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Reeves Arsenault posted an update 6 months, 3 weeks ago
The collaboration between GI surgery and gastroenterologywith cTIF has led to an improved understanding in characteristicsof an optimal antireflux barrier andallowed for a proposed technical modification of the current fundoplication technique to optimize the construct of the surgical GEFV.
The collaboration between GI surgery and gastroenterology with cTIF has led to an improved understanding in characteristics of an optimal antireflux barrier and allowed for a proposed technical modification of the current fundoplication technique to optimize the construct of the surgical GEFV.
Although upper gastrointestinal (GI) neoplasms are not rare in patients with familial adenomatous polyposis (FAP), few studies have focused on them and the long-term outcomes of their treatment by endoscopy. Therefore, we aimed to investigate the prevalence and endoscopic treatment outcomes of upper GI neoplasms in patients with FAP.
Among 215 patients diagnosed with FAP between January 1991 and December 2019, 208 who underwent esophagogastroduodenoscopy were eligible. The clinical features and endoscopic treatment outcomes of upper GI neoplasms were retrospectively investigated and analyzed.
Among the enrolled patients, 113 (54.3%) had one or more upper GI neoplasms gastric adenoma (n = 34), gastric cancer (n = 7), nonampullary duodenal adenoma (n = 86), and ampullary adenoma (n = 53). Among patients with gastric neoplasms (n = 37), 24 (64.9%) underwent treatment (endoscopic treatment 22, surgery 2). No tumor-related mortality occurred during median follow-up of 106months (interquartile range 63-174). Endoscopic treatment was performed in 47 (54.7%) of 86 patients with nonampullary duodenal adenoma and in 32 (60.4%) of 53 patients with ampullary adenoma. No patient underwent surgery for duodenal neoplasms, and no tumor-related mortality occurred during median follow-up of 88months (IQR 42-145). The proportion of patients with increased Spigelman stage at 2years after the initial diagnosis or treatment was significantly higher in untreated group than in the group treated for duodenal neoplasms (27.3% vs. 0.0%, p = 0.001).
Endoscopic surveillance in FAP patients is important for the detection and treatment of upper GI neoplasms in early stage. In particular, endoscopic therapy for duodenal neoplasms can reduce the severity of duodenal polyposis.
Endoscopic surveillance in FAP patients is important for the detection and treatment of upper GI neoplasms in early stage. SQ22536 manufacturer In particular, endoscopic therapy for duodenal neoplasms can reduce the severity of duodenal polyposis.
MRI is a reliable and accurate technique to characterize rheumatoid arthritis. The aim of this study was to provide voxel-by-voxel 3D maps of the proton density fat fraction (PDFF), the T
of water (T
), the T
of fat (T
), the T
* of water (T
*
), the T
* of fat (T
*
) in the wrist bone marrow.
The experiments were conducted on 14 healthy volunteers (mean age 24 ± 4). The data were acquired at 1.5 T using two optimized four-echo 3D 1.2 × 1.2 × 1.2mm
-isotropic spoiled gradient sequences. A repeatability study was carried out. The measurements were done using a homemade parametric viewer software.
The inter-volunteer results were, on average PDFF = 86 ± 3%, T
= 441 ± 113ms, T
= 245 ± 19ms, T
*
= 6 ± 1ms and T
*
= 16 ± 3ms. The coefficients of variation were for fat based biomarkers CV
< 5%, CV
< 15% and CV
< 10% in the repeatability study.
The protocol and quantification tool proposed in this study provide high-resolution voxel-by-voxel 3D maps of five biomarkers in the wrist in less than 4min of acquisition.
The protocol and quantification tool proposed in this study provide high-resolution voxel-by-voxel 3D maps of five biomarkers in the wrist in less than 4 min of acquisition.
To investigate whether varied or repeated b-values provide better diffusion MRI data for discriminating cortical areas with a data-driven approach.
Data were acquired from three volunteers at 1.5T with b-values of 800, 1400, 2000s/mm
along 64 diffusion-encoding directions. The diffusion signal was sampled from gray matter in seven regions of interest (ROIs). Rotational invariants of the local diffusion profile were extracted as features that characterize local tissue properties. Random forest classification experiments assessed whether classification accuracy improved when data with multiple b-values were used over repeated acquisition of the same (1400s/mm
) b-value to compare all possible pairs of the seven ROIs. Three data sets from the Human Connectome Project were subjected to similar processing and analysis pipelines in eight ROIs.
Three different b-values showed an average improvement in correct classification rates of 5.6% and 4.6%, respectively, in the local and HCP data over repeated measurements of the same b-value. The improvement in correct classification rate reached as high as 16% for individual binary classification experiments between two ROIs. Often using only two of the available three b-values were adequate to make such an improvement in classification rates.
Acquisitions with varying b-values are more suitable for discriminating cortical areas.
Acquisitions with varying b-values are more suitable for discriminating cortical areas.Strength-based approaches to youth development have been tested in community settings and are related to improvements in social, health, and academic realms. However, little is known about similar approaches to enhance parent-teen communication (PTC) in pediatric primary care. The goal of this study was to test the feasibility and acceptability of an intervention to facilitate parent-teen communication about teen strengths. Intervention materials were developed based on a literature review, expert consultation, and feedback from stakeholders. The final intervention was a parent-directed booklet and a parent-teen discussion activity. At the well-adolescent visit (WAV), dyads received an orientation to the materials and were instructed to complete the discussion activity within 2 weeks of the WAV. Health Care Providers verbally endorsed the materials and instructed parents to read the booklet and complete the discussion activity with their teens. Acceptability was assessed at 2-week and 2-month follow-ups. Parent-adolescent dyads from an urban, pediatric primary care practice were enrolled with half assigned to the treatment group.
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