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Josephsen Estes posted an update 6 months, 1 week ago
Stroke can lead to disruption of the whole-brain network in patients. Acupuncture can modulate the functional network on a large-scale level in healthy individuals. However, whether and how acupuncture can make a potential impact on the disrupted whole-brain network after ischemic stroke remains elusive.
26 stroke patients with a right hemispheric subcortical infarct were recruited. We gathered the functional magnetic resonance imaging (fMRI) from patients with stroke and healthy controls in the resting state and after acupuncture intervention, to investigate the instant alterations of the large-scale functional networks. The graph theory analysis was applied using the GRETNA and SPM12 software to construct the whole-brain network and yield the small-world parameters and network efficiency.
Compared with the healthy subjects, the stroke patients had a decreased normalized small-worldness (
), global efficiency (
), and the mean local efficiency (
) of the whole-brain network in the resting state.stroke brain networks involving acupuncture intervention from a large-scale perspective.In this paper, a novel coronavirus infection system with a fuzzy fractional differential equation defined in Caputo’s sense is developed. By using the fuzzy Laplace method coupled with Adomian decomposition transform, numerical results are obtained for better understanding of the dynamical structures of the physical behavior of COVID-19. Such behavior on the general properties of RNA in COVID-19 is also investigated for the governing model. The results demonstrate the efficiency of the proposed approach to address the uncertainty condition in the pandemic situation.A stochastic SIR system with Lévy jumps and distributed delay is developed and employed to study the combined effects of Markovian switching and media coverage on stochastic epidemiological dynamics and outcomes. Stochastic Lyapunov functions are used to prove the existence of a stationary distribution to the positive solution. Sufficient conditions for persistence in mean and the extinction of an infectious disease are also shown.
South American rattlesnakes are represented in Brazil by a single species,
, which has public health importance due to the severity of its envenomation and to its wide geographical distribution. The species is subdivided into several subspecies, but the current classification is controversial. In Brazil, the venoms of
and
are used for hyperimmunization of horses for antivenom production, even though the distinction of these two subspecies are mostly by their geographical distribution. In this context, we described a comparative compositional and functional characterization of individual
and
venoms from three Brazilian states.
We compared the compositional patterns of
and
individual venoms by 1-DE and RP-HPLC. For functional analyzes, the enzymatic activities of PLA
, LAAO, and coagulant activity were evaluated. Finally, the immunorecognition of venom toxins by the crotalic antivenom produced at Butantan Institute was evaluated using Western blotting.
The protein profile of individuadless of the subspecies, as evidenced by PLA2 isoforms complexity, which may explain the increase in venom neurotoxicity from Northeastern through Southern Brazil reported for the species.
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. Previous observational studies suggested that cannabis use may be associated with a lower risk for NAFLD but the causal relationship remains unclear. G Protein antagonist We aim in this study to examine the causal effect of cannabis consumption on the risk of NAFLD using a Mendelian randomization analysis. Clarifying this causal effect is important for cannabis-based drug discovery for NAFLD.
We used data from the largest-to-date GWAS meta-analysis on lifetime use of cannabis (yes or no) consisting of three cohorts of European ancestry (total
= 184,765). We also used other GWAS data on cannabis use dependence and cannabis use disorder (CUD). The NAFLD GWAS data were generated from the UK Biobank population (1,122 cases and 399,900 controls). The inverse variance weighted (IVW) method was used to assess the causal impact of cannabis lifetime use on the risk of NAFLD. We also performed a sensitivity analysis using weighted median estimator and MR-Egger.
There was no statistically significant causal effect between either the lifetime cannabis use, cannabis use dependence or CUD and the risk for NAFLD (
> 0.05 for all tests). No significant pleotropic effect was observed based on both MR-PRESSO global test (
= 0.99) and the modified Q’ statistics. However, the study may be underpowered.
Our results demonstrated no evidence that cannabis consumption has a causal effect of protection against the development of NAFLD.
Our results demonstrated no evidence that cannabis consumption has a causal effect of protection against the development of NAFLD.Immune checkpoint inhibitors (ICIs) have shown promising results in bladder cancer (BC). However, only some patients respond to ICIs. DNA repair defects (DDR) play an important role in the therapeutic response of bladder cancer. Therefore, we aimed to elucidate the association between ICIs in bladder cancer and ataxia telangiectasia mutated (ATM), a core component of the DNA repair system. From a collected immunotherapy cohort (n = 210) and The Cancer Genome Atlas (TCGA)-Bladder cancer cohort, which were both retrieved from publicly available resources, we performed a series of analyses to evaluate the prognostic value and potential mechanism of ATM in bladder cancer immunotherapy. We found that ATM-mutant (ATM-MT) bladder cancer patients derived greater benefit from ICIs , P = 0.007] and showed a higher mutation load (P 1, P less then 0.05), while insulin-like growth factor receptor signaling pathways and vasculogenesis were significantly downregulated (NES less then -1, P less then 0.05). ATM mutation significantly upregulated the number of DNA damage repair pathway gene mutations (P less then 0.05). ATM mutations resulted in increased bladder cancer sensitivity to 29 drugs (P less then 0.05), including cisplatin and BMS-536924, an IGF-1R inhibitor. Our results demonstrate the importance of ATM as a prognostic signature in bladder cancer and reveal that ATM may impact the effects of ICIs by acting on the tumor immune microenvironment.
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