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Erichsen McIntosh posted an update 6 months, 3 weeks ago
This information may be utilized by the healthcare professionals for screening and identifying potential DDIs with adverse outcomes, based on their severity and documentation levels and consequently design prophylactic and management strategies for their prevention. Identification, reporting and management of DDIs and dissemination of related information should be a major consideration in the delivery of lung cancer care during this ongoing COVID-19 pandemic for better patient outcomes and updating guidelines for safer prescribing practices in this coinfected condition.Endogenous pollution from sediments is gradually becoming a critical pollution source of the drinking water reservoir. Odorants can be released from sediments into the overlying water which further deteriorate the water quality of the drinking water reservoir. In this work, we set the sediment-overlying water systems under various water pH (6.5, 8 and 9), temperature (4, 20 and 30 °C) during 30 days and intermittent or continuous hydraulic disturbances (at 100 r/min or 200 r/min) in 5 days, and investigated the dynamic release of odorants from the drinking water reservoir sediments via using headspace solid-phase microextraction (HSPME) and gas chromatography-mass spectrometry (GC-MS). The result shows that weakly alkaline environment slightly but not significantly increased the concentration of dimethyl disulfide (DMDS) in the overlying water. Furthermore, low temperature promoted the release of bis(2-chloroisopropyl) ether (BCIE) and geosmin to 108.36 and 18.98 ng/L, respectively, while high temperature facilitated the DMDS release to 20.33 ng/L. Notably, hydraulic disturbances drastically elevated the level of seven odorants released from the sediments. Specially, benzaldehyde exhibited highest concentration at 260.50 ng/L. The continuous disturbance greatly enhanced the release of benzaldehyde, DMDS, dimethyl trisulfide (DMTS), BCIE and 1,4-dichloro-benzene (1,4-DCB) from sediments with a positive disturbance speed-dependence. However, the intermittent disturbance promoted higher level of geosmin in the overlying water compared to the continuous disturbance. selleck chemicals Only continuous hydraulic disturbance at high speed could lead to the release of ethylbenzene from sediments, which was up to 4.89 ng/L in 12 h.
Thallium is a widely known toxic heavy metal that has been reported have embryo toxicity.
We aimed to investigate the relationship of prenatal thallium exposure with neonatal telomere length.
A total of 746 mother-newborn pairs were recruited from Wuhan Children Hospital between November 2013 and March 2015 in Wuhan City, China. Maternal thallium exposure levels were measured in spot urine samples collected during the three trimesters and during hospital delivery using inductively coupled plasma mass spectrometry. Neonatal relative telomere length (rTL) was measured by a real-time quantitative polymerase chain reaction assay in cord blood. Multiple informant models were used to evaluate the association of maternal thallium exposure with neonatal rTL.
After adjustment for multiple potential confounders, each 25% incremental increase of maternal thallium exposure, measured in urine samples collected during hospital delivery, was associated with a 1.85% shortened neonatal rTL (95% CI-3.62%,-0.05%; P=0.044). Similarly, mothers in the highest quartile of urinary thallium exposure had a 11.74% (95% CI-21.57%,-0.68%; P=0.038) shorter cord blood leukocyte rTL than those in the lowest quartile. However, no significant association was found between neonatal rTL and maternal thallium exposure measured in urine samples collected during the three trimesters of pregnancy.
This study reveals that prenatal thallium exposure was related to shortened neonatal telomere length in Chinese population, pointing to the important role of thallium exposure in accelerating biological aging.
This study reveals that prenatal thallium exposure was related to shortened neonatal telomere length in Chinese population, pointing to the important role of thallium exposure in accelerating biological aging.Phenanthrene contaminated soil was remediated by the photochemical process of ferrous oxalate. Without using H2O2 and adjusting soil pH, phenanthrene in contaminated soil was degraded effectively by the ferrous oxalate under visible light irradiation. Ferrous oxalate possesses excellent visible light absorption ability which benefits the degradation of phenanthrene in soil under visible light irradiation. Via the Fe(II)/Fe(III) catalytic cycle of ferrous oxalate, H2O2 and Fe(II) could be produced continuously and H2O2 was further catalyzed by Fe(II) and released hydroxyl radicals (•OH) to degrade the phenanthrene in soil. The dosage of ferrous oxalate, moisture content of soil, and soil thickness were most important factors for degradation of phenanthrene in soil. In addition, a good mixing of ferrous oxalate and soil was vital for enhancing the degradation ratio of phenanthrene. After phenanthrene contaminated soil was treated by ferrous oxalate, the toxicity of treated soil was evaluated via the lettuce cultivation experiments. It was demonstrated the toxicity of phenanthrene contaminated soil was significantly reduced by ferrous oxalate according to the growth indexes of lettuces, including root length, leaf length, and fresh weight. This environment-friendly soil remediation method based on ferrous oxalate has huge potential in the remediation of organic pollutant contaminated soil.
This study investigates the effects of water-extracted PM
on a triple-negative breast cancer (TNBC) cell line, MDA-MB-231, by sampling suspended particulates around a building demolition site.
PM
particles were obtained using a high-flow TISCH sampler. Water-soluble PM
were extracted by an ultrasonic oscillator and then freeze-dried. The heavy metal components of soluble PM
was analyzed by ICP-MS. Cell viability was evaluated by MTT assay for cells that were exposed to PM
(200, 400 and 600μg/mL). Wound healing and transwell cell migration and invasion assays were used to measure cell motility and the invasiveness of cancer cells that had been exposed to PM
into a chemo-attractant substance. Interrelated mechanisms of cancer malignancy were analyzed by Western blot analysis.
Nearby PM
concentrations increased significantly during the deconstruction of buildings, and the Cd, Cu, Pb, Zn and Cr contents of soluble PM
also significantly increased. Following exposure to PM
, the survival rate of breast cancer cells was significantly higher than that of the control group.