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Bennett Grimes posted an update 6 months, 3 weeks ago
5% and 90% respectively. The therapeutic approach was modified in 50% of patients with locoregional lesions. Conclusions Our study confirmed that 18F-FDG-PET/CT is a useful tool for detecting locoregional recurrence in thyroid cancer patients with BIR or IR with conflicting findings in standard diagnostic procedures. Encorafenib chemical structure In 50% of patients with locoregional lesions, there was an immediate change in the treatment approach.Background Telehealth services are rapidly embraced in uro-oncology due to the current coronavirus disease 2019 (COVID-19) pandemic. Objective To determine patients’ perspective on adoption of telehealth as a response to the pandemic and its sustainability in the future. Design, setting, and participants Following a COVID-19 outbreak, 101 patients with advanced genitourinary cancers are currently managed “virtually” for therapy administration at our tertiary care unit. They were surveyed about the current situation, and current and long-term employment of telehealth. Intervention Rapid implementation of virtual patient management. Outcome measurements and statistical analysis Patients’ perception of anxiety of COVID-19 and cancer, perspective on telehealth measures as a reaction to the current COVID-19 pandemic, and long-term acceptance were used as outcomes. Wilcoxon matched-pair signed rank test, chi-square test, and Mann-Whitney U test were performed. Results and limitations Of 101 patients, 92 answered thilling to compromise on their treatment. Rapid implementation of telehealth is tolerated well during the need of social distancing, with a clear “red line” concerning changes in existing patient-physician relationships. Balancing future implementation of telehealth while considering patients’ demand for personal relationships will ensure human dignity in uro-oncology. Patient summary We queried patients with genitourinary cancers treated in an almost virtual setting following a local coronavirus outbreak. Acceptance of telehealth during the current situation is high; however, long-term implementation of the adapted services is less favored. We deduce that patient-physician relationship is crucial for cancer patients and needs to be balanced against measures for social distancing to forge the future management.Objectives Although a body of research has focused on violence, disruption, and harassment targeting abortion clinics and clinic staff, little research has explored Canadian abortion patients’ experiences with protesters. Through this national qualitative study we aimed to address this gap. Methods Between 2012 and 2016, we conducted in-depth interviews with 305 Canadian women who had an abortion in the previous five years. Thirty participants reported encountering protesters when seeking abortion care. We focused on this sub-set of interviews and analyzed these data for content and themes using inductive and deductive techniques. Results Across the country, participants reported encountering protesters holding signs, chanting slogans, and shouting insults. These interactions were concentrated at clinics in New Brunswick, Newfoundland and Labrador, and Ontario. Although no participants reported that these encounters made them reconsider their decision, they did report that seeing and interacting with protesteprove some patients’ experiences obtaining a medically necessary and essential service.Rationale and objectives To identify whether the radiomics features of computed tomography (CT) allowed for the preoperative discrimination of the invasiveness of lung adenocarcinomas manifesting as pure ground-glass nodules (pGGNs) and further to develop and compare different predictive models. Materials and methods We retrospectively included 187 lung adenocarcinomas presenting as pGGNs (66 preinvasive lesions and 121 invasive lesions), which were randomly divided into the training and test sets (82). Radiomics features were extracted from non-enhanced CT images. Clinical features, including patient’s demographic characteristics, smoking status, and conventional CT features that reflect tumor’s morphology and surrounding information were also collected. Intraclass correlation coefficient and ℓ2.1-norm minimization were used to identify influential feature subset which was then used to build three predictive models (clinical, radiomics, and clinical-radiomics models) with the gradient boosting regression tree classifier. The performances of the predictive models were evaluated using the area under the curve (AUC). Results Of the 1409 radiomics features and 27 clinical feature subtypes, 102 features were selected to construct the hybrid clinical-radiomics model, which achieved the best discriminative power (AUC = 0.934 and 0.929 in training and test set). The radiomics model showed comparable predictive performance (AUC = 0.911 and 0.901 in training and test set) compared to the clinical model (AUC = 0.911 and 0.894 in training and test set). Conclusion The radiomics model showed good predictive performance in discriminating invasive lesions from preinvasive lesions for lung adenocarcinomas presenting as pGGNs. Its performance can be further improved by adding clinical features.Rationale and objectives To establish a proof-of-principle for combined assessment of pulmonary ventilation and perfusion using single-energy computed tomography (CT) and image processing/analysis (denoted as single-energy CT ventilation/perfusion imaging). Materials and methods Breath-hold CT scans were acquired at end-expiration and end-inspiration before injection of iodinated contrast agents, and repeated at end-inspiration after contrast injection for 17 canines (8 normal and 9 diseased lung subjects). Ventilation images were calculated with deformable image registration to map the end-expiratory and end-inspiratory CT images and quantitative analysis for regional volume changes as surrogates for ventilation. Perfusion images were calculated by subtracting the end-inspiratory precontrast CT from the deformably registered end-inspiratory postcontrast CT, yielding a map of regional Hounsfield unit enhancement as a surrogate for perfusion. Ventilation-perfusion matching, spatial heterogeneity, and gravitationally directed gradients were compared between two groups using a Wilcoxon rank-sum test.
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