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Collins Navarro posted an update 6 months, 2 weeks ago
Hydrochars are materials with a promising future, as their high carbon content and porosity renders them suitable for uses including peat substitutes, soil remediation and carbon adsorbent precursors. Combining hydrothermal carbonization and pyrolysis offers the prospect to provide advanced materials with a higher porosity and carbon content. This approach would mitigate drawbacks associated to hydrochars, including phytotoxicity. This research studied the influence of pyrolysis temperature and heating time on the resulting properties of chars made from hydrothermal carbonization of biomass wastes at 200 °C for 4 h and compared them to biochars that had not received any prior hydrothermal carbonization. Interestingly, hydrochar followed by pyrolysis was able to result in phytostimulation, while, when only pyrolysis was carried out, phytotoxicity was eliminated, but no phytostimulant effect was observed. In addition, the results indicated that the higher and longer the pyrolysis temperature (from 350 to 550 °C) and duration time (from 1 to 5 h), respectively, the more microporosity was generated, while phytotoxicity was reduced. In addition, aromaticity and thermal stability significantly increased with pyrolysis treatment. Consequently, hydrochars improve their properties and offer more potential for environmental applications after a pyrolysis post-treatment. Landfills are the third largest anthropogenic source of the greenhouse gas methane worldwide. In the upper portions of landfill covers, methane is oxidized aerobically by microorganisms to form the less-potent greenhouse gas carbon dioxide; however, because of the low permeability of oxygen, no aerobic oxidation occurs in deeper portions of the cover. Therefore, the goal of this study was to enhance anaerobic oxidation of methane (AOM) in the deeper parts of landfill covers, to increase overall methane removal, via addition of electron acceptors besides oxygen. In batch tests, landfill cover soil was amended using five alternate electron acceptors iron(III), nitrate, nitrite, sulfate, and manganese. AOM was then measured via column tests, which included realistic conditions of gas flow, cover thickness, and compaction. In the batch tests, soils amended with nitrate, sulfate, and the combination of sulfate + hematite removed more methane compared to control soil. Methane generation inhibitor had no impact on net methane removal. Adding nutrients to the soil significantly enhanced methane removal only for the case of soil without electron acceptors. Greater methane removal was observed for reactors with higher initial methane concentration. Results of the column tests showed that soil amended with sulfate + iron had the highest (around 10%) removal of methane in the anoxic zone, followed by soil amended with sulfate. Hydrogen sulfide (H2S) gas was measured in the headspace of these two columns, which indicated that sulfate-reducing bacteria were likely responsible for methane removal. Obesity is a major risk factor for type 2 diabetes mellitus and insulin resistance (IR). In the state of obesity, excess fat accumulates in the liver, a key organ in systemic metabolism, altering the inflammatory and metabolic signals contributing substantially to the development of hepatic IR. Current therapies for these metabolic disorders have not been able to reverse their rapidly rising prevalence. One of the reasons is that the effects of existing drugs are predominantly non-lasting . The vagus nerve (VN) is known to play an essential role in maintaining metabolic homeostasis while decreased VN activity has been suggested to contribute to obesity associated metabolic syndrome . Several studies have reported that activation of α7 nicotinic acetylcholine receptor (α7nAChR) cholinergic signaling with or without VN intervention has protective effects against obesity-related inflammation and other metabolic complications . However, the molecular mechanisms are still not elucidated. Exaggerated endoplasmic reticulum (ER) stress and consequent dysregulated inflammation has been implicated in the development of lipid accumulation and IR . Whether targeting α7nAChR can regulate IR through these pathways is rarely reported. Accordingly, the present proposal posits that activation of the α7nAChR by VNS attenuates ER stress induced inflammation, thus ameliorating hepatic IR in Kupffer cell. We will focus on the specific interaction between vagal cholinergic activity and the modulation of ER stress induced inflammation via the α7nAChR associated pathway during IR development. Recently, the Endocrine Society has emphasized the absence of specific evidence from basic science, clinical, and epidemiological literature to assess current knowledge regarding underlying mechanisms of obesity . In this proposal, we assign a significant role to α7nAChR in obesity-induced hepatic IR, and suggest a possible therapeutic strategy with VNS intervention. Patients with anorexia nervosa (AN) present more frequently a personal history of traumatizing life events than they manifest a comorbid, clinically characterized, post-traumatic stress disorder (PTSD). The psychological impact of traumatic events on patients with AN may also manifest through a post-traumatic embitterment disorder (PTED). In PTED, the traumatic event is perceived as unjust and the patient’s response involves feelings of embitterment, rage, and helplessness along with repeated intrusive memories and a persistent negative change in mental well-being. Patients with AN share several psychopathological features with the clinical disturbed dimensions described in PTED. Accordingly, the comorbidity between PTED and AN needs further characterization. Moreover, specific therapeutic intervention known to improve symptoms of PTED such as cognitive-behavioral therapy based on wisdom psychology should be tested in selected patients with AN. Vestibular drop attacks are defined as a sudden fall to the ground without an obvious loss of consciousness lasting a few minutes or seconds. Transferase inhibitor They are usually associated with Meniere’s Disease during Tumarkin’s phase. This hypothesis was produced in consideration of the case of a young girl affected by perilymphatic fistula and her Drop attacks. Is possible to consider perilymphatic fistulas a drop attack cause? Drop attack could be related with a vestibular sympathetic reflex alteration because it is involved in blood pressure control. Probably drop attack aetiopathogenesis may be due to a sudden change in the otolith function of the utriculus and/or sacculus. At the same time flow mechanisms of cerebrospinal fluid (CSF) have a recognized impact on the origin of vestibular drop attack. According to this, the common origin of the perilymph and of the CSF may be an important argument in favour of the potential role of the fistula in the development of drop attacks.