• Humphrey McNulty posted an update 6 months ago

    Asthma Severeness as well as Manage and Their Association With Perinatal Emotional Illness.

    The hospital admission rate is high in patients treated with peritoneal dialysis (PD), and the length of stay (LOS) in the hospital is a key indicator of medical resource allocation. This study aimed to develop a scoring tool for predicting prolonged LOS (pLOS) in PD patients by combining machine learning and traditional logistic regression (LR).

    This study was based on patient data collected using the Hospital Quality Monitoring System (HQMS) in China. Three machine learning methods, classification and regression tree (CART), random forest (RF), and gradient boosting decision tree (GBDT), were used to develop models to predict pLOS, which is longer than the average LOS, in PD patients. The model with the best prediction performance was used to identify predictive factors contributing to the outcome. A multivariate LR model based on the identified predictors was then built to derive the score assigned to each predictor. Finally, a scoring tool was developed, and it was tested by stratifying PD patients inool has a great potential to help physicians allocate medical resources optimally and achieve improved clinical outcomes.

    This study developed a scoring tool to predict pLOS in PD patients. The scoring tool can effectively discriminate patients with different pLOS risks and be easily implemented in clinical practice. The pLOS scoring tool has a great potential to help physicians allocate medical resources optimally and achieve improved clinical outcomes.

    Birt-Hogg-Dube (BHD) syndrome is an autosomal dominant disease that has been characterized by skin lesions, multiple pulmonary cysts, spontaneous pneumothorax, and renal tumors, but the patients in Asian countries may show fewer symptoms. We aimed to explore and summarize the clinical features of BHD patients in East Asia to facilitate early diagnosis and timely interventions.

    We collected and analyzed the clinical data of patients diagnosed with BHD in our hospital by reviewing medical records. We performed a systematic literature search regarding the presenting clinical features in BHD patients from China, Japan, and Korea and then reviewed the publications that were identified.

    In our hospital, 10 patients were diagnosed with BHD from April 2015 to September 2019. After reviewing the literature, we recruited 38 articles, including 12, 20, and 6 reports from China, Japan, and Korea, respectively. http://www.selleckchem.com/products/azd1390.html A total of 166 patients were included in this study, and 100 of them (60.2%) were females. Multiple pulmonommon symptom in East Asian patients with BHD, and that skin lesions and kidney involvement are less frequent. To make an early diagnosis and minimize the severity of complications, careful observation, and timely genetic examination of the FLCN gene is essential.

    A thin endometrium affects embryo implantation. We designed a retrospective cohort study to analyze the differences of

    fertilization-intracytoplasmic sperm injection (IVF-ICSI) outcomes between fresh embryo transfer (ET) and frozen ET in patients with a thin endometrium.

    The present study comprised of 1,110 patients with a thin endometrium undergoing IVF-ICSI between January 2013 and December 2017 in our unit. Propensity score matching (PSM) was used to balance the influence of intergroup confounding factors and to compare the pregnancy outcomes of the matched patients in the two groups. The fresh embryo group and frozen embryo group consisted of 632 and 478 women, respectively. After PSM, 173 patients were included in the two groups, respectively.

    The frozen embryo group showed a higher live birth rate (31%

    18.4%, P<0.001; 30.6%

    19.7%, P=0.019), clinical pregnancy rate (40%

    26.4%, P<0.001; 38.7%

    25.4%, P=0.008), and biochemical pregnancy rate (46.2%

    32.9%, P<0.001; 44.5%

    31.8%, P=0.020) than the fresh embryo group before and after PSM.

    Our results demonstrated that for women with a thin endometrium who were undergoing IVF, the live birth rate, clinical pregnancy rate, and biochemical pregnancy rate after frozen ET were significantly higher than in the fresh ET group.

    Our results demonstrated that for women with a thin endometrium who were undergoing IVF, the live birth rate, clinical pregnancy rate, and biochemical pregnancy rate after frozen ET were significantly higher than in the fresh ET group.

    The relationship between blood pressure (BP) control and the risk of new-onset hyperuricemia remains uncertain. We aimed to examine the association between degree of time-averaged on-treatment BP control and new-onset hyperuricemia in general hypertensive patients.

    A total of 10,617 hypertensive patients with normal uric acid (UA) concentrations (<357 µmol/L) at baseline were included from the UA Sub-study of the China Stroke Primary Prevention Trial (CSPPT). Participants were randomized to receive a double-blind daily treatment of enalapril 10 mg and folic acid 0.8 mg or enalapril 10 mg alone. BP measurements were taken every three months after randomization. The primary outcome was new-onset hyperuricemia, defined as a UA concentration ≥417 µmol/L in men or ≥357 µmol/L in women at the exit visit.

    Over a median of 4.4 years, 1,664 (15.7%) participants developed new-onset hyperuricemia. Overall, there was a significantly positive association between time-averaged on-treatment diastolic BP (DBP) and nh lower risk of new-onset hyperuricemia among hypertensive patients without hyperuricemia.

    To explore the efficacy of treatment strategies for non-metastatic gastric linitis plastica (GLP).

    Patients with non-metastatic GLP from 2004 to 2014 were identified from the National Cancer Database (NCDB). https://www.selleckchem.com/products/azd1390.html We compared overall survival (OS) of those patients who received different treatments, including surgery alone, a combination of surgery with chemotherapy and/or radiotherapy (S + C/R), chemotherapy and/or radiotherapy (C/R), and no treatment.

    The cohort included 474 patients with non-metastatic GLP. Overall, the median survival was significantly different among four groups (13.90 months in S + C/R, 8.38 months in surgery alone, 8.94 months in C/R and 2.50 months in no treatment). Then, we compared the efficacy of surgery alone and surgery with postoperative chemotherapy and/or radiotherapy (S + post C/R). When the tumor size was greater than 8 cm in stage III patients, S + post C/R was associated with a better survival benefit than surgery alone. S + post C/R also conferred an obvious survival advantage compared to surgery alone for R0 patients with positive lymph nodes and patients with positive margins.

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