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Groth Mosegaard posted an update 6 months, 2 weeks ago
This study was the first to evaluate the possible protective effects of cinnamic acid (CA) against Gentamicin (GM) induced liver and kidney dysfunctions in rats. Adult male Wistar rats were randomly assigned to 4 equal groups (n = 8) Control group (saline, 0.5 ml/day), CA group (CA, 50 mg/kg/day), GM group (GM, 100 mg/kg/day), and GM + CA group (100 & 50 mg/kg/day). Following 12 days of treatments, blood and 24 h urine samples were collected and kidneys were taken out for biochemical, histopathological, and molecular studies. Following CA treatment, renal function markers and transaminases activities including serum urea (59.92%) and creatinine (50.41%), protein excretion rate (43.67%), and serum activities of aspartate aminotransferase (AST) (54.34%) and alanine aminotransferase (ALT) (47.26%) significantly reduced in the treated group as compared with the GM group (P less then 0.05). Also, CA could significantly ameliorate the levels of triglyceride (29.70%), cholesterol (13.02%), very low-density lipoprotein (29.69%) and high-density lipoprotein-cholesterol (7.28%). CA could also attenuate oxidative stress through a decrease of serum malondialdehyde (MDA) (50.86%) and nitric oxide (NO) (0.85%) and an increase of renal catalase (CAT) (196.14%) and glutathione peroxidase (GPX) activities (45.88%) as well as GPX mRNA expression (44.42-fold) as compared with the GM group (P less then 0.05). Moreover, histopathological evaluations revealed attenuated tubular damages and reduced inflammatory cellular infiltration in CA treated animals. Overall, CA alleviates GM-induced nephrotoxicity and alterations in transaminases activities in rats through its antioxidant activities.Aloe vera had been used for numerous medical and cosmetic applications since ancient times. The study aimed to investigate the integrated effects of inorganic fertilizer (IF) and poultry manure (PM) on the nutritional and pharmaceutical constituents of A. vera. check details Eighteen month old A. vera seedlings were used following completely randomized design with three replications. Six combinations of IF and PM (at the rate of 5 t ha-1) were considered viz., IF00PM00 (IF = 0%, PM = 0%), IF100PM00(IF = 100%, PM = 0%), IF75PM25 (IF = 75%, PM = 25%), IF50PM50 (IF = 50%, PM = 50%), IF25PM75 (IF = 25%, PM = 75%) and IF00PM100 (IF = 0%, PM = 100%) as treatments. Different treatment combinations of IF and PM exerted significant influence on the nutritional and pharmaceutical contents of A. vera. Concentrations and uptake of the concerned nutrients were gradually increased with the increased levels of PM except NPKS which were highest in sole application of IF. The aloin concentration of leaf was gradually increased with the increased level of PM and by 42.44% over control. The highest chlorophyll, total phenolic and flavonoid concentrations were found in the plants receiving the treatment IF25PM75 except protein content which was obtained from IF100PM00. Significant and positive relationships between N and S with P concentrations and P and S with K concentrations of A. vera leaf were noticed. Aloin, total phenolic and flavonoid concentrations were significantly and positively correlated with Mg, Fe and Mn concentrations of A. vera leaf. Farmers may be advised to cultivate A. vera applying 75% PM at the rate of 5 t ha-1 along with 25% IF (N, P, K and S at the rate of 150, 80, 120 and 30 kg ha-1, respectively) for obtaining better quality leaf in terms of nutrients and pharmaceutical compounds under the agro-climatic conditions of the study area.Octalithium tin (IV) oxide (Li8SnO6) is an important electrode material considered for lithium ion batteries (LIBs) because of its high lithium content. We employed atomistic simulations to examine the intrinsic defects, diffusion of Li-ions together with their migration energies and solution of potential dopants in Li8SnO6. The most thermodynamically favourable intrinsic defect is the Li Frenkel which increases the concentration of Li vacancies needed for the vacancy mediated diffusion of Li-ions in Li8SnO6. The calculated activation energy of migration of Li-ions (0.21eV) shows that the Li-ion conductivity in this material can be very fast. Promising isovalent dopants on the Li and Sn sites are Na and Ti, respectively. Doping of Ga on the Sn site can facilitate the formation of Li interstitials as well as oxygen vacancies in Li8SnO6. While the concentration of Li interstitials can enhance the capacity of this material, oxygen vacancies together with Li interstitials can lead to the loss of Li2O in Li8SnO6.The study analyzed the level of agro-ecosystem sensitivity to climate change among the agro-climatic zones (ACZs) that are situated in the highlands of Lake Tana sub-basin. The analyses considered the actual land capability class (LCC in % considering soil texture, slope and elevation zone), crop diversity (count), length of growing period (LGP, month), and inter-annual variability of climate (mean annual rainfall-MARF in mm, mean monthly minimum temperature-MMMinT in ºC, and mean monthly maximum temperature-MMMaxT in ºC). For comparison purpose, it was essential to index/standardize the values of specified indicators. The proportion of arable land varied from 13.30% (in the Sub-Alpine) to 93.00% (in the Moist-Cold). The value of coefficient of variation showed the presence of variations of 7.85-11.21 (%), 7.21-10.34 (%), 16.37-39.61 (%) for MARF (mm), MMMaxT (ºC), and MMMinT (ºC), respectively across the ACZs. The inter-annual variability of both onset and offset time of rainy season was found to be in the range of 0.3-1.25 months. The LGP (month) was in the range of 3.25-6.25 across the ACZs; whereas crop diversity (count) ranged from 2-7. The production of red onion (allium cepa), oat (Avena sativa), local wheat (Triticum), and pea (Pisum sativum) was abandoned in the Sub-Alpine; whereas the production of linseed (Linmu usitatisimum), barley (Hordeum vulgare), and niger (Guizotia abyssinica) in the Moist-Cool. Yet, crops like maize and tef became the common crops in the Cold, possibly because of global warming. The indexed value of agro-ecosystem sensitivity to climate change ranged from 0.14-0.71. The level of agro-ecosystem sensitivity was higher towards the Sub-Alpine. The local development interventions to be made in the various ACZs need to be determined/prioritized considering the level of agro-ecosystem sensitivity.