• Odgaard Hammer posted an update a month ago

    Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Although synthetic materials have been used in film coating processes for drug delivery for many years, substantial studies on natural materials have also been conducted because of their biodegradable and unique properties. check details Because of the ability to form and modify films for controlled oral drug delivery, increasing attention has been shown to these materials in the design of film coating systems in recent research. This review aims to provide an overview of natural materials focusing on film coating for oral delivery, specifically in terms of their classification, and their combinations in film coating formulations for adjusting the desired properties for controlled drug delivery. Discussing natural materials and their potential applications in film coating would benefit the optimization of processes and strategies for future utilization. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Poly (ADP-ribose) polymerase (PARP) acts as an essential DNA repair enzyme. PARP inhibitors are a novel small molecule targeted drugs based on the principle of ‘Synthetic Lethality”, which affect the DNA repair process by competitively inhibiting the activity of the PARP enzyme and thereby kill cancer cells. Currently, four PARP inhibitors including olaparib, rucaparib, niraparib, and talazoparib have been approved by FDA for cancer treatment and have achieved great success in the treatment of ovarian cancer, breast cancer, and pancreatic cancer etc. This paper provides a general overview of the research progress of PARP inhibitors including the major structure types, structure-activity relationship (SAR), and synthetic routes, with the aim of providing ideas for the discovery and synthesis of novel PARP inhibitors. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.(Proteolysis targeting chimera) degraders based on protein knockdown technology now are suggested as a novel option for the treatment of various diseases. Over the last couple of years, application of PROTAC technology has spread in a wide range of disorders, and plenty of PROTAC molecules with high potency have been reported. Mostly developing for anticancer therapy, these molecules show high selectivity to target proteins, ability to significantly induce degradation of oncoproteins, good in vivo and in vitro results. In this review, we summarized the recent development of PROTAC technology in the anticancer therapy field, including molecular design, types of targeted proteins, in vivo and in vitro data results. Additionally, we also discuss on the prospects and challenges for application of candidates based on PROTAC strategy in clinical trials. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.BACKGROUND Radionuclide molecular imaging of gastrin-releasing peptide receptor (GRPR) expression promises unparalleled opportunities for visualizing subtle prostate tumors, which due to small size, adjacent benign tissue, or a challenging location would otherwise remain undetected by conventional imaging. Achieving high imaging contrast is essential for this purpose and the molecular design of any probe for molecular imaging of prostate cancer should be aimed at obtaining as high tumor-to-organ ratios as possible. OBJECTIVE This short review summarizes the key imaging modalities currently used in prostate cancer, with a special focus on radionuclide molecular imaging. Emphasis is laid mainly on the issue of radiometals labeling chemistry and its influence on the targeting properties and biodistribution of radiolabeled GRPR antagonists for imaging of disseminated prostate cancer. METHODS A comprehensive literature search of the PubMed/MEDLINE, and Scopus library databases was conducted to find relevant articles. RESULTS The combination of radionuclide, chelator and required labeling chemistry was shown to have a significant influence on the stability, binding affinity, and internalization rate, off-target interaction with normal tissues and blood proteins, interaction with enzymes, activity uptake and retention in excretory organs and activity uptake in tumors of radiolabeled bombesin antagonistic analogues. CONCLUSION Labeling chemistry had a very strong impact on the biodistribution profile of GRPR-targeting peptide based imaging probes and needs to be considered when designing a targeting probe for high contrast molecular imaging. Taking into account the complexity of in vivo interactions, it is not currently possible to accurately predict the optimal labeling approach. Therefore, a detailed characterization and optimization is essential for the rational design of imaging agents. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Alzheimer‘s disease (AD) is a neurodegenerative disorder that has affected millions of people worldwide. However, currently there is no treatment to cure the disease. The AD drugs available in the market only manage the disease symptomatically and the effects are usually short-term. Thus, there is a need to look at alternatives AD therapies. Mid-life hypertension has not only been recognised as a risk factor for AD, but its relation with AD has also been well established. Thus, antihypertensives are postulated to be beneficial in managing AD. This literature review aims to shed some light on the potential of repurposing antihypertensives to treat AD, considering recent updates. Four classes of antihypertensives, as well as their potential limitations and future prospects in being utilised as AD therapeutics are discussed in this review. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Humans in hot environments are exposed to health risks and thermal discomfort which seriously affects their physical, physiological and mental workload. This study aimed to assess the effects of using cooling vests (CVs) on physiological and perceptual responses at workplace. Three main databases were searched using subject headings and appropriate Mesh terms. The article has been written according to the PRISMA checklist. A total of 23,837 studies were identified for screening and 63 studies were eligible for data extraction. A statistically significant difference was observed in body temperature among hybrid cooling garments (HBCGs), phase-change materials (PCMs) and air-cooled garments (ACGs)) at 31.56-37 °C (60% RH), evaporative cooling garments (ECGs) at 25.8-28.1 °C, and liquid cooling garments (LCGs) at 35 °C (49% RH) compared without cooling vests (CON) condition (p less then .001). HBCGs ((PCMs) and (ACGs)) are effective means in hot, moderate, humid or dry environments.

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