CMV-specific T-cell functions, frailty and cardiovascular disease at study endpoint.
In our study, 136/268 individuals were long-term CMV seropositive and 19 seroconverted during follow-up (seroconversion rate 0.56%/year). CMV-specific antibody levels increased slightly over time. However, we did not find an association between duration of CMV infection and CMV-specific antibody levels at study endpoint. No clearimmunity is not evidently linked to frailty, it tends to associate with higher prevalence of cardiovascular disease.
Osteoarthritis (OA) is the most common form of arthritis characterised by cartilage degradation, synovitis and pain. Disease modifying treatments for OA are not available. The critical unmet need is to find therapeutic targets to reduce both disease progression and pain. The cytokine IL-33 and its receptor ST2 have been shown to play a role in immune and inflammatory diseases, but their role in osteoarthritis is unknown.
Non-OA and OA human chondrocytes samples were examined for IL-33 and ST2 expression. Novel inducible cartilage specific knockout mice (IL-33
) and inducible fibroblast-like synoviocyte knockout mice (IL-33
) were generated and subjected to an experimental OA model. In addition, wild-type mice were intra-articularly administered with either IL-33- or ST2-neutralising antibodies during experimental OA studies.
IL-33 and its receptor ST2 have increased expression in OA patients and a murine disease model. Administering recombinant IL-33 increased OA and pain
. Synovial fibroblast-specific deletion of IL-33 decreased synovitis but did not impact disease outcomes, whilst cartilage-specific deletion of IL-33 improved disease outcomes
. Blocking IL-33 signalling also reduced the release of cartilage-degrading enzymes in human and mouse chondrocytes. Most importantly, we show the use of monoclonal antibodies against IL-33 and ST2 attenuates both OA and pain
.
Overall, our data reveal blockade of IL-33 signalling as a viable therapeutic target for OA.
Overall, our data reveal blockade of IL-33 signalling as a viable therapeutic target for OA.There is increasing evidence from animal and human studies that glaucoma is an autoimmune disease. Evidence for this hypothesis includes the fact that antibodies as well as T-cell responses to heat-shock proteins (HSPs) are detectable in some patients with glaucoma and in an animal model of the disease. As in the human disease, experimental animal models of glaucoma have been found to demonstrate neurodegenerative changes in the optic nerve associated with immunoglobulin and T-cell infiltration. Although there is still insufficient evidence in humans to classify all cases of glaucoma as autoimmune diseases, the implications of this hypothesis have major impact on the diagnosis and treatment of glaucoma.The role of the selenoproteome, which is the collection of all proteins containing selenium in an organism, in cancer development, growth and progression requires further investigation, due to the importance of selenium in both cancer and immune system function. Data about the selenoproteome, including its differential expression, single nucleotide variations, copy number variations, methylation, pathways and overall survival (OS) in five leading types of cancer are available from the GSCALite website. Subsequent to the analysis of these datasets, it was revealed that there was increased expression of GPX3 in stomach adenocarcinoma and lung squamous cell carcinoma, SELENOV in oesophageal carcinoma, GPX8 and GPX4 in colon adenocarcinoma, TXNRD1 and SEPHS1 in hepatocellular carcinoma and GPX8 in lung adenocarcinoma were associated with poor survival. Decreased gene expression of SELENOP was indicated in liver hepatocellular carcinoma and GPX3, and SELENOW, SELENOK, SELENBP1 and SECISBP2 in lung adenocarcinoma were associated with a poor prognosis.
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