• Welch Stephens posted an update 7 months ago

    017) than patients without LUTS. They also scored more poorly on muscle function tests. Urodynamic results point to neurogenic causes for LUTS in LOPD, that is, neurogenic reflex bladder or impaired filling sensation. This could be due to glycogen accumulation in the urothelium and central nervous system. Patients with LUTS also seem to be more severely affected by LOPD than patients without LUTS. CONCLUSION LUTS in LOPD requires early and specific treatment to limit the development of severe health problems. Urodynamic studies should be considered in assessing LUTS. © 2020 The Authors. Neurourology and Urodynamics published by Wiley Periodicals, Inc.OBJECTIVES Intrathecal drug delivery systems (IDDS) are an important method of pain control for patients with refractory oncologic pain. Local anesthetics such as bupivacaine have been infused either alone or with opioids. While effective, bupivacaine can cause adverse effects such as numbness, weakness, and urinary retention. This study looks to establish a safe and efficacious fixed bupivacaine dosing algorithm in intrathecal pumps for cancer patients. MATERIALS AND METHODS A bupivacaine dosing algorithm was developed using data from 120 previous patients who underwent IDDS placement at Memorial Sloan Kettering Cancer Center. The outcomes were then evaluated for 43 subsequent patients who were treated with bupivacaine IDDS according to our aforementioned algorithm. RESULTS Our data show that in patients treated with our bupivacaine guideline, visual analog pain scale scores decreased by 59% and oral morphine equivalence decreased by 70% from the period between IDDS implantation until discharge from the MSKCC hospital. However, 16.3% of our patients had bupivacaine-related side effects. CONCLUSIONS For oncological patients, our data and experience support the initiation of intrathecal bupivacaine at the following doses 5 mg/day for catheter tips in the cervical spine, 8 mg/day for catheter tips at T1-4, and 10 mg/day for catheter tips at T5-8. Given the higher likelihood of adverse effects in catheters at T9-12 and the lumbar spine, we start at 8 mg/day with close follow-up of the patient. Initiating these doses allow our patients to safely reach adequate analgesia faster, with a shorter hospitalization and quicker return to anti-cancer therapy. © 2020 International Neuromodulation Society.BACKGROUND The rice bacterial leaf blight (BLB) is one of the most serious bacterial diseases caused by Xanthomonas oryzae pv. oryzae (Xoo), which can cause yield loss of the rice up to 50%. The three-dimensional quantitative structure-activity relationship (3D-QSAR) is an important auxiliary method to find potential high-efficient pesticides active structures. RESULTS A series of novel 1,3,4-oxadiazole compounds were designed and synthesized based on the 3D-QSAR model, and their antibacterial activities in vitro against Xoo were evaluated. The results indicated that all the target compounds showed excellent in vitro antibacterial activities. For example, the compounds 6, 12, 13, 20, 21, and 23 exhibited excellent antibacterial activities against Xoo, with the EC50 values of 0.24, 0.31, 0.36, 0.29, 0.19, 0.31 mg/L, respectively, which were superior to the antibacterial agents thiodiazole copper (127.44 mg/L) and bismerthiazol (91.08 mg/L). Meanwhile, the compound 21 showed good antibacterial activity in vivo against BLB, with curative and protective activities of 46.7% and 56.4%, respectively, which were superior to the thiodiazole copper (28.5% and 32.5%) and bismerthiazol (37.6% and 38.4%). The compound 21 can significantly reduce the extracellular polysaccharides production of the Xoo, increase the permeability of the cell membranes, and also can cause the cell surface wrinkles, deformation and dryness. CONCLUSION The 3D-QSAR model can be used to find sulfone compounds containing a 1,3,4-oxadiazole moieties with higher antibacterial activity, and the compound 21 can be used as a potential antibacterial agent in the future. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Marine dinoflagellates produce remarkable organic molecules, particularly those with polyoxygenated long carbon-chain backbones, namely super-carbon-chain compounds (SCCCs), characterized by the presence of numerous stereogenic carbon centers on acyclic polyol carbon chains. Even today, it is of a great challenge to determine the absolute configurations of these compounds. In this work, the planar structures and absolute configurations of two highly flexible SCCCs, featuring a C 69 – or C 71 -linear carbon backbone, named gibbosols A and B, respectively, each containing thirty-seven stereogenic carbon centers, were unambiguously established by a combined chemical, spectroscopic, and computational approach. The discovery of gibbosols A and B with two hydrophilic acyclic polyol chains, represents an unprecedented class of SCCCs. Nafamostat A reasonable convergent strategy for the biosynthesis of these SCCCs was proposed. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.The chemical ligation of two unprotected peptides to generate a natural peptidic linkage specifically at the C – and N -termini is a challenging but desirable platform for protein chemical synthesis, as it demands high reactivity and selectivities (chemo-, regio- and stereoselectivity). Here, we report an operationally simple and highly effective chemical peptide ligation involving peptides with C -terminal salicylaldehyde esters to ligate peptides with N -terminal cyste-ine/penicillamine. The notable features of this method include its tolerance of steric hinderance from the side groups on either ligating terminus, allowing the flexible disconnection at sites that are otherwise difficult to functionalize. In addition, this method can be expanded to selective desulfurization and one-pot ligation-desulfurization reactions. The effectiveness of this method was demonstrated by synthesis of VISTA (216-311), PD-1 (192-288) and Eglin C. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.INTRODUCTION To determine whether individuals with a history of anterior cruciate ligament reconstruction (ALCR) exhibit altered neuromotor function compared to healthy controls. It was hypothesized that the ACLR group would have slower postural responses compared to healthy individuals of similar age. MATERIALS AND METHODS Sixteen adults with a unilateral ACLR and 16 matched healthy controls participated. General assessments of neuromotor function were gathered and included measures of reaction time (both seated and postural conditions), walking ability, balance, ankle ROM, proprioception, knee joint laxity, patellar tendon reflex latency, and quadriceps strength. Data were analyzed using mixed generalized linear models with between-subject (i.e., controls, ACLR) and within-subject factors (i.e., affected, unaffected limb). RESULTS Individuals with an ACLR exhibited a significant slowing of their postural reaction times compared to the control individuals. The ACLR group was slower under both the simple (ACLR 484±6.

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