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Secher Trolle posted an update a month ago
The physiotherapy profession in Haiti has seen many changes since the earthquake in 2010, due to the increased number of Haitians living with permanent impairments. The earthquake sparked a significant humanitarian response. Research shows that the response focused mainly on providing short-term rehabilitation services without sustained efforts to develop sustainable rehabilitation services. A decade later, little is known about the state of the Haitian physiotherapy profession. The purpose of this study was to explore the perspectives of Haitian physiotherapy professionals regarding the current state of the profession in terms of strengths, weaknesses, opportunities and threats.
We used a qualitative exploratory descriptive design. This study consisted of two phases (1) a survey to identify potential interview participants, and identify preliminary themes to be explored in the follow-up interviews, and (2) a series of semi-structured qualitative interviews. We performed a thematic analysis of the interviy highlights the ongoing efforts of local physiotherapy associations in advocating for the profession in Haiti, which has become one of the profession’s main strengths. The lack of government funding and service planning was considered a significant barrier to overcome, as was the aftermath of the earthquake’s emergency response. Future international efforts could focus on supporting local physiotherapy associations and organisations in their endeavours to develop sustainable rehabilitation services.Epilepsy is one of the oldest known neurological disorders and is characterized by recurrent seizure activity. It has a high incidence rate, affecting a broad demographic in both developed and developing countries. Comorbid conditions are frequent in patients with epilepsy and have detrimental effects on their quality of life. Current management options for epilepsy include the use of anti-epileptic drugs, surgery, or a ketogenic diet. However, more than 30% of patients diagnosed with epilepsy exhibit drug resistance to anti-epileptic drugs. Further, surgery and ketogenic diets do little to alleviate the symptoms of patients with pharmacoresistant epilepsy. Thus, there is an urgent need to understand the underlying mechanisms of pharmacoresistant epilepsy to design newer and more effective anti-epileptic drugs. BSO inhibitor ic50 Several theories of pharmacoresistant epilepsy have been suggested over the years, the most common being the gene variant hypothesis, network hypothesis, multidrug transporter hypothesis, and target hypothesis. In our review, we discuss the main theories of pharmacoresistant epilepsy and highlight a possible interconnection between their mechanisms that could lead to the development of novel therapies for pharmacoresistant epilepsy.
To prospectively evaluate the performance of a pre-specified statistical model based on four kallikrein markers in blood (total prostate-specific antigen , free PSA, intact PSA, and human kallikrein-related peptidase 2), commercially available as the 4Kscore, in predicting Gleason Grade Group (GG) ≥2 prostate cancer at biopsy in an international multicentre study at three academic medical centres, and whether microseminoprotein-β (MSP) adds predictive value.
A total of 984 men were prospectively enrolled at three academic centres. The primary outcome was GG ≥2 on prostate biopsy. Three pre-specified statistical models were used a base model including PSA, age, digital rectal examination and prior negative biopsy; a model that added free PSA to the base model; and the 4Kscore.
A total of 947 men were included in the final analysis and 273 (29%) had GG ≥2 on prostate biopsy. The base model area under the receiver operating characteristic curve of 0.775 increased to 0.802 with the addition of free PSA, and to 0.824 for the 4Kscore. Adding MSP to the 4Kscore model yielded an increase (0.014-0.019) in discrimination. In decision-curve analysis of clinical utility, the 4Kscore showed a benefit starting at a 7.5% threshold.
A prospective multicentre evaluation of a pre-specified model based on four kallikrein markers (4Kscore) with the addition of MSP improves the predictive discrimination for GG ≥2 prostate cancer on biopsy and could be used to inform biopsy decision-making.
A prospective multicentre evaluation of a pre-specified model based on four kallikrein markers (4Kscore) with the addition of MSP improves the predictive discrimination for GG ≥2 prostate cancer on biopsy and could be used to inform biopsy decision-making.
Physiological race determination of 143 Fusarium oxysporum f. sp. lycopersici (FOL) isolates collected along 30years in major tomato-producing regions of Brazil.
Physiological races were determined via root-dipping inoculation of differential tomato accessions and by the PCR-based marker system of Hirano and Arie (2006). According to pathogenicity/virulence assays, five race 1, 23 race 2 and 115 race 3 isolates were identified. FOL race 1 and 2 isolates prevailed up to early 2000s. Afterwards, the large majority of the isolates was classified as the invasive race 3. Novel reports of race 3 were done in five states, thus expanding its geographical distribution. Using this PCR-based marker system, a precise discrimination was observed for all race 3 isolates. However, all race 1 and 2 isolates displayed only the cosmopolitan race 1-specific amplicon pattern.
The development and/or validation of novel race-specific marker systems are necessary to allow a precise discrimination of the potentially endemic Brazilian FOL race 2.
The present characterization of isolates indicates that distinct evolutionary mechanisms are acting to select new FOL races and/or genetic variants across agroecosystems around the globe.
The present characterization of isolates indicates that distinct evolutionary mechanisms are acting to select new FOL races and/or genetic variants across agroecosystems around the globe.
Data on sex differences in acromegaly at the time of diagnosis vary considerably between studies.
A nationwide cohort study including all incident cases of acromegaly (1978-2010, n=596) and a meta-analysis on sex differences in active acromegaly (40 studies) were performed.
Sex-dependent differences in prevalence, age at diagnosis, diagnostic delay, pituitary adenoma size, insulin-like growth factor 1 (IGF-I) and growth hormone (GH) concentrations were estimated.
The cohort study identified a balanced gender distribution (49.6% females) and a comparable age (years) at diagnosis (48.2 CI95% 46.5-49.8 (males) vs. 47.2 CI95% 45.5-48.9 (females), p=0.4). The incidence rate significantly increased during the study period (R
=0.42, p<0.01) and the gender ratio (F/M) changed from female predominance to an even ratio (SR 1.4 vs. 0.9, p=0.03). IGF-I
was significantly lower in females compared to males, whereas neither nadir GH nor pituitary adenoma size differed between males and females. In the meta-analysis, the weighted percentage female was 53.