• Hyldgaard Ulrich posted an update 6 months, 1 week ago

    In this review, we discuss how chemokine receptors and their ligands regulate the trafficking and localization of NK cells in hematological tumors and how the chemokine function can be manipulated to improve current therapeutic approaches.Beginning in the late-1800s, gold mining activities throughout Nova Scotia, eastern Canada, released contaminants, notably geogenic arsenic from milled ore and anthropogenic mercury from amalgamation, to local environments via surface water flows through tailings fields. We investigated recovery from and legacy effects of the tailings field at the Montague Gold District (~1863-1940) on nearby urban lake ecosystems using geochemical measures and zooplankton remains archived in dated sediment cores from an impact (Lake Charles) and a reference (Loon Lake) lake. Sedimentary levels of total arsenic and total mercury were used to assess mining-related inputs. Arsenic concentrations remain elevated at nearly 300 times above sediment guidelines in Lake Charles surface sediments, due to its upward mobilization from enriched sediment intervals and sequestration by iron oxyhydroxides in surficial sediments. Peak mercury concentrations at Lake Charles were eight times above sediment guidelines during the mining period, and since ~1990 have recovered to levels observed before mining began. Legacy mining impacts at Lake Charles and non-mining related environmental changes in the post-1950 sediments at both lakes have thus combined to structure assemblage compositions of primary consumers. At both lakes, assemblages of pelagic-dominated Cladocera differed (p ≤ 0.05) during the mining period compared to periods before and after mining. Taxon richness differed (p ≤ 0.01) only between the pre- and post-mining periods at mining-impacted Lake Charles and reflects long-term declines of substrate-dwelling littoral taxa. Geochemical and biological recovery have not completely occurred at Lake Charles despite the mine district’s closure ~80 years ago. Our findings demonstrate that impacts of ore processing and amalgamation from historical gold mining, combined with recent watershed stressors, continue to affect sedimentary arsenic geochemistry and intermediate trophic levels of nearby, downstream aquatic habitats.Melioidosis is an endemic disease in Southeast Asia and Oceania caused by the gram-negative bacillus Burkholderia pseudomallei. We studied 15 adult patients from Colombia with microbiologically diagnosed pulmonary melioidosis. We reviewed 15 chest X-rays and 10 chest computed tomography (CT) studies. Of the 15 patients, 87% met the criteria for acute infection and 13% met the criteria for chronic infection. The most common findings on chest X-rays were consolidation (86%), nodules (26%), and cavitation (20%). On CT studies, consolidation and nodules were observed in 90% of cases; the areas of consolidation were predominantly located in the basal and central zones in 60%. selleck chemical Areas of cavitation were observed in 50%, pleural effusion in 60%, and mediastinal lymph nodes in 30%. In patients with acute pulmonary melioidosis (n=8), the findings observed were nodules (100%), mixed pattern with nodules and consolidation (87%), pleural effusion (88%), and mediastinal lymph nodes (25%). The two patients with chronic pulmonary melioidosis both had cavitation. Acute lung infection with B. Pseudomallei has radiologic manifestations similar to those of pneumonia due to other causes. In areas where the disease is endemic, it is essential to include acute melioidosis in the differential diagnosis of pulmonary nodules and chronic melioidosis in the differential diagnosis of cavitated chronic lung lesions.More than 30 years have passed since Mehler et al. (1988) proposed that newborns can discriminate between languages that belong to different rhythm classes stress-, syllable- or mora-timed. Thereupon they developed the hypothesis that infants are sensitive to differences in vowel and consonant interval durations as acoustic correlates of rhythm classes. It remains unknown exactly which durational computations infants use when perceiving speech for the purposes of distinguishing languages. Here, a meta-analysis of studies on infants’ language discrimination skills over the first year of life was conducted, aiming to quantify how language discrimination skills change with age and are modulated by rhythm classes or durational metrics. A systematic literature search identified 42 studies that tested infants’ (birth to 12 months) discrimination or preference of two language varieties, by presenting infants with auditory or audio-visual continuous speech. Quantitative data synthesis was conducted using multivariateonalise rhythm in language in the extent to which it accounts for infants’ language discrimination abilities.

    Targeting the modifiable risk factors for coronary artery disease (CAD) has substantial impact at the community level. However, it is not uncommon for individuals to present with atherosclerosis related events without identified risk factors. We examined sex differences in the association of risk factors and atherosclerotic burden assessed by CT coronary angiography (CTCA).

    We analysed clinical and imaging data in 1002 individuals in the BioHEART cohort.

    45% were female, 35% had no CAD identified. Median coronary calcium score was 9.9 Agatston units (IQR 0-146), and median Gensini Score was 3.5 (IQR 0-11.5). 26% had a calcified plaque predominant phenotype, and 18% had a non-calcified plaque predominant phenotype. There were no sex differences in the prevalence of risk factors. However, there were notable sex differences in the adjusted associations of risk factors with CAD. Age and hypercholesterolaemia (OR 1.56, 95% CI 1.03-2.36, p=0.04 in males, and OR 1.75, 95% CI 1.09-2.78, p =0.02 in females) were associated with the presence of CAD in both genders (p<0.05). Diabetes and smoking were associated with presence of CAD, calcified CAD, and non-calcified plaque in males (p <0.05) but not females. In women, none of the standard modifiable risk factors were associated with the amount of plaque present when adjusted for age, BMI, and family history of premature CAD.

    CTCA provides an important opportunity for improving the stratification of cohorts to assess underlying biology and risk. We demonstrate sex-specific differences in associations of risk factors with atherosclerosis burden.

    CTCA provides an important opportunity for improving the stratification of cohorts to assess underlying biology and risk. We demonstrate sex-specific differences in associations of risk factors with atherosclerosis burden.

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