• Jansen Frantzen posted an update 6 months, 1 week ago

    © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Extension of a fused aromatic ring core is beneficial for enhancing the intramolecular charge transfer and effective π-conjugation in A-D-A type non-fullerene acceptors (NFAs). In this work, a novel strategy involving extension of fused-ring core by symmetrically replicating core unit was developed, and a novel symmetric fused-12-ring NFA, LC81 was synthesized. When paired with the wide-bandgap polymer donor, PBT1-C, the corresponding organic solar cells (OSCs) showed a high-power conversion efficiency (PCE) of 12.71%, much higher than that of the device based on reference NFA, TPTT-4F. Moreover, the LC81-based OSC displayed a lower energy loss and a better ambient stability than the TPTT-4F-based device. Our results indicate that the extension of fused-ring core by symmetric replicating core unit is an effective strategy for promoting photovoltaic characteristics of A-D-A-type NFAs. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.The increasing demand of high-performance crystalline oxide nanomaterials for applications in current and emergent technologies is pushing research on alternative and sustainable synthesis processes, ideally complying with the principles of Green Chemistry. In this framework, wet-chemistry approaches are particularly promising, since they are typically based on soft synthesis processes, in terms of temperature and pressure, or use water and/or non-toxic alcohols as solvents. Solution methods are low-cost and simple approaches to the synthesis of nanomaterials but, to achieve sustainable, environmentally friendly and competitive manufacturing, they should address an additional target, i.e. the reduction of process energy consumption. This is one of the paradigms of Green Chemistry, where low temperatures and mild conditions of synthesis are specifically pursued. Using low temperatures for the preparation of a nanomaterial or of a nanostructured thin film does not necessarily imply sacrificing crystallinity and compositional purity of the obtained sample. Indeed, low temperatures actually afford tighter control on size and size distribution of the obtained nanostructures and of the microstructure and heterostructure of the resulting films. In this context, the present progress report provides a brief overview of low-temperature solution methods reported in the literature to attain crystalline oxide nanostructures and thin films. It intends to serve as the guiding thread for the content in this special issue dedicated to low-temperature solution approaches to oxide functional nanoscale materials . © 2020 WILEY-VCH Verlag GmbH & Co. this website KGaA, Weinheim.AIMS Ketamine is a general anesthetic. Dissociative effects and low cost led ketamine becoming an illegal recreational drug in young adults. Ketamine-induced uropathy (KIU) is one of the complications observed in abusers. This study aimed to provide a systematic literature review on KIU clinical presentation, pathophysiology, and treatments. METHODS We performed the literature search in PubMed, Web of Science, Scopus, and Embase using the terms ketamine and bladder. English papers on human and animal studies were accepted. RESULTS A total of 75 papers were selected. Regular ketamine users complain about severe storage symptoms and pelvic pain. Hydronephrosis may develop in long-term abusers and is correlated to the contracted bladder, ureteral stenosis, or vesicoureteral reflux due to ureteral involvement and/or bladder fibrosis. Cystoscopy shows ulcerative cystitis. Ketamine in urine might exert direct toxicity to the urothelium, disrupting its barrier function and enhancing cell apoptosis. The presence of ketamine/ions in the bladder wall result in neurogenic/IgE-mediated inflammation, stimulation of the inducible nitric oxide synthase-cytokines-cyclooxygenase pathway with persistent inflammation and fibrosis. Abstinence is the first therapeutic step. Anti-inflammatory drugs, analgesics and anticholinergics, intravesical instillation of hyaluronic acid, hydrodistension and intravesical injection of botulin toxin-A were helpful in patients with early-stage KIU. In patients with end-stage disease, the control of intractable symptoms and the increase of bladder capacity were the main recommendations to perform augmentation enterocystoplasty. CONCLUSIONS KIU is becoming a worldwide health concern, which should be taken into account in the differential diagnosis of ulcerative cystitis. © 2020 Wiley Periodicals, Inc.BACKGROUND This study aimed to evaluate the twist/untwist parameters of the left ventricle (LV) in patients with heart failure with preserved ejection fraction (HFpEF) measured by ultrasonic two-dimensional speckle tracking echocardiography (STE) and to examine the correlations between twist parameters and serum N-terminal pro b-type natriuretic peptide (NT-proBNP) as well as conventional two-dimensional echocardiography (2DE) indexes. HYPOTHESIS Changes in twist/untwist parameters can be used to evaluate LV function in HFpEF patients. METHODS In 63 HFpEF patients and 40 healthy controls, we analyzed LV twist/untwist parameters by STE, cardiac function by 2DE, and serum NT-proBNP by enzyme-linked immunosorbent assay (ELISA). The correlations between twist/untwist parameters and 2DE parameters and serum NT-proBNP were examined by Pearson correlation analysis. RESULTS Left ventricular end diastolic inner diameter and ejection fraction in HFpEF patients were within the normal range, whereas other 2DE parameters Wiley Periodicals, Inc.The ubiquitination and deubiquitination enzymes ensure the stability and proper function of most cellular proteins. Disturbance of either enzyme compromises tissue homeostasis. We recently have identified that the ubiquitin-specific protease 34 (USP34) contributes to bone formation by promoting osteogenic differentiation of mesenchymal stem cells. However, its role in bone resorption, which couples bone formation, remains unknown. Here we show that knockdown of Usp34 promotes osteoclast differentiation of RAW264.7 cells. Conditional knockout of Usp34 in bone marrow-derived macrophages (BMMs) or in osteoclasts leads to elevated osteoclast function and low bone mass. Mechanically, we identify that USP34 restrains NF-κB signaling by deubiquitinating and stabilizing the NF-κB inhibitor alpha (IκBα). Overexpression of IκBα represses osteoclastic hyperfunction of Usp34-deficient RAW264.7 cells. Collectively, our results show that USP34 inhibits osteoclastogenesis by regulating NF-κB signaling. © 2020 American Society for Bone and Mineral Research.

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