• Becker Mosegaard posted an update 6 months ago

    al toxicity. Consistent gaps in support highlight that strategies to mitigate financial effects related to travel, accommodation, medications, family support, and income replacement are needed for many patients and families even in the context of publicly funded healthcare systems.

    Survivors need to be informed early in their cancer experience about the potential financial burden associated with cancer treatment and its impact on survivors and their family members.

    Survivors need to be informed early in their cancer experience about the potential financial burden associated with cancer treatment and its impact on survivors and their family members.

    Women living with metastatic breast cancer (MBC) face significant distress and unmet needs, yet few resources have been developed for this population. The current study aimed to develop and evaluate the usability of Finding My Way-Advanced (FMW-A), a web-based self-guided psychosocial program for women with MBC.

    FMW-A was co-designed through (a) adapting an efficacious online program for people with curatively treated cancer and (b) receiving iterative rounds of input and feedback from a multidisciplinary co-design team including consumers, clinicians, and academics. A think-aloud protocol was then implemented to test the usability of the resulting 6-module prototype, with women living with MBC accessing up to three modules with an interviewer sitting along-side. Participants were recruited until saturation of themes occurred. Data were analysed thematically.

    Participants (n=8) were, on average, 65.3 years old, mostly partnered (n=5), retired (n=6), post-secondary school educated (n=6), and with non-dependent children (n=7). Feedback fell into 6 themes. Positive feedback about FMW-A summarised the supportive and informative nature of the program, supplemented by comments about broadly relatable content. However, one size clearly did not fit all within themes, diverging experiences emerged regarding navigability, worksheets, and layout. Participants noted that having/making time for the intervention would be important to program engagement.

    Usability testing indicated participants found content helpful and relatable, and identified significant pragmatic improvements to be made prior to further testing.

    The development of FMW-A represents an important step in providing acceptable resources to support women living with MBC.

    The development of FMW-A represents an important step in providing acceptable resources to support women living with MBC.

    The aim of the study was to examine the associations between personality, weight loss and obesity-related well-being post-bariatric surgery. It was hypothesised that persons who had undergone bariatric surgery who exhibit Extraversion, Conscientiousness, Agreeableness and Intellect/Imagination will have greater obesity-related well-being; whereas, those low on Emotional stability will have poorer obesity well-being.

    The cross-sectional sample comprised 127 females who had received bariatric surgery. The average age of participants was 45years. Quality of life was measured using the Obesity-Related Well-Being scale (ORWELL 97). Personality was assessed with the International Personality Item Pool (IPIP) 50-item measure of the Five-Factor Model.

    The mean BMI for the sample was 34.13 (SD = 7.8). Females with a larger BMI who had undergone bariatric surgery had lower obesity-related well-being. Conscientiousness was negatively associated with BMI. Separate Hierarchical regression analyses found that Emotional stability (Beta =  - .43,  - .47,  - .36) and Agreeableness (Beta = .27, .29, .25) predicted overall well-being, symptom occurrence and subjective relevance of distress, respectively. BMI predicted occurrence of symptoms (Beta = .23).

    The findings have implications for the development of personality-informed interventions for bariatric patients in enhancing well-being and weight-loss maintenance following surgery.

    Level III Evidence obtained from well-designed cohort or case-control analytic studies.

    Level III Evidence obtained from well-designed cohort or case-control analytic studies.

    The aims of this study were to develop an experimental procedure for setting the catheter angle with respect to the surface of the heart muscle and the catheter contact force and to investigate the catheter contact area on the heart muscle as a function of catheter contact angle and force.

    Visualization tests were performed for 5 contact angles (0°, 30°, 45°, 60°, and 90°) and 8 contact forces (2, 4, 6, 10, 15, 20, 30, and 40 gf). Each experiment was repeated 6 times with 2 different commercially available catheter tips.

    The morphology of the contact area was classified into rectangular, circular, ellipsoidal, and semi-ellipsoidal. The correlation between contact force and contact area was a logarithmic function; increasing contact force was associated with increased contact area. At the same contact force, the correlation between contact angle and contact area was inverse; decreasing contact angle was associated with a corresponding increase in contact area.

    Both the catheter contact angle and contact force substantially impact the contact area and morphology in catheter ablation procedures.

    Both the catheter contact angle and contact force substantially impact the contact area and morphology in catheter ablation procedures.The objective of this study was to evaluate antimicrobial therapy outcomes of bone and joint infections (BJI) caused by Clostridium perfringens. We investigated remission of symptoms and the absence of relapse or reinfection during follow-up. Among the 8 patients with C. perfringens BJI, the type of infection was early prosthesis infection (n = 2), osteosynthetic device infection (n = 4), and chronic osteomyeletis (n = 2). selleck compound Clindamycin-rifampicin combination was given in 4 cases and metronidazole in 4 cases. The overall success rate was 87.5%. Among the 7 patients who completed antibiotic treatment, the success rate was 100%. The clindamycin-rifampicin combination appeared to be effective in patients with C. perfringens BJI.

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