• Tillman Doherty posted an update 6 months, 4 weeks ago

    Purposes During the outbreak of Coronavirus Disease 2019 (COVID-19) all over the world, the mental health conditions of health care workers are of great importance to ensure the efficiency of rescue operations. The current study examined the effect of social support on mental health of health care workers and its underlying mechanisms regarding the mediating role of resilience and moderating role of age during the epidemic. Methods Social Support Rating Scale (SSRS), Connor-Davidson Resilience scale (CD-RISC) and Symptom Checklist 90 (SCL-90) were administrated among 1472 health care workers from Jiangsu Province, China during the peak period of COVID-19 outbreak. Structural equation modeling (SEM) was used to examine the mediation effect of resilience on the relation between social support and mental health, whereas moderated mediation analysis was performed by Hayes PROCESS macro. Results The findings showed that resilience could partially mediate the effect of social support on mental health among health care workers. Age group moderated the indirect relationship between social support and mental health via resilience. Specifically, compared with younger health care workers, the association between resilience and mental health would be attenuated in the middle-aged workers. Conclusions The results add knowledge to previous literature by uncovering the underlying mechanisms between social support and mental health. The present study has profound implications for mental health services for health care workers during the peak period of COVID-19.Alpha-toxin (Hla) is a major virulence factor of Staphylococcus aureus (S. aureus) and plays an important role in S. aureus-induced pneumonia. It binds as a monomer to the cell surface of eukaryotic host cells and forms heptameric transmembrane pores. Sensitivities toward the toxin of various types of potential host cells have been shown to vary substantially, and the reasons for these differences are unclear. We used three human model airway epithelial cell lines (16HBE14o-, S9, A549) to correlate cell sensitivity (measured as rate of paracellular gap formation in the cell layers) with Hla monomer binding, presence of the potential Hla receptors ADAM10 or α5β1 integrin, presence of the toxin-stabilizing factor caveolin-1 as well as plasma membrane lipid composition (phosphatidylserine/choline, sphingomyelin). The abundance of ADAM10 correlated best with gap formation or cell sensitivities, respectively, when the three cell types were compared. Caveolin-1 or α5β1 integrin did not correlate with toxin sensitivity. The relative abundance of sphingomyelin in plasma membranes may also be used as a proxi for cellular sensitivity against alpha-toxin as sphingomyelin abundances correlated well with the intensities of alpha-toxin mediated gap formation in the cell layers.We investigated the effects of long-term exposure to literary and popular fiction on attributional complexity, egocentric bias and accuracy. Results of a pre-registered study showed that exposure to literary fiction is positively associated with scores on the attributional complexity scale. Literary fiction is also associated with accuracy in mentalizing, measured via the Reading the Mind in the Eyes test, and with accuracy in predicting average social attitudes. The predicted negative association between literary fiction and egocentric bias emerged only when education and gender were controlled for-a covariance analysis that was not pre-registered. Exposure to popular fiction is associated solely with attributional complexity, but negatively. Bindarit clinical trial We discuss the significance of these findings in the context of the emerging literature regarding the relationship between fiction and social cognition.Background Mother to child transmission (MTCT) of HIV remains a challenge in resource-limited settings. Central to elimination of MTCT is effective Provider Initiated HIV Counseling and Testing (PICT). Research has shown that conducting PICT only at the initial antenatal care (ANC) visit fails to benefit pregnant women who seroconvert later in their pregnancy. This study aimed to determine the most cost effective time to perform repeat HIV testing during ANC and perinatal care (PNC). Methods We studied the repeat HIV testing results of pregnant women ≥ 18 and adolescent girls aged 15-17 in the Sauri, Kenya Millennium Villages Project (MVP) site. Nurses provided HIV screening to 1,403 expectant women and 256 adolescent girls following the 1st, 2nd, 3rd and 4th ANC visits, at birth and 6 and 14 weeks postpartum. Results Five women seroconverted during the study period (incidence proportion 0.41%). One woman seroconverted at the 2nd ANC visit, another one at the 3rd, two at the 4th and one at 6 weeks post-partum. Of all the women who seroconverted, four reported an HIV negative primary partner, while one reported an unknown partner status. None of the participants reported condom use during pregnancy. Two of the seroconverters vertically transmitted HIV to their babies. The results did not suggest a clear pattern of seroconversion during ANC and PNC. Conclusions The low rates of seroconversion suggest that testing pregnant women multiple times during ANC and PNC may not be cost effective, but a follow-up test during birth may be protective of the newborn.Naturally growing vegetation often suffers from the effects of drought. There exists a vast number of drought indices (DI’s) to assess the impact of drought on the growth of crops and naturally occurring vegetation. However, assessing the fitness of these indices for large areas with variable vegetation cover is often problematic because of the absence of adequate spatial information. In this study, we compared six DI’s to NDVI (the normalized difference vegetation index), a common indicator of vegetation occurrence and health based on satellite-acquired reflectance data. The study area covers an aridity gradient from forests to deserts along a 2,400-km-long section across the Inner Mongolia Autonomous Region of China. On an annual timescale, standardized precipitation index (SPI) was the most appropriate in assessing drought in steppes and deserts. On a seasonal timescale, the self-calibrated Palmer drought severity index (scPDSI) displayed the greatest sensitivity during the summer, but not during the other seasons.

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