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Porterfield Busk posted an update 6 months, 2 weeks ago
RESULTS The variant in 5-HTTLPR was significantly associated with hoarding alone in males (p-value of 0.009). There were no significant findings for 5-HTTLPR in females. There were no significant findings after correction for multiple comparisons using SNP array data, but top SNP findings suggested that variation downstream of HTR1B may be implicated in hoarding alone in females. CONCLUSIONS Our results suggest specific serotonin gene variants are associated with hoarding traits alone, differing between sexes. Top findings are in line with our former study, suggesting that individuals with hoarding alone were driving previous results. Our paper supports hoarding disorder’s new designation. © 2020 Wiley Periodicals, Inc.AIM AND OBJECTIVES To compare the self-reported level of professionalism among nurses in Poland and Belarus and to indicate the areas in which differences in professional behaviours of nurses in both countries exist. BACKGROUND Nurses constitute the largest group of healthcare providers, and the term professionalism is closely related to nursing profession. DESIGN This investigation is a comparative survey and descriptive analysis of professional behaviours among nurses in Poland (n = 205) and Belarus (n = 236). The study was reported according to the STROBE checklist. HDAC inhibitor METHODS The Professionalism in Nursing Behaviors’ Inventory Image Survey adapted from Adams and Miller (2001) was used to collect the data. The questionnaire contains 46 questions addressing the following behavioural categories educational preparation, publications, research, professional organisation, community service, competence, code for nurses, theory and autonomy. RESULTS The mean total score of professionalism was significantly different between the two countries (p less then .0001). Significant differences, with higher scores in the group of respondents from Belarus, were also revealed in the following subscales of professionalism “Professional organisation,” “Community service,” “Competence” and “Publication.” Nurses from Poland had higher levels of “Educational preparation” and “Use of theory.” No statistically significant differences were indicated in the “Autonomy” and “Research” subscales. CONCLUSION Differences in the professionalism level of nurse practitioners in Poland and Belarus are related to nurses’ professional position and the context in which they practice. RELEVANCE TO CLINICAL PRACTICE The results of the present study can help the healthcare management and nursing leaders to support the professional development of nurses and strive for a higher level of professionalism. © 2020 John Wiley & Sons Ltd.Multi-photochromic systems incorporating individually addressable switching units are attractive for development of advanced data storage devices. Here we present the synthesis and properties of a selection of such molecular systems incorporating the dihydroazulene/vinylheptafulvene (DHA/VHF) photo-/thermo-switch. The influence of the linker ( meta -phenylene vs azulene-1,3-diyl vs thiophene-2,5-diyl) separating two DHA units on the switching properties was investigated. An azulene-1,3-diyl spacer largely inhibited both the DHA-to-VHF photoisomerizations and the thermal VHF-to-DHA back-reactions; the latter occurred 10 times slower than for the related compound with a meta -phenylene spacer. A DHA trimer containing three DHA units around a central benzene ring was found to undergo stepwise DHA-to-VHF photoisomerizations, while the thermal back-reactions occurred at similar rates for the three VHF entities. A meta -phenylene bridged DHA dimer was subjected to further structural modifications at position C-1 of each DHA, having strong implications for the switching events, and synthetic steps for further functionalizations at position C-7 of each DHA were investigated. Finally, the molecular structure (from X-ray crystallographic analysis) between the meta- phenylene bridged DHA dimer and Cu(I) is presented. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.NEW FINDINGS What is the central question of the study? What are the effects of caffeine on neuromuscular function in a non-fatigued state and during fatiguing exercise? What is the main finding and its importance? In a non-fatigued state, caffeine decreased the duration of the silent period evoked by transcranial magnetic stimulation. Caffeine-induced reduction of inhibitory mechanisms in the central nervous system before exercise was associated with an increased performance. Individuals who benefit from caffeine ingestion may experience lower perception of effort during exercise and an accelerated recovery of M-wave amplitude postfatigue. This study elucidates the mechanisms of action of caffeine and demonstrates that inter-individual variability of its effects on neuromuscular function is a fruitful area for further work. ABSTRACT Caffeine enhances exercise performance, but its mechanisms of action remain unclear. In this study, we investigated its effects on neuromuscular function in a non-fatigued state d decrease in SP and short-interval intracortical inhibition before the fatiguing activity was associated with an increased time to task failure. The participants who benefitted from an improved performance on the caffeine day reported a significantly lower sense of effort during exercise and had an accelerated postexercise recovery of M-wave amplitude. Caffeine modulates inhibitory mechanisms of the CNS, recovery of M-wave amplitude and perception of effort. This study lays the groundwork for future examinations of differences in caffeine-induced neuromuscular changes between those who are deemed to benefit from caffeine ingestion and those who are not. © 2020 The Authors. Experimental Physiology © 2020 The Physiological Society.The addition of stimuli-responsiveness to anti-Stokes emission provides a unique platform for biosensing and chemosensing. Particularly, stimuli-responsive photon upconversion based on triplet-triplet annihilation (TTA-UC) is promising due to its occurrence at low excitation intensity with high efficiency. This Minireview summarizes the recent developments of TTA-UC switching by external stimuli such as temperature, oxygen, chemicals, light, electric field, and mechanical force. For the systematic understanding of the underlying general mechanisms, the switching mechanisms are categorized into 4 types 1) aggregation-induced UC; 2) assembly-induced air-stable UC; 3) diffusion-controlled UC and 4) energy transfer-controlled UC. The development of stimuli-responsive smart TTA-UC systems would enable the sensing with unprecedented sensitivity and selectivity, and expand the scope of TTA-UC photochemistry by its cross-fertilization with supramolecular chemistry, materials chemistry, mechanochemistry, and biochemistry.