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Egan Purcell posted an update a month ago
The difference between the genders’ suicide rate changed significantly at the onset of recession, as the rate for men increased and the rate for women decreased.
The Danish social welfare model might have prevented social disintegration and suicide among unemployed, and suicide prevention programmes might have prevented deaths among unemployed and mentally ill individuals.
We found some indications for gender-specific differences from the impact of the financial crises on the suicide rate. We recommend that men should be specifically targeted for appropriate prevention programmes during periods of economic downturn.
We found some indications for gender-specific differences from the impact of the financial crises on the suicide rate. We recommend that men should be specifically targeted for appropriate prevention programmes during periods of economic downturn.
ABP 501 is a biosimilar to the anti-tumor necrosis factor-alfa monoclonal antibody adalimumab and despite its effectiveness and safety in the treatment of psoriasis was demonstrated in randomized clinical trials, no real-life data are available, in particular in patients undergoing non-medical switch from originator to biosimilar.
We retrospectively searched our clinical records for all patients receiving ABP 501 between March 10, 2019 and September 7, 2019 at our Department. Therefore, we identified 94 patients, 46 patients underwent non-medical switch from adalimumab reference product to ABP 501.
In originator-naïve patients, mean PASI significantly improved from baseline to week 24 (
< .0001) in both Pso and PsA cohorts. In these patients, mean DAS-28 ESR improved with no significant differences from baseline. In patients undergoing non-medical switch from adalimumab reference product to ABP 501, no significant difference in PASI or DAS-28 ESR were observed from week 16 before switch to week 24 after switch.
AB- 501 is an effective treatment for plaque-type psoriasis and psoriatic arthritis regardless if patients are originator-naïve or if they were switched from the reference product.
AB- 501 is an effective treatment for plaque-type psoriasis and psoriatic arthritis regardless if patients are originator-naïve or if they were switched from the reference product.
Lung cancer is an important complication of combined pulmonary fibrosis and emphysema (CPFE). Whether the risk of lung cancer is higher in CPFE patients with usual interstitial pneumonia (UIP) than those with idiopathic pulmonary fibrosis (IPF) alone, remains controversial. Belnacasan We conducted this systematic review and meta-analysis to evaluate the prevalence of lung cancer in CPFE patients with UIP compared with IPF patients.
We searched the PubMed, Embase, and Cochrane databases for studies that focused on the incidence of lung cancer in CPFE/UIP and IPF groups. We used a fixed-effects model to analyze the odds ratios (ORs) with 95% confidence intervals (CIs) according to data heterogeneity. The cumulative effects based on the publication year and sample size were assessed by cumulative meta-analysis.
A total of nine studies with 933 patients, including 374 CPFE patients with UIP, fulfilled the inclusion criteria. Overall, CPFE patients with UIP have a higher risk of lung cancer than those with IPF alone (OR = 2.69; 95% CI 1.78-4.05). There were increased risks of lung cancer in CPFE/UIP patients with the presence of emphysema (OR = 2.93; 95% CI 1.79-4.79) or emphysema in ⩾10% of the lung volume (OR = 2.22; 95% CI 1.06-4.68).
Our systematic review and meta-analysis indicated a significantly higher prevalence of lung cancer in CPFE patients with UIP than in patients with IPF alone.
Our systematic review and meta-analysis indicated a significantly higher prevalence of lung cancer in CPFE patients with UIP than in patients with IPF alone.The reviews of this paper are available via the supplemental material section.Death, grief, and loss have always been a part of the military community. Historically, research on grief in the military has focused on the impact of combat operations and deployment separations on the grief experience of service members and loved ones. However, as the transient nature of military life and the dangers of military service exist outside of combat operations and military deployments, it is important to examine how grief may impact the military community in times of peace as well as war. The purpose of this commentary is to discuss the components of the military community that place its members at a higher risk of experiencing complicated grief.
One approach to measure the demographic impacts of death is to examine the number of lost years of life. The present paper aims to estimate the “Years of Lost Life” (YLL) due to the main causes of death in Yazd province of Iran.
The present study is an epidemiological examination for which the statistical population included all the death incidents in Yazd province (excluding stillbirth cases) over two time periods of 2011 and 2016 with a 5-year distance. The required data were obtained based on the Comprehensive System of Mortality Registration maintained by the Ministry of Health and Medical Education; while the standard life expectancy data were based on the World Health Organization standards using standard life table, level 26 of the West model (Coale and Demeny) for Japanese men and women. The standard YLL was calculated according to the WHO standard using a 0.03 relaxation rate for the future time and weighting coefficient for various ages and life years through the formula using the Microsoft Excel software.
The findings of the present study suggest that two main causes of YLL in Yazd province during the year of 2011 were cardiovascular difficulties with the rates of 31.6 per 1000 persons for women and 27.1 per 1000 persons for men, and cancers with the rates of 14.9 per 1000 persons for women and 16.2 per 1000 persons for men. While the above numbers in 2016 were, respectively 22.5 per 1000 persons for women and 25.5 per 1000 persons for men due to cardiovascular difficulties; and 18 per 1000 persons for women and 15.5/1000 for men due to various types of cancers.
Our findings suggest that cardiovascular diseases and cancers are the main factors leading to Years of Lost Lifetime for the residents of Yazd province in Iran.
Our findings suggest that cardiovascular diseases and cancers are the main factors leading to Years of Lost Lifetime for the residents of Yazd province in Iran.